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Protein inhibitor of activated STAT, 3

PIAS3, protein inhibitor of activated STAT3
This gene encodes a member of the PIAS [protein inhibitor of activated STAT (signal transducer and activator of transcription)] family of transcriptional modulators. The protein functions as a SUMO (small ubiquitin-like modifier)-E3 ligase which catalyzes the covalent attachment of a SUMO protein to specific target substrates. It directly binds to several transcription factors and either blocks or enhances their activity. Alternatively spliced transcript variants of this gene have been identified, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Papers on PIAS3
Protein inhibitor of activated STAT3 (PIAS3) protein promotes SUMOylation and nuclear sequestration of the intracellular domain of ErbB4 protein.
Elenius et al., Turku, Finland. In J Biol Chem, 2012
PIAS3 is a novel regulator of ErbB4 receptor tyrosine kinase, controlling its nuclear sequestration and function.
NF-κB repression by PIAS3 mediated RelA SUMOylation.
Kulesz-Martin et al., Portland, United States. In Plos One, 2011
NF-kappaB is regulated through a novel negative feedback mechanism by SUMOylation, where the RelA subunit of NF-kappaB is SUMOylated by PIAS3.
The PINIT domain of PIAS3: structure-function analysis of its interaction with STAT3.
Blatch et al., Grahamstown, South Africa. In J Mol Recognit, 2011
L97A, R99N and R99Q mutations of the PINIT domain (PIAS3(85-272) ) were found to abrogate binding to STAT3, suggesting that these residues were part of a potential binding surface.
Identification of STAT3-independent regulatory effects for protein inhibitor of activated STAT3 by binding to novel transcription factors.
Dowlati et al., Cleveland, United States. In Cancer Biol Ther, 2011
novel transcription factor binding partners for PIAS3 including ETS, EGR1, NR1I2, and GATA1 were identified.
Protein inhibitor of activated STAT3 expression in lung cancer.
Dowlati et al., Cleveland, United States. In Mol Oncol, 2011
Squamous cell carcinoma of the lung commonly lacks PIAS3 protein expression.
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