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Phosphoserine phosphatase

phosphoserine phosphatase, L-3-phosphoserine phosphatase, PSPH
The protein encoded by this gene belongs to a subfamily of the phosphotransferases. This encoded enzyme is responsible for the third and last step in L-serine formation. It catalyzes magnesium-dependent hydrolysis of L-phosphoserine and is also involved in an exchange reaction between L-serine and L-phosphoserine. Deficiency of this protein is thought to be linked to Williams syndrome. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, HAD, CAN, STEP, PSAT
Papers on phosphoserine phosphatase
Discovery of an intermolecular disulfide bond required for the thermostability of a heterodimeric protein from the thermophile Hydrogenobacter thermophilus.
Ishii et al., Tokyo, Japan. In Biosci Biotechnol Biochem, Feb 2016
Here, we report the first example of an intermolecular disulfide bond between heteromeric subunits of a novel-type phosphoserine phosphatase from a thermophilic bacterium Hydrogenobacter thermophilus, which contributes to the protein thermostability at the physiological temperature.
Microbial community dynamics in thermophilic undefined milk starter cultures.
Ricciardi et al., Potenza, Italy. In Int J Food Microbiol, Feb 2016
The microbial diversity was evaluated by 16S rRNA gene sequencing (V1-V3 regions), while the microdiversity of Streptococcus thermophilus populations was explored by using novel approach based on sequencing of partial amplicons of the phosphoserine phosphatase gene (serB).
A full genomic characterization of the development of a stable Small Colony Variant cell-type by a clinical Staphylococcus aureus strain.
Kidd et al., Adelaide, Australia. In Infect Genet Evol, Dec 2015
The genetic changes that had occurred in the stable SCV form were identified; most notably being in MgrA, a global regulator, and RsbU, a phosphoserine phosphatase within the regulatory pathway of the sigma factor SigB.
Novel Report of Phosphoserine Phosphatase Deficiency in an Adult with Myeloneuropathy and Limb Contractures.
Jayadev et al., Seattle, United States. In Jimd Rep, Dec 2015
Molecular analysis revealed compound heterozygous mutations in phosphoserine phosphatase (PSPH).
Relationship of proteomic variation and toxin synthesis in the dinoflagellate Alexandrium tamarense CI01 under phosphorus and inorganic nitrogen limitation.
Gu et al., Hong Kong, Hong Kong. In Ecotoxicology, Oct 2015
Based on the results of proteomics analysis, 7 proteins were discovered to be related to the PSTs biosynthesis of A. tamarense CI01, including S-adenosylhomocysteine hydrolase, ornithine cyclodeaminase, argininosuccinate synthase, methyluridine methyltransferase cystine ABC transporter, phosphoserine phosphatase, argininosuccinate synthase and acyl-CoA dehydrogenase, which corresponds to the metabolism of the methionine, cysteine, ornithine, arginine and proline.
Type 2 diabetes alters metabolic and transcriptional signatures of glucose and amino acid metabolism during exercise and recovery.
Weigert et al., Copenhagen, Denmark. In Diabetologia, Aug 2015
They also showed an exercise-induced compensatory regulation of genes involved in biosynthesis and metabolism of amino acids (PSPH, GATM, NOS1 and GLDC), which responded to differences in the amino acid profile (consistently lower plasma levels of glycine, cysteine and arginine).
Race-associated biological differences among Luminal A breast tumors.
Troester et al., Durham, United States. In Breast Cancer Res Treat, Jul 2015
Six genes (ACOX2, MUC1, CRYBB2, PSPH, SQLE, TYMS) were differentially expressed by race among Luminal A breast cancers and were associated with survival (HR <0.8, HR >1.25).
Lack of phosphoserine phosphatase activity alters pollen and tapetum development in Arabidopsis thaliana.
Ros et al., Burjassot, Spain. In Plant Sci, Jun 2015
Mutants of phosphoserine phosphatase (PSP), the enzyme that catalyses the last step of PPSB, are embryo-lethal.
cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions.
Zhang et al., Hefei, China. In Cell Res, Apr 2015
We further uncovered that phosphoserine phosphatase (PSPH), the final rate-limiting enzyme of the SSP pathway, is critical for cMyc-driven cancer progression both in vitro and in vivo, and importantly, aberrant expression of PSPH is highly correlated with mortality in hepatocellular carcinoma (HCC) patients, suggesting a potential causal relation between this cMyc-regulated enzyme, or SSP activation in general, and cancer development.
