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Mitochondrial ribosomal protein L41

PIG3, mitochondrial ribosomal protein L41, TP53I3
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the YmL27 ribosomal protein family. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: p53, p21, Bax, CAN, mdm2
Papers on PIG3
Reactivation of p53 by a Cytoskeletal Sensor to Control the Balance Between DNA Damage and Tumor Dissemination.
Sanz-Moreno et al., Murcia, Spain. In J Natl Cancer Inst, Jan 2016
This results in a specific transcriptional signature enriched in DNA damage/oxidative stress responsive genes, including Tumor Protein p53 Inducible Protein 3 (TP53I3 or PIG3).
Critical role of ARID3B in the expression of pro-apoptotic p53-target genes and apoptosis.
Ikeda et al., Tokyo, Japan. In Biochem Biophys Res Commun, Jan 2016
ARID3B and, to a lesser extent, ARID3A silencing blocked transcriptional activation of pro-apoptotic p53 target genes, such as PUMA, PIG3, and p53.
PIG3 plays an oncogenic role in papillary thyroid cancer by activating the PI3K/AKT/PTEN pathway.
Liang et al., Wenzhou, China. In Oncol Rep, Sep 2015
The p53-inducible gene 3 (PIG3 or TP53I3) is a downstream gene of p53, which can be involved in the process of apoptosis induced by p53 via the production of reactive oxygen species (ROS).
The Critical Role of Rab31 in Cell Proliferation and Apoptosis in Cancer Progression.
Yan et al., Jinan, China. In Mol Neurobiol, Sep 2015
Meanwhile, Rab31 inhibits U87 and SiHa cell apoptosis, and decreased the BAX and PIG3 expression, but enhanced BCL2 expression.
The p53-inducible gene 3 involved in flavonoid-induced cytotoxicity through the reactive oxygen species-mediated mitochondrial apoptotic pathway in human hepatoma cells.
Liu et al., Jiamusi, China. In Food Funct, May 2015
Here we investigated the potential mechanism that p53-inducible gene 3 (PIG3), a NADPH:quinone oxidoreductase, mediated the prooxidant cytotoxicity of flavonoids on human hepatoma HepG2 cells.
BRCA1 regulates PIG3-mediated apoptosis in a p53-dependent manner.
Guan et al., Nanjing, China. In Oncotarget, May 2015
Meanwhile, the p53 inducible gene 3 (PIG3) is a downstream target of p53 and is involved in p53-initiated apoptosis.
Toxic effects of cadmium on flatworm stem cell dynamics: A transcriptomic and ultrastructural elucidation of underlying mechanisms.
Smeets et al., Diepenbeek, Belgium. In Environ Toxicol, May 2015
These results were supported by gene expression data: transcripts of cdc2 and pig3 were significantly upregulated during all treatments.
HPIP is upregulated in colorectal cancer and regulates colorectal cancer cell proliferation, apoptosis and invasion.
Ye et al., Beijing, China. In Sci Rep, 2014
HPIP inhibits CRC cell apoptosis accompanied by the decreased levels of BAX and PIG3, the inducers of apoptosis, and the increased level of the apoptosis inhibitor BCL2.
PIG3: a novel link between oxidative stress and DNA damage response in cancer.
Gorgoulis et al., Athens, Greece. In Cancer Lett, 2013
P53 inducible gene 3 (PIG3 or TP53I3) was identified in an analysis of genes induced by p53 before the onset of apoptosis.
p53-induced gene 3 mediates cell death induced by glutathione peroxidase 3.
Yu et al., Pittsburgh, United States. In J Biol Chem, 2012
a novel signaling pathway of GPx3-PIG3 in the regulation of cell death in prostate cancer.
Deletion mutational analysis of BMRP, a pro-apoptotic protein that binds to Bcl-2.
González-García et al., Kingsville, United States. In Mol Cell Biochem, 2011
region of BMRP required for the interaction with Bcl-2 is very relevant for the cell death-inducing activity of the protein
Resveratrol and apoptosis.
Davis et al., Albany, United States. In Ann N Y Acad Sci, 2011
Chromatin immunoprecipitation reveals binding of nuclear COX-2 to promoters of certain p53-responsive genes, including PIG3 and Bax.
Why is p53-inducible gene 3 rarely affected in cancer?
Gorgoulis et al., In Oncogene, 2010
certain p53 mutatants activate PIG3, whereas the result of our study show increased full-length transcript expression in tumor counterparts
The p53-inducible gene 3 (PIG3) contributes to early cellular response to DNA damage.
You et al., Kwangju, South Korea. In Oncogene, 2010
Results suggest that PIG3 is a critical component of the DNA damage response pathway and has a direct role in the transmission of the DNA damage signal from damaged DNA to the intra-S and G2/M checkpoint machinery.
Three-dimensional structure and enzymatic function of proapoptotic human p53-inducible quinone oxidoreductase PIG3.
Parés et al., Barcelona, Spain. In J Biol Chem, 2009
PIG3 action is through oxidative stress produced by its enzymatic activity and provides essential knowledge for eventual control of apoptosis.
hCAS/CSE1L associates with chromatin and regulates expression of select p53 target genes.
Prives et al., New York City, United States. In Cell, 2007
We report here that the human cellular apoptosis susceptibility protein (hCAS/CSE1L) associates with a subset of p53 target promoters, including PIG3, in a p53-autonomous manner.
A novel human p53 isoform is an essential element of the ATR-intra-S phase checkpoint.
Dornreiter et al., Hamburg, Germany. In Cell, 2005
In contrast to p53, Deltap53 transactivates the endogenous p21 and 14-3-3sigma but not the mdm2, bax, and PIG3 promoter.
Myc suppression of the p21(Cip1) Cdk inhibitor influences the outcome of the p53 response to DNA damage.
Massagué et al., New York City, United States. In Nature, 2002
The cytostatic effect of p53 is mediated by transcriptional activation of the cyclin-dependent kinase (CDK) inhibitor p21(Cip1), whereas the apoptotic effect is mediated by transcriptional activation of mediators including PUMA and PIG3 (ref.
A polymorphic microsatellite that mediates induction of PIG3 by p53.
Dobbelstein et al., Marburg an der Lahn, Germany. In Nat Genet, 2002
The gene PIG3 is induced by the tumor suppressor p53 but not by p53 mutants unable to induce apoptosis, suggesting its involvement in p53-mediated cell death.
Regulation of p53 downstream genes.
el-Deiry, Philadelphia, United States. In Semin Cancer Biol, 1997
The wide range of p53's biological effects can in part be explained by its activation of expression of a number of target genes including p21WAFI, GADD45, 14-3-3 sigma, bax, Fas/APO1, KILLER/DR5, PIG3, Tsp1, IGF-BP3 and others.
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