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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Tumor protein p53 inducible nuclear protein 2

PIG-U, TP53INP2
Top mentioned proteins: GAA1, LC3, p53, Sip, OUT
Papers on PIG-U
The combined use of miRNAs and mRNAs as biomarkers for the diagnosis of papillary thyroid carcinoma.
New
Ma et al., Changchun, China. In Int J Mol Med, Oct 2015
We found that the area under the curve (AUC) values of 8 miRNAs (miR-106a, miR-15a, miR-30a, miR-30b, miR-20a, miR-20b, miR-30d and miR-30e) and 8 mRNAs [axis inhibition protein 2 (AXIN2), integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) (ITGA3), tumor protein p53 inducible nuclear protein (TP53INP)1, TP53INP2, B-cell CLL/lymphoma 2 (BCL2), phosphatase and tensin homolog (PTEN), FOS and K(lysine) acetyltransferase 2B (KAT2B)] were >0.90.
Markers of autophagy are adapted to hyperglycaemia in skeletal muscle in type 2 diabetes.
New
Højlund et al., Odense, Denmark. In Diabetologia, Sep 2015
RESULTS: Muscle transcript levels of autophagy-related genes (ULK1, BECN1, PIK3C3, ATG5, ATG7, ATG12, GABARAPL1, MAP1LC3B, SQSTM1, TP53INP2 and FOXO3A [also known as FOXO3]), including some specific for mitophagy (BNIP3, BNIP3L and MUL1), and protein abundance of autophagy-related gene (ATG)7 and Bcl-2/adenovirus E1B 19-kDa-interacting protein 3 (BNIP3), as well as content and phosphorylation of forkhead box O3A (FOXO3A) were similar among the groups.
Is TP53INP2 a critical regulator of muscle mass?
Review
New
Zorzano et al., Madrid, Spain. In Curr Opin Clin Nutr Metab Care, May 2015
PURPOSE OF REVIEW: The main aim of this review is to summarize current knowledge of tumor protein p53-inducible nuclear protein 2 (TP53INP2) function and its role in skeletal muscle proteostasis.
miR-638 promotes melanoma metastasis and protects melanoma cells from apoptosis and autophagy.
New
Kunz et al., Leipzig, Germany. In Oncotarget, Mar 2015
mRNA expression profiling identified new candidate genes including TP53INP2 as miR-638 targets, the majority of which are involved in p53 signalling.
Identifying an essential role of nuclear LC3 for autophagy.
Liu et al., Hangzhou, China. In Autophagy, 2014
This relocation depends on a deacetylation of the protein by the activated nuclear deacetylase SIRT1 and the association of the protein with its nuclear interaction partner TP53INP2/DOR.
Neuroprotective Effect of Chebulagic Acid via Autophagy Induction in SH-SY5Y Cells.
Yang et al., Kangnŭng, South Korea. In Biomol Ther (seoul), 2014
We determined the effect of chebulagic acid on expression levels of autophago-some marker proteins such as, DOR/TP53INP2, Golgi-associated ATPase Enhancer of 16 kDa (GATE 16) and Light chain 3 II (LC3 II), as well as those of its upstream pathway proteins, AMP-activated protein kinase (AMPK), mammalian target of rapamycin (mTOR) and Beclin-1.
Autophagy-regulating TP53INP2 mediates muscle wasting and is repressed in diabetes.
Zorzano et al., In J Clin Invest, 2014
Here, we found that TP53INP2, a homolog of the Drosophila melanogaster DOR protein that regulates autophagy in cellular models, has a direct impact on skeletal muscle mass in vivo.
Potential Urinary Protein Biomarker Candidates for the Accurate Detection of Prostate Cancer among Benign Prostatic Hyperplasia Patients.
Haj-Ahmad et al., Canada. In J Cancer, 2013
This approach revealed that significant the down-regulation of Fibronectin and TP53INP2 was a characteristic event among PCa patients.
