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Phospholipase A2, group IVA

phospholipase A2, cytosolic phospholipase A2, cPLA2, lysophospholipase
This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: PLA2, ACID, CAN, V1a, HAD
Papers using phospholipase A2 antibodies
Expression of secretory phospholipase A2 enzymes in lungs of humans with pneumonia and their potential prostaglandin-synthetic function in human lung-derived cells.
Uusitalo Hannu et al., In Molecular Vision, 2004
... Monoclonal antibodies against sPLA2-V and cPLA2 (sc-4-4B-3C, lot number E1704) and rabbit polyclonal antibodies against iPLA2 were purchased from Santa Cruz Biotechnology, Inc (Santa Cruz, CA) ...
Endothelin-1 (ET-1) Increases the Expression of Remodeling Genes in Vascular Smooth Muscle through Linked Calcium and cAMP Pathways
Knox Alan J. et al., In The Journal of Biological Chemistry, 2004
... inhibitor (cPLA2-I), AH6809, L161982, BQ123, BQ788, and RO-201724 were purchased from Calbiochem/Merck Chemical Ltd ...
Papers on phospholipase A2
Clinical usefulness of autoantibodies to M-type phospholipase A2 receptor (PLA2R) for monitoring disease activity in idiopathic membranous nephropathy (IMN).
Sinico et al., Milano, Italy. In Autoimmun Rev, Feb 2016
Autoantibodies to M-type phospholipase A2 receptor (PLA2R) are specific markers of idiopathic membranous nephropathy (IMN).
The onset of lipid peroxidation in rheumatoid arthritis: consequences and monitoring.
Skrzydlewska et al., Białystok, Poland. In Free Radic Res, Feb 2016
Cytosolic phospholipase A2 (cPLA2), platelet-activating factor acetylhydrolase (PAF-AH) and glutathione peroxidase (GSH-Px) activities and vitamin E levels were also determined.
Lipoprotein-associated phospholipase A2 is related to risk of subclinical atherosclerosis but is not supported by Mendelian randomization analysis in a general Japanese population.
ACCESS and SESSA Research Groups et al., Ōtsu, Japan. In Atherosclerosis, Jan 2016
OBJECTIVE: Lipoprotein-associated phospholipase A2 (Lp-PLA2) is an enzyme predominantly bound to low-density lipoprotein (LDL).
Neuroprotective effects of bee venom phospholipase A2 in the 3xTg AD mouse model of Alzheimer's disease.
Bae et al., Seoul, South Korea. In J Neuroinflammation, Dec 2015
Previously, we found the population of Treg cells was significantly increased by bee venom phospholipase A2 (bvPLA2) treatment in vivo and in vitro.
Screening for coronary artery disease in asymptomatic individuals: Why and how?
Ducrocq et al., Paris, France. In Arch Cardiovasc Dis, Dec 2015
Apart from established risk scores based on traditional risk factors such as the Framingham or SCORE risk scores, new biomarkers and imaging methods have emerged (high-sensitivity C-reactive protein, lipoprotein-associated phospholipase A2 and secretory phospholipase A2, coronary artery calcium score, carotid intima-media thickness and ankle-brachial index).
Replacing carbohydrate with protein and fat in prediabetes or type-2 diabetes: greater effect on metabolites in PBMC than plasma.
Lee et al., Seoul, South Korea. In Nutr Metab (lond), Dec 2015
This study examined whether reductions in PBMCs and plasma lipoprotein-associated phospholipase A2 (Lp-PLA2) activities induced by dietary intervention affected the overall metabolic profiles of PBMC and plasma.
Membranous nephropathy: A fairy tale for immunopathologists, nephrologists and patients.
Debiec et al., Paris, France. In Mol Immunol, Nov 2015
It shows how experimental models developed more than 30 years ago have led to the identification of several human antigens including neutral endopeptidase in the neonate, phospholipase A2 receptor, and thrombospondin 1 domain 7A in the adult, and cationic bovine serum albumin in children.
Comparison of Serum LP-PLA2 Level and some Nutritional Factors between Well-Controlled and Poorly-Controlled Diabetic Patients.
Jalali et al., Tehrān, Iran. In Acta Med Iran, Nov 2015
Lipoprotein-associated phospholipase A2 (Lp-PLA2) is produced by inflammatory cells, bound to LDL and other lipoproteins, and hydrolyzes oxidized phospholipids in LDL.
