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Phosphoinositide-3-kinase, catalytic, beta polypeptide

PI3K, p110beta
This gene encodes an isoform of the catalytic subunit of phosphoinositide 3-kinase (PI3K). These kinases are important in signaling pathways involving receptors on the outer membrane of eukaryotic cells and are named for their catalytic subunit. The encoded protein is the catalytic subunit for PI3Kbeta (PI3KB). PI3KB has been shown to be part of the activation pathway in neutrophils which have bound immune complexes at sites of injury or infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011] (from NCBI)
Top mentioned proteins: Akt, V1a, mTOR, CAN, MAPK
Papers using PI3K antibodies
Signal transducer and activator of transcription 3 (STAT3) and Suppressor of Cytokine Signaling (SOCS3) balance controls cytotoxicity and IL-10 expression in decidual-like natural killer cell line NK-92
Jacobs Roland, In PLoS ONE, 2010
... phospho-MAPKp44/42, anti-human SOCS3, anti-human phosphor-STAT3 antibodies, the U0126 (inhibitor of ERK1/2) and wortmannin (inhibitor of PI3K) were obtained from Cell Signaling Technology (Boston, MA, USA) ...
Decreased Level of PDCD4 (Programmed Cell Death 4) Protein Activated Cell Proliferation in the Lung of A/J Mouse.
Hotchin Neil A., In PLoS ONE, 2009
... Phosphoinositide 3-kinase (PI3K) inhibitor LY294002 (Cell Signaling Technology Inc., Danvers, MA), ...
Simultaneous determination of baicalin, baicalein, wogonin, berberine, palmatine and jatrorrhizine in rat plasma by liquid chromatography-tandem mass spectrometry and application in pharmacokinetic studies after oral administration of traditional Chinese medicinal preparations containing scutellaria-coptis herb couple
Ma Jin Yeul et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2009
... RIPA buffer and PI3K inhibitor, LY294002, were obtained from Millipore (Billerica, MA, USA) and Cell Signaling (Danver, MA, USA), respectively ...
Age- and diet-specific effects of variation at S6 kinase on life history, metabolic, and immune response traits in Drosophila melanogaster.
Harrison Jeffrey K., In PLoS ONE, 2009
... Phospho-S270 of IRS-1 and PI3k-p85a antibody were obtained from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Estrogen receptor-alpha (ER-alpha) suppresses expression of its variant ER-alpha 36
Wang Zhao-Yi et al., In Oncogene, 2008
... The MEK1/2 inhibitor U0126, the Src inhibitor PP2, and the PI3K inhibitor LY294002 were from Tocris Bioscience (Ellisville, MO) ...
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Papers on PI3K
Facilitative glucose transporters: Implications for cancer detection, prognosis and treatment.
Tsiani et al., Canada. In Metabolism, Feb 2016
The regulation of GLUTs by key proliferation and pro-survival pathways including the phosphatidylinositol 3-kinase (PI3K)-Akt, hypoxia-inducible factor-1 (HIF-1), Ras, c-Myc and p53 pathways is discussed.
Prevention of Venous Neointimal Hyperplasia by a Multitarget Receptor Tyrosine Kinase Inhibitor.
Cheung et al., Salt Lake City, United States. In J Vasc Res, Feb 2016
Sunitinib inhibited PDGF-stimulated proliferation, migration, phosphorylation of MAPK and PI3K/Akt proteins and changes in the expression of cell-cycle regulatory proteins in vascular smooth-muscle cells as well as VEGF-stimulated endothelial cell proliferation in vitro.
Leptin signalling pathways in hypothalamic neurons.
Kim et al., Seoul, South Korea. In Cell Mol Life Sci, Feb 2016
The signaling pathways known to mediate the actions of leptin include JAK-STAT signaling, PI3K-Akt-FoxO1 signaling, SHP2-ERK signaling, AMPK signaling, and mTOR-S6K signaling.
p53 Reactivation by PRIMA-1(Met) (APR-246) sensitises (V600E/K)BRAF melanoma to vemurafenib.
