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Phospholipase D1, phosphatidylcholine-specific

phospholipase D, PLD1
This gene encodes a phosphatidylcholine-specific phospholipase which catalyzes the hydrolysis of phosphatidylcholine in order to yield phosphatidic acid and choline. The enzyme may play a role in signal transduction and subcellular trafficking. Alternative splicing results in multiple transcript variants with both catalytic and regulatory properties. [provided by RefSeq, Sep 2011] (from NCBI)
Top mentioned proteins: ACID, CAN, V1a, PLD2, HAD
Papers using phospholipase D antibodies
Inducible systemic RNA silencing in Caenorhabditis elegans
Gill Matthew S et al., In Nature, 2002
... Inactivation of N-acyl phosphatidylethanolamine phospholipase D reveals multiple mechanisms for the biosynthesis of endocannabinoids ...
Papers on phospholipase D
Gomez-Cambronero et al., Boston, United States. In Mol Cell Biol, Feb 2016
UNASSIGNED: We report a negative feedback loop between the signaling protein phospholipase D (PLD), phosphatidic acid (PA) and a specific set of miRNAs during nutrient starvation of breast cancer cells.
Recombinant murine toxin from Yersinia pestis shows high toxicity and β-adrenergic blocking activity in mice.
Wang et al., Hefei, China. In Microbes Infect, Feb 2016
UNASSIGNED: Yersinia pestis murine toxin (Ymt) encoded on pMT1 is a 61-kDa protein, a member of the phospholipase D superfamily, which is found in all the domains of life.
RhoA mediates the expression of acidic extracellular pH-induced matrix metalloproteinase-9 mRNA through phospholipase D1 in mouse metastatic B16-BL6 melanoma cells.
Kato et al., Kōriyama, Japan. In Int J Oncol, Feb 2016
The present study examined the contribution of small GTP-binding proteins to phospholipase D (PLD) activation of acidic pHe-induced matrix metalloproteinase-9 (MMP-9) production.
Fam83h null mice support a neomorphic mechanism for human ADHCAI.
Simmer et al., Montréal, Canada. In Mol Genet Genomic Med, Jan 2016
Pull-down studies determined that FAM83H dimerizes through its N-terminal phospholipase D-like (PLD-like) domain and identified potential FAM83H interacting proteins.
The transcription factors Slug (SNAI2) and Snail (SNAI1) regulate phospholipase D (PLD) promoter in opposite ways towards cancer cell invasion.
Gomez-Cambronero et al., Dayton, United States. In Mol Oncol, Jan 2016
We found that the activity of phospholipase D isoform 2 (PLD2) is highly increased in cancers with larger size and poor prognosis (MDA-MB-231 versus MCF-7 cells), so we determined if Snail or Slug were responsible for PLD2 gene transcription regulation.
Enzymatic synthesis and modification of structured phospholipids: recent advances in enzyme preparation and biocatalytic processes.
Kondo et al., Amagasaki, Japan. In Appl Microbiol Biotechnol, Oct 2015
Although the limited supply of phospholipases (e.g., phospholipase D) has thus far been an obstacle to the widespread use of enzymatic processing, recent advances in enzyme preparation have opened up various applications for PL modification.
Synaptic-like vesicles and candidate transduction channels in mechanosensory terminals.
Bewick, Aberdeen, United Kingdom. In J Anat, Aug 2015
The glutamate activates a highly unusual glutamate receptor linked to phospholipase D activation, which we have termed the PLD-mGluR.
On the Quest of Cellular Functions of PEA-15 and the Therapeutic Opportunities.
Wei, Jersey City, United States. In Pharmaceuticals (basel), 2014
Most notable interacting partners of PEA-15 include extracellular signal-regulated kinase 1 and 2 (ERK1/2) in the mitogen activated protein kinase (MAPK) pathway, the Fas-associated death domain (FADD) protein involving in the formation of the death-inducing signaling complex (DISC), and the phospholipase D1 (PLD1) affecting the insulin sensitivity.
Vps34 and PLD1 take center stage in nutrient signaling: their dual roles in regulating autophagy.