Pathophysiological advances in membranous nephropathy: time for a shift in patient's care.
Debiec et al., Paris, France. In Lancet, Jun 2015
In 2002, podocyte neutral endopeptidase was identified as an antigenic target of circulating antibodies in alloimmune neonatal nephropathy, and in 2009, podocyte phospholipase A2 receptor (PLA2R) was reported as an antigenic target in autoimmune adult membranous nephropathy.
Thrombospondin type-1 domain-containing 7A in idiopathic membranous nephropathy.
Lambeau et al., Antibes, France. In N Engl J Med, 2015
In approximately 70% of patients, it is associated with autoantibodies against the phospholipase A2 receptor 1 (PLA2R1).
Antiphospholipase A2 Receptor Autoantibodies: A Step Forward in the Management of Primary Membranous Nephropathy.
Mircescu et al., Bucureşti, Romania. In Biomed Res Int, 2014
Since the identification of PLA2R (M-type phospholipase A2 receptor) as the first human antigenic target in primary membranous nephropathy (MN), perpetual progress has been made in understanding the pathogenesis of this disease.
Modulation of Potassium Channel Activity in the Balance of ROS and ATP Production by Durum Wheat Mitochondria-An Amazing Defense Tool Against Hyperosmotic Stress.
Pastore et al., Foggia, Italy. In Front Plant Sci, 2014
In particular, under moderate hyperosmotic stress (mannitol or NaCl), PmitoKATP was found to be activated by ROS, so inhibiting further large-scale ROS production according to a feedback mechanism; moreover, a stress-activated phospholipase A2 may generate FFAs, further activating the channel.
Effect of darapladib on major coronary events after an acute coronary syndrome: the SOLID-TIMI 52 randomized clinical trial.
Steen et al., Auckland, New Zealand. In Jama, 2014
IMPORTANCE: Lipoprotein-associated phospholipase A2 (Lp-PLA2) has been hypothesized to be involved in atherogenesis through pathways related to inflammation.
A mitochondrial pathway for biosynthesis of lipid mediators.
Kagan et al., Pittsburgh, United States. In Nat Chem, 2014
We show that a number of oxygenated CL species undergo phospholipase A2-catalysed hydrolysis and thus generate multiple oxygenated fatty acids, including well-known lipid mediators.
Darapladib for preventing ischemic events in stable coronary heart disease.
Wallentin et al., In N Engl J Med, 2014
BACKGROUND: Elevated lipoprotein-associated phospholipase A2 activity promotes the development of vulnerable atherosclerotic plaques, and elevated plasma levels of this enzyme are associated with an increased risk of coronary events.
Role of cytosolic calcium-dependent phospholipase A2 in Alzheimer's disease pathogenesis.
Colucci-D'Amato et al., Caserta, Italy. In Mol Neurobiol, 2012
The molecular and biological evidence of the involvement of cPLA2s in the pathogenesis of Alzheimer's disease, is reviewed.
Effects of the inhibition of cytosolic phospholipase A(2)α in non-small cell lung cancer cells.
Gunasekaran et al., Coimbatore, India. In J Cancer Res Clin Oncol, 2012
Immunohistochemical expressions of cPLA(2)alpha in 23 species of human non-small lung cancer and 5 species of human normal lung to assess their clinicopathological relevance.
A VE-cadherin-PAR3-α-catenin complex regulates the Golgi localization and activity of cytosolic phospholipase A(2)α in endothelial cells.
Walker et al., Leeds, United Kingdom. In Mol Biol Cell, 2012
A VE-cadherin-PAR3-alpha-catenin complex regulates the Golgi localization and activity of cytosolic phospholipase A(2)alpha in endothelial cells.
cPLA2α and EHD1 interact and regulate the vesiculation of cholesterol-rich, GPI-anchored, protein-containing endosomes.
Naslavsky et al., Omaha, United States. In Mol Biol Cell, 2012
the lipid modifier cPLA2alpha and EHD1 are involved in the vesiculation of CD59-containing endosomes
Association of PLA2G4A with myocardial infarction is modulated by dietary PUFAs.
Allayee et al., Los Angeles, United States. In Am J Clin Nutr, 2012
genetic association studies in populations in Costa Rica: An SNP in PLA2G4A (rs12746200) is associated with myocardial infarction; this association is modulated by dietary factors (i.e., omega-6 fatty acid intake).
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