GPI transamidase and GPI anchored proteins: oncogenes and biomarkers for cancer.
Review
Hendrickson et al., Detroit, United States. In Crit Rev Biochem Mol Biol, 2013
In 2004, PIG-U, one of the subunits of GPI-T, was identified as an oncogene in bladder cancer, offering a direct connection between GPI-T and cancer.
Extrinsic and intrinsic regulation of DOR/TP53INP2 expression in mice: effects of dietary fat content, tissue type and sex in adipose and muscle tissues.
Baumgartner et al., Göttingen, Germany. In Nutr Metab (lond), 2011
UNLABELLED: BACKGROUND: DOR/TP53INP2 acts both at the chromosomal level as a nuclear co-factor e.g. for the thyroid hormone receptor and at the extrachromosomal level as an organizing factor of the autophagosome.
DOR/Tp53inp2 and Tp53inp1 constitute a metazoan gene family encoding dual regulators of autophagy and transcription.
GeneRIF
Zorzano et al., Barcelona, Spain. In Plos One, 2011
Mutation of conserved hydrophobic residues in region 1 of TP53inp2 reduces transcriptional activity, and blocks nuclear exit and autophagic activity under autophagy-activated conditions.
Purification and crystallization of yeast glycosylphosphatidylinositol transamidase subunit PIG-S (PIG-S(71-467)).
Grüber et al., Singapore, Singapore. In Acta Crystallogr Sect F Struct Biol Cryst Commun, 2011
The transfer of glycosylphosphatidylinositol (GPI) anchors onto eukaryotic proteins is catalyzed by the transamidase complex, which is composed of at least five subunits (PIG-K, PIG-S, PIG-T, PIG-U and GPAA1).
Role of diabetes- and obesity-related protein in the regulation of osteoblast differentiation.
GeneRIF
Mohan et al., Loma Linda, United States. In Am J Physiol Endocrinol Metab, 2011
DOR plays an important role in thyroid hormone-mediated osteoblast differentiation, and a DOR SNP associates with plasma osteocalcin in men.
Structural insight into the glycosylphosphatidylinositol transamidase subunits PIG-K and PIG-S from yeast.
Grüber et al., Singapore, Singapore. In J Struct Biol, 2011
The addition of glycosylphosphatidylinositol (GPI) anchors to eukaryotic proteins in the lumen of the endoplasmic reticulum is catalyzed by the transamidase complex, composed of at least five subunits (PIG-K, PIG-S, PIG-T, PIG-U and GPAA1).
Characterisation of hairy cell leukaemia by tiling resolution array-based comparative genome hybridisation: a series of 13 cases and review of the literature.
Review
Grandér et al., Stockholm, Sweden. In Eur J Haematol, 2010
In one case, a 700 kb deletion of 20q11.22 was detected encompassing ten characterised genes, among them the TP53INP2, DNCL2A and ITCH genes.
hnRNP A2 regulates alternative mRNA splicing of TP53INP2 to control invasive cell migration.
GeneRIF
Norman et al., Glasgow, United Kingdom. In Cancer Res, 2010
Alternative splicing of an exon in the 5' untranslated region of a gene termed TP53INP2 is a key event downstream of hnRNP A2 that is necessary for cells to invade the extracellular matrix.
The TP53INP2 protein is required for autophagy in mammalian cells.
GeneRIF
Iovanna et al., Marseille, France. In Mol Biol Cell, 2009
TP53INP2 is a novel gene involved in the autophagy of mammalian cells.
CDC91L1 (PIG-U) is a newly discovered oncogene in human bladder cancer.
Impact
Trink et al., Baltimore, United States. In Nat Med, 2004
We identified CDC91L1, the gene encoding CDC91L1 (also called phosphatidylinositol glycan class U (PIG-U), a transamidase complex unit in the glycosylphosphatidylinositol (GPI) anchoring pathway), as the only gene whose expression was affected by the translocation.
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