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Phospholipase C, beta 1

PI-PLC, ERp57, phospholipase Cbeta
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: PLC, CAN, V1a, calreticulin, ACID
Papers on PI-PLC
Plant Phospholipases D and C and Their Diverse Functions in Stress Responses.
Wang et al., Wuhan, China. In Prog Lipid Res, Feb 2016
PLDs and PLCs in plants occur in different forms: the calcium-dependent phospholipid binding domain-containing PLDs (C2-PLDs), the plekstrin homology and phox homology domain-containing PLDs (PX/PH-PLDs), phosphoinositide-specific PLC (PI-PLC), and non-specific PLC (NPC).
Efficient induction of cross-presentating human B cell by transduction with human adenovirus type 7 vector.
Zheng et al., Wenzhou, China. In Immunol Lett, Jan 2016
We proved that cytokine TNF-╬▒, IL-6 and IL-10, surface molecule MHC class I and the CD86, antigen-processing machinery (APM) compounds ERp57, TAP-1, and TAP-2.
Revisiting the mechanistic basis of the French Paradox: Red wine inhibits the activity of protein disulfide isomerase in vitro.
Kennedy et al., United States. In Thromb Res, Jan 2016
The inhibition of PDI related thiol isomerases ERp5 and ERp57 was also assessed.
GPI Anchor Modification Machinery Deficiency is Responsible for the Formation of Pro-PrP in BxPC-3 and Increases Cancer Cell Motility.
Li et al., China. In J Biol Chem, Jan 2016
Expression of the individual gene, such as PGAP1, PIG-F, or PIG-C into BxPC-3 cells does not result in PI-PLC sensitivity of PrP.
LEDGF/p75 Overexpression Attenuates Oxidative Stress-Induced Necrosis and Upregulates the Oxidoreductase ERP57/PDIA3/GRP58 in Prostate Cancer.
Casiano et al., Loma Linda, United States. In Plos One, Dec 2015
Overexpression of LEDGF/p75 in PCa cells led to the upregulation of transcript and protein levels of the thiol-oxidoreductase ERp57 (also known as GRP58 and PDIA3), whereas its depletion led to ERp57 transcript downregulation.
A sweet code for glycoprotein folding.
Parodi et al., Buenos Aires, Argentina. In Febs Lett, Dec 2015
The control mechanism essentially involves four components, resident lectin-chaperones (calnexin and calreticulin) that recognize monoglucosylated polymannose protein-linked glycans, lectin-associated oxidoreductase acting on monoglucosylated glycoproteins (ERp57), a glucosyltransferase that creates monoglucosylated epitopes in protein-linked glycans (UGGT) and a glucosidase (GII) that removes the glucose units added by UGGT.
Plant phospholipase C family: Regulation and functional role in lipid signaling.
Pandey et al., New Delhi, India. In Cell Calcium, Aug 2015
Based on substrate specificity, plant PLC family is sub-divided into phosphatidylinositol-PLC (PI-PLC) and phosphatidylcholine-PLC (PC-PLC) groups.
Dual protein trafficking to secretory and non-secretory cell compartments: clear or double vision?
Christopher et al., Honolulu, United States. In Plant Sci, May 2015
Although classical PDIs possess an N-terminal signal peptide and a C-terminal ER retention signal, some also dual localize to secretory and non-secretory compartments, including mammalian PDI ERp57, Chlamydomonas reinhardtii PDI RB60, and A. thaliana AtPDI2.
Bacillus thuringiensis membrane-damaging toxins acting on mammalian cells.
Ghelardi et al., Pisa, Italy. In Fems Microbiol Lett, 2014
Similar to B. cereus, B. thuringiensis produces an array of virulence factors acting against mammalian cells, such as phosphatidylcholine- and phosphatidylinositol-specific phospholipase C (PC-PLC and PI-PLC), hemolysins, in particular hemolysin BL (HBL), and various enterotoxins.
Antrodia cinnamomea Inhibits Migration in Human Hepatocellular Carcinoma Cells: The Role of ERp57 and PGK-1.
Sheu et al., Taiwan. In Am J Chin Med, 2014
Evidences suggest that ERp57 and PGK-1 signaling lead to cancer cell proliferation and migration.
Role of the 1,25D3-MARRS receptor in the 1,25(OH)2D3-stimulated uptake of calcium and phosphate in intestinal cells.
Hintze et al., Logan, United States. In Steroids, 2012
Knockout of the Pdia3 protein in mice eliminates the rapid response to calcitriol in intestinal epithial cells.
Homozygous PLCB1 deletion associated with malignant migrating partial seizures in infancy.
Kothare et al., Boston, United States. In Epilepsia, 2012
case report - homozygous deletion associated with malignant migrating partial seizures in infancy
Serendipitous discovery of a novel protein signaling mechanism in heart failure.
Walker et al., Aurora, United States. In Biochem Biophys Res Commun, 2012
PDIA3 may play in the progression of heart failure.
A human homeotic transformation resulting from mutations in PLCB4 and GNAI3 causes auriculocondylar syndrome.
Cunningham et al., Seattle, United States. In Am J Hum Genet, 2012
The phenotypic variability of auriculocondylar syndrome suggests that mutations in this pathway, especially those affecting core signaling molecules such as PLCB4 and GNAI3, should be considered as potential candidates for other ear and jaw malformations.
Deletion of PLCB1 gene in schizophrenia-affected patients.
Polonia et al., Roma, Italy. In J Cell Mol Med, 2012
existence of a susceptibility locus on the short arm of chromosome 20 moved us to analyse PLCB1, the gene codifying for PI-PLC beta1 enzyme, which maps on 20p12
Mzb1 protein regulates calcium homeostasis, antibody secretion, and integrin activation in innate-like B cells.
Grosschedl et al., Freiburg, Germany. In Immunity, 2010
In addition to its interaction with the substrate-specific chaperone Grp94, Mzb1 augmented the function of the oxidoreductase ERp57 in favoring the expression of integrins in their activated conformation.
Insights into MHC class I peptide loading from the structure of the tapasin-ERp57 thiol oxidoreductase heterodimer.
Reinisch et al., New Haven, United States. In Immunity, 2009
the 2.6 A resolution structure of the tapasin-ERp57 core of the peptide-loading complex
More images that yet fresh images Beget.
Elliott, Southampton, United Kingdom. In Immunity, 2009
In this issue of Immunity, Dong et al. (2009) describe the protein crystal structure heterodimer of tapasin and ERp57, which helps visualize the function of these proteins in loading of peptide antigens onto MHC class I molecules as part of the peptide loading complex within the endoplasmic reticulum.
Crystal structure of squid rhodopsin.
Kouyama et al., Nagoya, Japan. In Nature, 2008
Invertebrate phototransduction uses an inositol-1,4,5-trisphosphate signalling cascade in which photoactivated rhodopsin stimulates a G(q)-type G protein, that is, a class of G protein that stimulates membrane-bound phospholipase Cbeta.
Simian Virus 40 depends on ER protein folding and quality control factors for entry into host cells.
Helenius et al., Z├╝rich, Switzerland. In Cell, 2007
We analyzed the effects of ER-associated processes and factors on infection and on isolated viruses and found that SV40 makes use of the thiol-disulfide oxidoreductases, ERp57 and PDI, as well as the retrotranslocation proteins Derlin-1 and Sel1L.
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