Establishing genomic/transcriptomic links between Alzheimer's disease and type 2 diabetes mellitus by meta-analysis approach.
Karim et al., Jiddah, Saudi Arabia. In Cns Neurol Disord Drug Targets, 2014
Significantly changed expression of "myeloid leukemia cell differentiation protein 1; RAS guanyl releasing protein 1; S100 calcium-binding protein A8; prostaglandin- endoperoxide synthase 2; parvalbumin; endoplasmic reticulum aminopeptidase 1; phosphoglycerate kinase 1; Eukaryotic translation initiation factor 3 subunit F; Interleukin-1 beta; tubulin, beta 2A; glycine receptor alpha 1 and ribosomal protein S24" genes were highly associated with T2DM, whereas "neuronal differentiation 6; G-protein coupled receptor 83; phosphoserine phosphatase; bobby sox homolog or HMG box -containing protein 2; Glutathione S-transferase theta 1; alpha-2-glycoprotein 1 zinc-binding; Heat shock 70kDa protein 1B; transportin 1, Acidic leucine-rich nuclear phosphoprotein 32 family member B; Nuclear factor of activated T-cells 5; inositol 1,4,5-trisphosphate 3-kinase B; prenylcysteine oxidase 1 like" were found to be strongly related with AD.
L-3-Phosphoserine phosphatase (PSPH) regulates cutaneous squamous cell carcinoma proliferation independent of L-serine biosynthesis.
Owens et al., New York City, United States. In J Dermatol Sci, 2011
status of PSPH in normal skin epidermis and skin tumors along with its sub-cellular localization in epidermal keratinocytes and its requirement for squamous cell carcinoma proliferation
[Modeling the transition state of enzyme-catalyzed phosphoryl transfer reaction using QM/MM method].
Sugita et al., Saitama, Japan. In Yakugaku Zasshi, 2010
We perform QM/MM simulations for the reversible phosphorylation of phosphoserine phosphatase (PSP), which belongs to one of the largest phosphotransferase families characterized to data.
Effect of carboxylate-binding mode on metal binding/selectivity and function in proteins.
Lim et al., Taipei, Taiwan. In Acc Chem Res, 2007
We reveal how the carboxylate-binding mode affects the binding affinity and selectivity of a metal ion as well as the function of a metalloprotein using Ca2+-binding proteins and enzymes (ribonuclease H1, phosphoserine phosphatase, and ribonucleotide reductase) as examples.
Treatment with amino acids in serine deficiency disorders.
de Koning, Utrecht, Netherlands. In J Inherit Metab Dis, 2006
At present two disorders have been reported: 3-phosphoglycerate dehydrogenase deficiency and 3-phosphoserine phosphatase deficiency.
[Possible mechanisms of A beta(1-40)- or A beta(1-42)-induced cell death and their rescue factors].
Heese et al., Takedamachi, Japan. In Nihon Yakurigaku Zasshi, 2004
By cDNA subtraction analysis in the cell death, the enhanced expression of L-phosphoserine phosphatase was found, but this was also abolished by IL-11.
How calcium inhibits the magnesium-dependent enzyme human phosphoserine phosphatase.
De Ranter et al., Leuven, Belgium. In Eur J Biochem, 2004
human phosphoserine phosphatase structure now shows a sevenfold coordinated Ca(2+) ion in the active site that might explain the inhibitory effect of Ca(2+) on the enzyme
Molecular basis for the local conformational rearrangement of human phosphoserine phosphatase.
Hwang et al., South Korea. In J Biol Chem, 2002
description of the first crystal structures of the HPSP in complexes with the competitive inhibitor 2-amino-3-phosphonopropionic a
Purification, crystallization and preliminary X-ray diffraction analysis of human phosphoserine phosphatase.
De Ranter et al., Leuven, Belgium. In Acta Crystallogr D Biol Crystallogr, 2002
purification, crystallization and preliminary X-ray diffraction analysis
Molecular biology of the plastidic phosphorylated serine biosynthetic pathway in Arabidopsis thaliana.
Saito et al., Chiba, Japan. In Amino Acids, 2000
The 3-phosphoglycerate pathway (phosphorylated pathway) involves three enzymes catalyzing three sequential reactions: 3-phosphoglycerate dehydrogenase (PGDH), 3-phosphoserine aminotransferase (PSAT) and 3-phosphoserine phosphatase (PSP).
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