Yoon, Inch'ŏn, South Korea. In Cell Commun Signal, 2014
Recent studies have shown that phospholipase PLD1, a downstream regulator of Vps34, is also closely involved in both mTOR activation and autophagy.
Phospholipase D signaling pathways and phosphatidic acid as therapeutic targets in cancer.
Brown et al., Nashville, United States. In Pharmacol Rev, 2014
Phospholipase D is a ubiquitous class of enzymes that generates phosphatidic acid as an intracellular signaling species.
A Next generation PLD2 inhibitor with improved physiochemical properties and DMPK profile for translational in vivo
Lindsley et al., Bethesda, United States. In Unknown Journal, 2014
Further chemical optimization of our first generation phospholipase D2 (PLD2) probe (ML298) afforded ML395 (CID 73099363), a potent, >80-fold PLD2 selective allosteric inhibitor (cellular PLD1, IC50 >30,000 nM, cellular PLD2, IC50 = 360 nM).
Diverse type VI secretion phospholipases are functionally plastic antibacterial effectors.
Mougous et al., Seattle, United States. In Nature, 2013
Our analyses indicate that PldA of Pseudomonas aeruginosa, a eukaryotic-like phospholipase D, is a member of the type VI lipase effector superfamily and the founding substrate of the haemolysin co-regulated protein secretion island II T6SS (H2-T6SS).
Structure and function of Zucchini endoribonuclease in piRNA biogenesis.
Nureki et al., Tokyo, Japan. In Nature, 2012
Here we show that Zucchini (Zuc), a mitochondrial phospholipase D (PLD) superfamily member, is an endoribonuclease essential for primary piRNA biogenesis.
The B subunits of Shiga-like toxins induce regulated VWF secretion in a phospholipase D1-dependent manner.
Sadler et al., Saint Louis, United States. In Blood, 2012
Stx1B and Stx2B induce acute VWF secretion in a PLD1-dependent manner but do so by differentially modulating PKCalpha, RhoA, and ADP-ribosylation factor 6.
Overexpression of phospholipase D enhances Bcl-2 expression by activating STAT3 through independent activation of ERK and p38MAPK in HeLa cells.
Han et al., Seoul, South Korea. In Biochim Biophys Acta, 2012
PLD acts as an important regulator in Bcl-2 expression by activating STAT3 involving the phosphorylation of Ser727 through the PLA(2)/G(i)/ERK1/2, RhoA/ROCK/p38 MAPK, and Rac1/p38 MAPK pathways.
Phospholipase D and mTORC1: nutrients are what bring them together.
Thomas et al., Cincinnati, United States. In Sci Signal, 2012
Studies indicate that phospholipase D (PLD) as a mediator of nutrients to mTORC1.
Secondary, somatic mutations might promote cyst formation in patients with autosomal dominant polycystic liver disease.
Drenth et al., Nijmegen, Netherlands. In Gastroenterology, 2011
Polycystic liver disease is recessive at the cellular level, and loss of functional PRKCSH is an important step in cystogenesis.
Class III PI-3-kinase activates phospholipase D in an amino acid-sensing mTORC1 pathway.
Chen et al., Urbana, United States. In J Cell Biol, 2011
amino acids stimulate PLD1 translocation to the lysosomal region where mTORC1 activation occurs in an hVps34-dependent manner, and this translocation is necessary for mTORC1 activation
Sequential regulation of DOCK2 dynamics by two phospholipids during neutrophil chemotaxis.
Fukui et al., Fukuoka, Japan. In Science, 2009
However, subsequent accumulation of DOCK2 at the leading edge required phospholipase D-mediated synthesis of phosphatidic acid, which stabilized DOCK2 there by means of interaction with a polybasic amino acid cluster, resulting in increased local actin polymerization.
Regulation of conformer-specific activation of the integrin LFA-1 by a chemokine-triggered Rho signaling module.
Laudanna et al., Verona, Italy. In Nat Immunol, 2009
The Rho effectors PLD1 and PIP5KC were also critical to LFA-1 affinity modulation.
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