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Metastasis associated 1 family, member 2

This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis. [provided by RefSeq, May 2011] (from NCBI)
Top mentioned proteins: CAN, HAD, AGE, ACID, V1a
Papers on PID
Two-degree-of-freedom fractional order-PID controllers design for fractional order processes with dead-time.
Zhang et al., Shenyang, China. In Isa Trans, Feb 2016
UNASSIGNED: Recently, fractional order (FO) processes with dead-time have attracted more and more attention of many researchers in control field, but FO-PID controllers design techniques available for the FO processes with dead-time suffer from lack of direct systematic approaches.
Gene therapy for primary immunodeficiencies.
Cavazzana et al., Paris, France. In Clin Genet, Dec 2015
Gene therapy has effectively entered Medicine via the field of primary immunodeficiencies (PID).
Epigenetic regulation of autophagy by the methyltransferase EZH2 through an MTOR-dependent pathway.
Zhu et al., Beijing, China. In Autophagy, Nov 2015
EZH2 was recruited to these genes promoters via MTA2 (metastasis associated 1 family, member 2), a component of the nucleosome remodeling and histone deacetylase (NuRD) complex.
Heart rate regulation during cycle-ergometer exercise via bio-feedback.
Celler et al., In Conf Proc Ieee Eng Med Biol Soc, Aug 2015
The controller is indeed a non-conventional non-model-based proportional, integral and derivative (PID) controller.
Closed-loop controller for chest compressions based on coronary perfusion pressure: a computer simulation study.
Wang et al., Tianjin, China. In Med Biol Eng Comput, Aug 2015
Compared with a traditional proportion-integration-differentiation (PID) controller, the performance of the fuzzy controller is evaluated in computer simulation studies.
Dysfunction of the Reciprocal Feedback Loop between GATA3- and ZEB2-Nucleated Repression Programs Contributes to Breast Cancer Metastasis.
Shang et al., Beijing, China. In Cancer Cell, Jul 2015
Here, we report that GATA3 nucleates a transcription repression program composed of G9A and MTA3-, but not MTA1- or MTA2-, constituted NuRD complex.
Expression of MTA2 and Ki-67 in hepatocellular carcinoma and their correlation with prognosis.
Zhang et al., Shanghai, China. In Int J Clin Exp Pathol, 2014
The aim of this study was to investigate the relationship among MTA2, Ki-67 and HCC patient prognosis.
Novel Genome-Editing Tools to Model and Correct Primary Immunodeficiencies.
Musunuru et al., Boston, United States. In Front Immunol, 2014
Severe combined immunodeficiency (SCID) and other severe non-SCID primary immunodeficiencies (non-SCID PID) can be treated by allogeneic hematopoietic stem cell (HSC) transplantation, but when histocompatibility leukocyte antigen-matched donors are lacking, this can be a high-risk procedure.
Signal Integration during T Lymphocyte Activation and Function: Lessons from the Wiskott-Aldrich Syndrome.
Vasconcelos et al., Rio de Janeiro, Brazil. In Front Immunol, 2014
Over the last decades, research dedicated to the molecular and cellular mechanisms underlying primary immunodeficiencies (PID) has helped to understand the etiology of many of these diseases and to develop novel therapeutic approaches.
[A therapeutic approach towards chronic granulomatous disease].
Kawai, In Nihon Rinsho Meneki Gakkai Kaishi, 2013
Chronic granulomatous disease (CGD) is a primary immunodeficiency (PID) characterized by the inability of phagocytes to produce reactive oxygen intermediates (ROIs) due to a defect in the NADPH oxidase complex.
Phosphoinositide 3-kinase δ gene mutation predisposes to respiratory infection and airway damage.
Nejentsev et al., Cambridge, United Kingdom. In Science, 2013
Here, we describe activated PI3K-δ syndrome (APDS), a PID associated with a dominant gain-of-function mutation in which lysine replaced glutamic acid at residue 1021 (E1021K) in the p110δ protein, the catalytic subunit of phosphoinositide 3-kinase δ (PI3Kδ), encoded by the PIK3CD gene.
Expression of metastasis-associated protein 2 (MTA2) might predict proliferation in non-small cell lung cancer.
Dai et al., Shenyang, China. In Target Oncol, 2012
Our data suggested that MTA2 might play roles in both the nucleus and cytoplasm in the progression of NSCLC.
Risk of ovarian cancer in women with pelvic inflammatory disease: a population-based study.
Lai et al., Taipei, Taiwan. In Lancet Oncol, 2011
Pelvic inflammatory disease (PID) has been suggested to increase the risk of developing ovarian cancer, but the results of studies have been inconsistent.
Light-mediated polarization of the PIN3 auxin transporter for the phototropic response in Arabidopsis.
Friml et al., Gent, Belgium. In Nat Cell Biol, 2011
In the dark, high expression and activity of the PINOID (PID) kinase correlates with apolar targeting of PIN3 to all cell sides.
[Interaction between the PINOID/ABRUPTUS gene with the AGAMOUS gene: the negative regulator of stem cells in the meristem of Arabidopsis thaliana flower].
Ezhova et al., In Ontogenez, 2011
Interaction between the PINOID/ABRUPTUS gene with the AGAMOUS gene: the negative regulator of stem cells in the meristem of Arabidopsis thaliana flower
Metastasis tumor antigen 2 (MTA2) is involved in proper imprinted expression of H19 and Peg3 during mouse preimplantation development.
Schultz et al., Philadelphia, United States. In Biol Reprod, 2010
investigation of expression/role of Mta2 in zygote/blastocyst development: Mta2 appears to be only Mta expressed in zygotes; Mta2 appears to control transcription/expression of H19 and Peg3 in blastocysts; Mta2 may be involved in genetic imprinting
Plasma membrane-bound AGC3 kinases phosphorylate PIN auxin carriers at TPRXS(N/S) motifs to direct apical PIN recycling.
Offringa et al., Utrecht, Netherlands. In Development, 2010
show that PID, WAG1 and WAG2, and not other plant AGC kinases, instruct recruitment of PINs into the apical recycling pathway by phosphorylating the middle serine in three conserved TPRXS(N/S) motifs within the PIN central hydrophilic loop
[Expression and significance of MTA2 in non-small cell lung cancer].
Qiu et al., Shenyang, China. In Zhongguo Fei Ai Za Zhi, 2010
The expression of MTA2 had positive correlation with clinical stage and lymph node metastasis.
Human primary immunodeficiency diseases.
Fischer, Paris, France. In Immunity, 2007
Primary immunodeficiency diseases (PID) provide invaluable insight into immune system, notably in vivo immune responses to microorganisms as based on the variable vulnerability to pathogens and opportunistic agents.
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