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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Protein interacting with PRKCA 1

PICK1, Ca-binding protein, protein interacting with C kinase 1
PDZ domain containing protein; interacts with C-terminal domain of many central nervous system receptor proteins; may have an important role in signal transduction during synaptic transmission [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: GluR2, ACID, V1a, CAN, PSD-95
Papers on PICK1
Willed-movement training reduces brain damage and enhances synaptic plasticity related proteins synthesis after focal ischemia.
New
Li et al., Changsha, China. In Brain Res Bull, Jan 2016
Infarct volume by 2,3,5-triphenyltetrazolium chloride (TTC) dye, expression of PICK1 and synaptophysin in cerebral cortex and striatum of injured side by western blotting and immunofluorescence performed are analyzed.
Identification of a new DPY19L2 mutation and a better definition of DPY19L2 deletion breakpoints leading to globozoospermia.
New
Viville et al., Sousse, Tunisia. In Mol Hum Reprod, Jan 2016
WHAT IS KNOWN ALREADY: Three genes [spermatogenesis associated 16 (SPATA16), protein interacting with PRKCA (PICK1) and DPY19L2] were previously correlated with globozoospermia, but a homozygous deletion of the entire DPY19L2 was identified as the most frequent alteration causing this phenotype.
PICK1/Calcineurin Suppress ASIC1-mediated Ca2+ Entry in Rat Pulmonary Arterial Smooth Muscle Cells.
New
Jernigan et al., Mexico. In Am J Physiol Cell Physiol, Jan 2016
ASIC1 binds the PDZ (PSD-95/Dlg/ZO-1) domain of the protein interacting with C kinase 1 (PICK1) and this interaction is important for the subcellular localization and/or activity of ASIC1.
Protein interacting with C kinase 1 suppresses invasion and anchorage-independent growth of astrocytic tumor cells.
New
Hanley et al., Bristol, United Kingdom. In Mol Biol Cell, Jan 2016
Protein interacting with C kinase 1 (PICK1) is a PDZ and BAR domain-containing protein that inhibits actin-related protein 2/3 (Arp2/3)-dependent actin polymerization and is involved in regulating the trafficking of a number of cell-surface receptors.
Glycogen Synthase Kinase 3β-mediated Phosphorylation in the Most C-terminal Region of Protein Interacting with C Kinase 1 (PICK1) Regulates the Binding of PICK1 to Glutamate Receptor Subunit GluA2.
New
Takashima et al., Wako, Japan. In J Biol Chem, Jan 2016
Protein interacting with C kinase 1 (PICK1) is a synaptic protein interacting with the AMPA receptor subunits GluA2/3.
Protein Interacting C-Kinase 1 Modulates Surface Expression of P2Y6 Purinoreceptor, Actin Polymerization and Phagocytosis in Microglia.
New
Li et al., Jiaxing, China. In Neurochem Res, Dec 2015
PICK1 (protein interacting with C-kinase-1) interacts with various neurotransmitter receptors, transporters, and enzymes.
Enhancement of acid-sensing ion channel activity by metabotropic P2Y UTP receptors in primary sensory neurons.
New
Hu et al., Xianning, China. In Purinergic Signal, Dec 2015
Potentiation of UTP was blocked by P2Y receptor antagonist suramin and by inhibition of intracellular G protein, phospholipase C (PLC), protein kinase C (PKC), or protein interacting with C-kinase 1 (PICK1) signaling.
Ablation of HRC alleviates cardiac arrhythmia and improves abnormal Ca handling in CASQ2 knockout mice prone to CPVT.
New
Györke et al., Columbus, United States. In Cardiovasc Res, Dec 2015
AIMS: Cardiac calsequestrin (CASQ2) and histidine-rich Ca-binding protein (HRC) are sarcoplasmic reticulum (SR) Ca-binding proteins that regulate SR Ca release in mammalian heart.
Genetic aspects of monomorphic teratozoospermia: a review.