Ghanem et al., Brussels, Belgium. In Eur J Cancer, Feb 2016
UNASSIGNED: Intrinsic and acquired resistance of metastatic melanoma to (V600E/K)BRAF and/or MEK inhibitors, which is often caused by activation of the PI3K/AKT survival pathway, represents a major clinical challenge.
Nudging Oligodendrocyte Intrinsic Signaling to Remyelinate and Repair: Estrogen Receptor Ligand Effects.
Tiwari-Woodruff et al., Riverside, United States. In J Steroid Biochem Mol Biol, Feb 2016
At the intracellular signaling level, transition of early to late OPCs requires Erk1/2 signaling, and transition of immature to mature OLs requires mTOR signaling; thus, the PI3K/Akt/mTOR pathway plays a major role in the late stages of OL differentiation and myelination.
Long-Term ERK Inhibition in KRAS-Mutant Pancreatic Cancer Is Associated with MYC Degradation and Senescence-like Growth Suppression.
Der et al., Chapel Hill, United States. In Cancer Cell, Feb 2016
We determined that direct pharmacologic inhibition of ERK suppressed the growth of a subset of KRAS-mutant pancreatic cancer cell lines and that concurrent phosphatidylinositol 3-kinase (PI3K) inhibition caused synergistic cell death.
Genomics of Immune Diseases and New Therapies.
Lucas et al., Bethesda, United States. In Annu Rev Immunol, Jan 2016
At the end, we discuss two other recently described diseases, PASLI (PI3K dysregulation) and CHAI/LATAIE (CTLA-4 deficiency), as additional examples of the journey from unknown immunological diseases to new precision medicine treatments using genomics.
PI3 Kinase and FOXO1 Transcription Factor Activity Differentially Control B Cells in the Germinal Center Light and Dark Zones.
Rajewsky et al., Berlin, Germany. In Immunity, Jan 2016
Phosphatidylinositol 3' OH kinase (PI3K) signaling and FOXO transcription factors play opposing roles at several B cell developmental stages.
Apocynin and Diphenyleneiodonium Induce Oxidative Stress and Modulate PI3K/Akt and MAPK/Erk Activity in Mouse Embryonic Stem Cells.
Pacherník et al., Brno, Czech Republic. In Oxid Med Cell Longev, Dec 2015
Further, we revealed that apocynin inhibits PI3K/Akt pathway with its downstream transcriptional factor Nanog. Opposite to this, apocynin augmented activity of canonical Wnt signaling.
Pro-apoptotic and anti-proliferative effects of mitofusin-2 via PI3K/Akt signaling in breast cancer cells.
Liu et al., Shijiazhuang, China. In Oncol Lett, Dec 2015
Additionally, the PI3K/Akt signaling pathway was analyzed after pEGFP-Mfn2 was transfected into MCF-7 cells.
Molecular biology of anal squamous cell carcinoma: implications for future research and clinical intervention.
Phillips et al., Melbourne, Australia. In Lancet Oncol, Dec 2015
Regulators of apoptosis, including survivin, and agents targeting the PI3K/AKT pathway, offer opportunities for targeted therapy, although robust data are scarce.
PI3K/Akt/mTOR inhibitors in breast cancer.
Yap et al., Singapore, Singapore. In Cancer Biol Med, Dec 2015
Activation of the phosphoinositide 3 kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway is common in breast cancer.
The Dlk1-Gtl2 Locus Preserves LT-HSC Function by Inhibiting the PI3K-mTOR Pathway to Restrict Mitochondrial Metabolism.
Li et al., Kansas City, United States. In Cell Stem Cell, Dec 2015
Mechanistically, the miRNA mega-cluster within the Dlk1-Gtl2 locus suppresses the entire PI3K-mTOR pathway.
Activated Integrin-Linked Kinase Negatively Regulates Muscle Cell Enhancement Factor 2C in C2C12 Cells.
Cang et al., Hohhot, China. In Biomed Res Int, 2014
In the present investigation, we explored whether ILK activation depended on PI3K to regulate the phosphorylation and transcriptional activity of MEF2C during C2C12 cell proliferation.
Signaling crosstalk between the mTOR complexes.
