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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Dermcidin

PIF, proteolysis-inducing factor, PIF1, Dermcidin
This gene encodes a secreted protein that is subsequently processed into mature peptides of distinct biological activities. The C-terminal peptide is constitutively expressed in sweat and has antibacterial and antifungal activities. The N-terminal peptide, also known as diffusible survival evasion peptide, promotes neural cell survival under conditions of severe oxidative stress. A glycosylated form of the N-terminal peptide may be associated with cachexia (muscle wasting) in cancer patients. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, ACID, HAD, Ubiquitin, fibrillin-1
Papers on PIF
Cryptochromes Interact Directly with PIFs to Control Plant Growth in Limiting Blue Light.
New
Impact
Chory et al., Los Angeles, United States. In Cell, Feb 2016
Our results indicate that CRYs signal by modulating PIF activity genome wide and that these factors integrate binding of different plant photoreceptors to facilitate growth changes under different light conditions.
Tomato fruit carotenoid biosynthesis is adjusted to actual ripening progression by a light-dependent mechanism.
New
Rodriguez-Concepcion et al., Barcelona, Spain. In Plant J, Jan 2016
Work in Arabidopsis thaliana unveiled that transcription factors of the phytochrome-interacting factor (PIF) family regulate carotenoid gene expression in response to environmental signals (i.e.
Novel Development of a qPCR Assay Based on the rpoB Gene for Rapid Detection of Cronobacter spp.
New
Lu et al., Nanjing, China. In Curr Microbiol, Jan 2016
The sensitivity of the qPCR assay for pure culture and powdered infant formula (PIF) without enrichment was 3.44 log CFU/ml(g) (2.74 × 10(3) CFU/ml(g)).
TOPP4 Regulates the Stability of Phytochrome Interacting Factor 5 during Photomorphogenesis in Arabidopsis.
New
Hou et al., Lanzhou, China. In Plant Physiol, Jan 2016
However, the phosphatase responsible for PIF dephosphorylation remains unknown.
Characterization of the 5'-flanking region of the human TP53 gene and its response to the natural compound, Resveratrol.
New
Tanuma et al., Noda, Japan. In J Biochem, Jan 2016
A Luciferase assay showed that Rsv treatment increased the promoter activity of the TP53 gene in comparison to that of PIF1.
Immune regulatory and neuroprotective properties of preimplantation factor: From newborn to adult.
Review
New
Paidas et al., Cherry Hill, United States. In Pharmacol Ther, Dec 2015
The role of PreImplantation Factor (PIF) within this context is herein examined.
Rapid detection of Cronobacter sakazakii by real-time PCR based on the cgcA gene and TaqMan probe with internal amplification control.
New
Wu et al., Guangzhou, China. In Can J Microbiol, Dec 2015
UNASSIGNED: Cronobacter sakazakii is a severe virulent strain that is frequently detected in powdered infant formula (PIF).
Illuminating Progress in Phytochrome-Mediated Light Signaling Pathways.
Review
New
Huq et al., Austin, United States. In Trends Plant Sci, Oct 2015
These include the identification of E3 ligases that degrade PHYTOCHROME INTERACTING FACTOR (PIF) proteins, key negative regulators, in response to light, a better view of how phytochromes inhibit another key negative regulator, CONSTITUTIVELY PHOTOMORPHOGENIC 1 (COP1), and an understanding of why plants evolved multiple negative regulators to repress photomorphogenesis in darkness.
Advances in understanding cis regulation of the plant gene with an emphasis on comparative genomics.
Review
New
Freeling et al., Berkeley, United States. In Curr Opin Plant Biol, Oct 2015
Molecular genetics with model plants continues to make advances; highlighted here are quantitative-occupancy results from the Arabidopsis thaliana (Arabidopsis) Phytochrome-Interacting bHLH transcription Factors (PIF) quartet.
New mechanistic links between sugar and hormone signalling networks.
Review
New
Perata et al., Umeå, Sweden. In Curr Opin Plant Biol, Jun 2015
In this work, DELLA and PIF proteins have emerged as hubs in sugar-hormone cross-regulation networks.
Borrowing nuclear DNA helicases to protect mitochondrial DNA.
Review
Liu et al., Duarte, United States. In Int J Mol Sci, 2014
To date, these helicases include RecQ-like helicase 4 (RECQ4), petite integration frequency 1 (PIF1), DNA replication helicase/nuclease 2 (DNA2) and suppressor of var1 3-like protein 1 (SUV3).
Pif1 family helicases suppress genome instability at G-quadruplex motifs.
Impact
Zakian et al., Princeton, United States. In Nature, 2013
The Saccharomyces cerevisiae Pif1 helicase is the prototypical member of the Pif1 DNA helicase family, which is conserved from bacteria to humans.
Photoreceptor signaling networks in plant responses to shade.
Review
Impact
Casal, Buenos Aires, Argentina. In Annu Rev Plant Biol, 2012
Direct PIF interaction with DELLA proteins links gibberellin and brassinosteroid signaling to shade avoidance.
The identification of a new role for LEKTI in the skin: The use of protein 'bait' arrays to detect defective trafficking of dermcidin in the skin of patients with Netherton syndrome.
GeneRIF
Mills et al., London, United Kingdom. In J Proteomics, 2012
major binding partners of LEKTI were found to be the antimicrobial peptide dermcidin and the serine protease cathepsin G and no kallikreins.
Structure-activity analysis of the dermcidin-derived peptide DCD-1L, an anionic antimicrobial peptide present in human sweat.
GeneRIF
Schittek et al., Tübingen, Germany. In J Biol Chem, 2012
Structure-activity analysis of the dermcidin-derived peptide DCD-1L, an anionic antimicrobial peptide present in human sweat.
A genomewide screen for suppressors of Alu-mediated rearrangements reveals a role for PIF1.
GeneRIF
Welcsh et al., Seattle, United States. In Plos One, 2011
PIF1 variant L319P was identified in three breast cancer families
Suppression of apoptosis by PIF1 helicase in human tumor cells.
GeneRIF
Meuth et al., Sheffield, United Kingdom. In Cancer Res, 2011
Findings suggest roles for PIF1 in S-phase entry and progression that are essential to protect human tumor cells from apoptosis.
The PIAS homologue Siz2 regulates perinuclear telomere position and telomerase activity in budding yeast.
Impact
Gasser et al., Basel, Switzerland. In Nat Cell Biol, 2011
Remarkably, loss of Siz2 also provokes telomere extension in a telomerase-dependent manner that is epistatic with loss of the helicase Pif1.
Identification of Dermcidin as a novel binding protein of Nck1 and characterization of its role in promoting cell migration.
GeneRIF
Nie et al., Guangzhou, China. In Biochim Biophys Acta, 2011
revealed that Nck1 SH2 domain binds to the phosphotyrosine residue at position 20 (Y20) of the DCD
DNA damage signalling prevents deleterious telomere addition at DNA breaks.
Impact
Blackburn et al., San Francisco, United States. In Nat Cell Biol, 2009
After DNA damage, MEC1-RAD53-DUN1-dependent phosphorylation of the telomerase inhibitor Pif1 occurs.
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