Review
New
Perrin et al., Brest, France. In J Assist Reprod Genet, Apr 2015
Mutations or deletions in three genes, SPATA16, PICK1 and DPY19L2, have been shown to be responsible for globozoospermia.
Down-regulation of ASICs current and the calcium transients by disrupting PICK1 protects primary cultured mouse cortical neurons from OGD-Rep insults.
Ye et al., China. In Int J Clin Exp Pathol, 2014
ASICs activation involving in glutamate receptor-independent ischemic brain injury has been generally accepted, and PICK1 is recently shown to be one of partner proteins interacting with ASICs through its PDZ domain.
Membrane Binding and Modulation of the PDZ Domain of PICK1.
Review
Madsen et al., Copenhagen, Denmark. In Membranes (basel), 2014
Moreover, we review how these PDZ-membrane interactions are regulated in the case of the synaptic scaffolding protein PICK1 and how this might affect cellular localization and function.
Protein interacting with C kinase and neurological disorders.
Review
Hermans et al., Brussels, Belgium. In Synapse, 2013
Best known for its interaction with the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor subunit GluA2 and for its influence on excitatory synapse activity, the protein interacting with C kinase, PICK1, is the focus of considerable attention from neurobiologists.
Molecular cytogenetic and genetic aspects of globozoospermia: a review.
Review
De Braekeleer et al., Brest, France. In Andrologia, 2013
Mutations or deletions in three genes, SPATA16, PICK1 and DPY19L2, have been shown to be responsible for globozoospermia.
PICK1 mediates transient synaptic expression of GluA2-lacking AMPA receptors during glycine-induced AMPA receptor trafficking.
GeneRIF
Hanley et al., Bristol, United Kingdom. In J Neurosci, 2012
The data of this study demonstrated that a PICK1-GRIP1-GluA2 complex is involved in the regulation of GluA2 trafficking after glycine stimulation and therefore suggest that this complex is involved in these processes during LTP expression.
Modulation of cardiac contractility by the phospholamban/SERCA2a regulatome.
Review
Hajjar et al., Cincinnati, United States. In Circ Res, 2012
However, the initial simple view of a PLN/SERCA regulatory complex has been modified by our recent identification of SUMO, S100 and the histidine-rich Ca-binding protein as regulators of SERCA activity.
The binding affinities of proteins interacting with the PDZ domain of PICK1.
GeneRIF
Dev et al., Tempe, United States. In Proteins, 2012
The binding affinities of all major PICK1 interacting proteins are reported and the effects of PICK1 mutations on these interactions are described.
Protein interacting with C kinase 1 (PICK1) reduces reinsertion rates of interaction partners sorted to Rab11-dependent slow recycling pathway.
GeneRIF
Gether et al., Copenhagen, Denmark. In J Biol Chem, 2012
Our data suggest a selective role of PICK1 in clustering and reducing the recycling rates of PDZ domain binding partners sorted to the Rab11-dependent recycling pathway.
Serine 77 in the PDZ domain of PICK1 is a protein kinase Cα phosphorylation site regulated by lipid membrane binding.
GeneRIF
Madsen et al., Copenhagen, Denmark. In Biochemistry, 2012
PICK1 is phosphorylated at Ser77 by PKCalpha preferentially when bound to membrane vesicles
Protein interacting with C kinase (PICK1) is a suppressor of spinocerebellar ataxia 3-associated neurodegeneration in Drosophila.
GeneRIF
Bonini et al., Philadelphia, United States. In Hum Mol Genet, 2012
PICK1 is a suppressor of spinocerebellar ataxia 3-associated neurodegeneration.
Inhibition of Arp2/3-mediated actin polymerization by PICK1 regulates neuronal morphology and AMPA receptor endocytosis.
Impact
GeneRIF
Hanley et al., Bristol, United Kingdom. In Nat Cell Biol, 2008
PICK1 is a negative regulator of Arp2/3-mediated actin polymerization that is critical for a specific form of vesicle trafficking, and also for the development of neuronal architecture
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