Proud et al., Southampton, United Kingdom. In Translation (austin), 2013
For instance, both mTORC1 and 2 share some common upstream signaling molecules, such as PI3K and tuberous sclerosis complex TSC, which control their activation.
The p110α and p110β isoforms of PI3K play divergent roles in mammary gland development and tumorigenesis.
Zhao et al., Boston, United States. In Genes Dev, 2012
a novel p110beta-based regulatory role in receptor-mediated PI3K activity and identify p110alpha as an important target for treatment of HER2-positive disease.
Both p110α and p110β isoforms of PI3K can modulate the impact of loss-of-function of the PTEN tumour suppressor.
Vanhaesebroeck et al., London, United Kingdom. In Biochem J, 2012
In primary and immortalized mouse fibroblast cell lines, both p110alpha and p110beta controlled steady-state PtdIns(3,4,5)P3 levels and Akt signalling induced by heterozygous PTEN loss.
Silencing p110β prevents rapid depletion of nuclear pAkt.
Stenius et al., Stockholm, Sweden. In Biochem Biophys Res Commun, 2012
data show that p110beta is essential for the ATP- and statin-induced effects and support a role of nuclear pAkt in cancer development.
Combined blockade of ADP receptors and PI3-kinase p110β fully prevents platelet and leukocyte activation during hypothermic extracorporeal circulation.
Straub et al., Tübingen, Germany. In Plos One, 2011
Combined blockade of P2Y12, P2Y1 and PI3-kinase p110beta fully prevents platelet and leukocyte activation during hypothermic extracorporeal circulation.
The acute effects of leptin require PI3K signaling in the hypothalamic ventral premammillary nucleus.
Elias et al., Dallas, United States. In J Neurosci, 2011
results suggest that PI3K signaling in LepR PMV neurons is essential for leptin-induced alteration in cellular activity.
More papers using PI3K antibodies
Nuclear factor-κB signaling: a contributor in leukemogenesis and a target for pharmacological intervention in human acute myelogenous leukemia
Bruserud Øystein et al., In Bone Marrow Research, 2008
... The PI3K inhibitor 3-methyladenine (3-MA) and the specific IκB-kinase/NFκB inhibitor BMS-345541 were purchased from Sigma Aldrich (St ...
Non-Smad pathways in TGF-beta signaling
Spessotto Paola et al., In The Journal of Cell Biology, 2008
... Ser465/467 and linker region Ser245/250/255), anti-Smad2/3, anti–phospho-Akt (Thr308 and Ser 473), anti-Akt, anti-PTEN, and anti–PI3K p110-α antibodies were obtained from Cell Signaling Technology ...
Autophagy fights disease through cellular self-digestion
Wang Fen et al., In International Journal of Biological Sciences, 2007
... (Camarillo, CA), and PI3K (LY294002) was from Cell Signaling (Beverly, MA) ...
Optimization of Parameters for Semiempirical Methods V: Modification of NDDO Approximations and Application to 70 Elements
Kuboyama Tomoharu et al., In Scientific Reports, 2006
... The phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 (Cayman Chemicals), MEK1 inhibitor PD98059 ...
Transactivation and signaling functions of Tat are not correlated: biological and immunological characterization of HIV-1 subtype-C Tat protein.
Kashanchi Fatah, In PLoS ONE, 2005
... (bFGF), epidermal growth factor (EGF), poly-D-lysine (PDL), Dulbecco's modified Eagle's medium (DMEM), morphine sulphate, specific PI3K inhibitor LY294002, etoposide and naloxone hydrochloride were all purchased from Sigma Aldrich (St ...
alpha-TEA inhibits survival and enhances death pathways in cisplatin sensitive and resistant human ovarian cancer cells
Kline K et al., In British Journal of Cancer, 2005
... Map kinase kinase (MEK) inhibitor (U01260) and PI3K inhibitor (wortmannin) were purchased from Cell Signaling Technology (Beverly, MA, USA) ...
Src kinase regulation by phosphorylation and dephosphorylation
Migliaccio Antimo, In PLoS ONE, 2004
... The Src inhibitor PP2, the EGFR inhibitor AG1478 and the PI3K inhibitor LY294002 were from Tocris Bioscience (Ellisville, MO) ...
