Functional diversity of genes for the biosynthesis of paeoniflorin and its derivatives in Paeonia.
Beijing, China. In Int J Mol Sci, 2012
The correlation analysis of gene expression and active compound contents support the idea that hydroxymethylglutaryl-CoA synthase and phosphomevalonate kinase in the mevalonate pathway and 3-dehydroquinate dehydratase/shikimate dehydrogenase in shikimate biosynthesis are potentially closely related to the accumulation of paeoniflorin and benzoylpaeoniflorin.
Enzymes of the mevalonate pathway of isoprenoid biosynthesis.
Kansas City, United States. In Arch Biochem Biophys, 2011
While bacterial enzymes responsible for these three reactions share a common protein fold, animal enzymes differ in this respect as the recently reported structure of human phosphomevalonate kinase demonstrates.
Phosphomevalonate kinase is a cytosolic protein in humans.
Amsterdam, Netherlands. In J Lipid Res, 2004
found an exclusive cytosolic localization of both endogenously expressed PMVK(in human fibroblasts, human liver, and HEK293 cells) and overexpressed PMVK. No indication of a peroxisomal localization was obtained.