FGF-23–Klotho signaling stimulates proliferation and prevents vitamin D–induced apoptosis
Lanske Beate et al., In The Journal of Cell Biology, 2004
... Azam, Harvard Medical School, Boston, MA) and PI3K (LY294002; Cell Signaling Technology) inhibitors were added ...
Targeting I kappa B kinase for the treatment of inflammatory and other disorders
Baharav Ehud et al., In Arthritis Research & Therapy, 2002
... AR and the signaling proteins PI3K, IKKα/β, were purchased from Santa Cruz Biotechnology Inc ...
Thioredoxin-mediated redox control of the transcription factor Sp1 and regulation of the thioredoxin gene promoter.
Cordes Nils, In PLoS ONE, 2002
... The general PI3K inhibitor, LY294002, was from Cell Signaling Biotechnology ...
The biological action of saponins in animal systems: a review.
Means Robert E., In PLoS ONE, 2001
... Antibodies against PI3K and phosphorylated PI3K were purchased from Cell Signaling Technology (Danvers, MA) ...
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.
Pesce Maurizio, In PLoS ONE, 2000
... Louis, MO, USA); the PI3K inhibitor LY294002 and the PAFR human polyclonal antibody from Cayman Chemical (Ann Arbor, Michigan, ...
A homeodomain protein code specifies progenitor cell identity and neuronal fate in the ventral neural tube
Farrar William L et al., In Molecular Cancer, 1999
... The following inhibitors were also used: Anti-human IL-6 antibody (R&D Systems, Minneapolis, MN), PI3K inhibitor LY294002 (Cell Signaling, Danvers, MA), Tec Kinase ...
The EGF receptor as central transducer of heterologous signalling systems.
Hong Wanjin, In PLoS ONE, 1998
... The Src inhibitors PP2, the PI3K inhibitor LY294002, 4-hydoxy tamoxifen (4-OHT) and ICI 182, 780 were from Tocris Bioscience (Ellisville, MO) ...
Vav3 Modulates B Cell Receptor Responses by Regulating Phosphoinositide 3-Kinase Activation
Kurosaki Tomohiro et al., In The Journal of Experimental Medicine, 1997
... purchased: anti-phosphotyrosine mAb (4G10), anti-Rac1 mAb, and rabbit anti-PI3K p85 Abs from Upstate Biotechnology, goat anti-PI3K p110α Abs (sc-1331) and goat anti-Akt1 Abs (sc-1618) from Santa Cruz Biotechnology, Inc., anti-c-Jun NH ...
Tumor necrosis factor-alpha in sera of obese patients: fall with weight loss
Goalstone Marc L et al., In Journal of Inflammation (London, England), 1997
... Kinase inhibitors PD98059 (for MEK1/2) and Wortmannin (for PI3K) were from Cell Signaling (Danvers, MA) ...
Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)
Cantrell Doreen et al., In The Journal of Cell Biology, 1995
... The PI3K inhibitor LY294002 was purchased from BIOMOL Research Laboratories, the histone ...
Positional cloning of the mouse obese gene and its human homologue
Abdel-Aal Abeer Abdel-Alim et al., In Journal of Veterinary Science, 1993
... Wortmannin (WT; a PI3K inhibitor) was from Biomol Research Laboratories (USA) ...
Eosinophil transendothelial migration induced by cytokines. I. Role of endothelial and eosinophil adhesion molecules in IL-1 beta-induced transendothelial migration
Heinemann Akos et al., In Cellular and Molecular Life Sciences, 1991
... The adenylyl cyclase inhibitor SQ22536, the PI3K inhibitor LY294002 and the PKC inhibitor chelerythrine were supplied from Biomol (Hamburg, Germany) ...
Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays
Peppelenbosch M P et al., In Cell Death & Disease, 1991
... The PI3K inhibitor LY294002 was from Alexis (Läufelingen, Switzerland) and TNFα was from Biovision Inc ...
Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death
Belkhiri Abbes, In PLoS ONE, 1989
... The PI3K siRNA kit was procured from Santa Cruz Biotechnology, Inc ...
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