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Phosphoglycerate kinase 2

Phosphoglycerate Kinase, PGK2
This gene is intronless, arose via retrotransposition of the phosphoglycerate kinase 1 gene, and is expressed specifically in the testis. Initially assumed to be a pseudogene, the encoded protein is actually a functional phosphoglycerate kinase that catalyzes the reversible conversion of 1,3-bisphosphoglycerate to 3-phosphoglycerate, during the Embden-Meyerhof-Parnas pathway of glycolysis, in the later stages of spermatogenesis.[provided by RefSeq, May 2010] (from NCBI)
Top mentioned proteins: PKG, CAN, ACID, Phosphoglycerate Kinase, HAD
Papers using Phosphoglycerate Kinase antibodies
NAD+ depletion is necessary and sufficient for poly(ADP-ribose) polymerase-1-mediated neuronal death
Strack Stefan, In PLoS ONE, 2009
... crossed to transgenic mice carrying the SB11 transposase under the control of a 1.4-kb testis-specific human PGK2 promoter [20] After mobilization of the gene trap in the double transgenic male gametes and crossing ...
Papers on Phosphoglycerate Kinase
Evaluation of two novel barcodes for species recognition of opportunistic pathogens in Fusarium.
Levesque et al., Utrecht, Netherlands. In Fungal Biol, Feb 2016
We demonstrate the potential of two recently discovered DNA barcode loci, topoisomerase I (TOP1) and phosphoglycerate kinase (PGK), in combination with other routinely used markers such as TEF1, in an analysis of 144 Fusarium strains belonging to 52 species.
Characteristics of testis-specific phosphoglycerate kinase 2 and its association with human sperm quality.
Wang et al., Yantai, China. In Hum Reprod, Feb 2016
STUDY QUESTION: Is there an association between the expression of phosphoglycerate kinase (PGK) 2 in spermatozoa and sperm quality in both elderly men and young asthenozoospermia patients?
31P magnetization transfer measurements of Pi->ATP flux in exercising human muscle.
Kemp et al., Liverpool, United Kingdom. In J Appl Physiol, Feb 2016
The coupled reactions catalyzed by the glycolytic enzymes glyceraldehyde 3-phosphate dehydrogenase (GAPDH) and phosphoglycerate kinase (PGK) have been shown to catalyze measurable exchange between ATP and Pi in some systems and have been suggested to be responsible for this surplus flux.
Cytoskeleton deregulation and impairment in amino acids and energy metabolism in early atherosclerosis at aortic tissue with reflection in plasma.
Alvarez-Llamas et al., Madrid, Spain. In Biochim Biophys Acta, Jan 2016
A molecular response to oxidative stress is evidenced, involving changes in the glucose metabolism enzymes pyruvate kinase (PKM) and phosphoglycerate kinase (PGK), and pyruvate.
Down-Regulated Phosphoglycerate Kinase 1 Expression Is Associated With Poor Prognosis in Patients With Gallbladder Cancer.
Liu et al., Shanghai, China. In Medicine (baltimore), Dec 2015
To evaluate prognostic significance of phosphoglycerate kinase 1 (PGK1) protein expression in patients with gallbladder cancer (GBC).Ninety-five patients who underwent surgical resection for GBC between January 2004 and December 2010 were enrolled.
Establishing genomic/transcriptomic links between Alzheimer's disease and type 2 diabetes mellitus by meta-analysis approach.
Karim et al., Jiddah, Saudi Arabia. In Cns Neurol Disord Drug Targets, 2014
Significantly changed expression of "myeloid leukemia cell differentiation protein 1; RAS guanyl releasing protein 1; S100 calcium-binding protein A8; prostaglandin- endoperoxide synthase 2; parvalbumin; endoplasmic reticulum aminopeptidase 1; phosphoglycerate kinase 1; Eukaryotic translation initiation factor 3 subunit F; Interleukin-1 beta; tubulin, beta 2A; glycine receptor alpha 1 and ribosomal protein S24" genes were highly associated with T2DM, whereas "neuronal differentiation 6; G-protein coupled receptor 83; phosphoserine phosphatase; bobby sox homolog or HMG box -containing protein 2; Glutathione S-transferase theta 1; alpha-2-glycoprotein 1 zinc-binding; Heat shock 70kDa protein 1B; transportin 1, Acidic leucine-rich nuclear phosphoprotein 32 family member B; Nuclear factor of activated T-cells 5; inositol 1,4,5-trisphosphate 3-kinase B; prenylcysteine oxidase 1 like" were found to be strongly related with AD.
Conformational dynamics in phosphoglycerate kinase, an open and shut case?
Bowler, Grenoble, France. In Febs Lett, 2013
Phosphoglycerate kinase (PGK) undergoes large domain movements in order to catalyse the production of ATP.
Cryptic peroxisomal targeting via alternative splicing and stop codon read-through in fungi.
Bölker et al., Marburg an der Lahn, Germany. In Nature, 2012
Here we show that in numerous fungal species, several core enzymes of glycolysis, including glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and 3-phosphoglycerate kinase (PGK), reside in both the cytoplasm and peroxisomes.
Neuron-glia interactions in glutamatergic neurotransmission: roles of oxidative and glycolytic adenosine triphosphate as energy source.
Waagepetersen et al., Copenhagen, Denmark. In J Neurosci Res, 2011
Western blotting of glyceraldehyde-3-P dehydrogenase (GAPDH) and phosphoglycerate kinase (PGK) was performed to determine whether these enzymes are associated with the cell membrane.
Progress and problems in muscle glycogenoses.
Spiegel et al., New York City, United States. In Acta Myol, 2011
We observed an interesting association between phosphoglycerate kinase deficiency (GSD IX) and juvenile Parkinsonism, which is probably causal rather than casual.
Protein folding stability and dynamics imaged in a living cell.
Gruebele et al., Urbana, United States. In Nat Methods, 2010
We demonstrated the method by measuring the reversible fast folding kinetics as well as folding thermodynamics of a fluorescence resonance energy transfer (FRET) probe-labeled phosphoglycerate kinase construct in two human cell lines.
A diagnostic algorithm for metabolic myopathies.
Hirano et al., New York City, United States. In Curr Neurol Neurosci Rep, 2010
CK-creatine kinase; COX-cytochrome c oxidase; CPT-carnitine palmitoyl transferase; cyt b-cytochrome b; mtDNA-mitochondrial DNA; nDNA-nuclear DNA; PFK-phosphofructokinase; PGAM-phosphoglycerate mutase; PGK-phosphoglycerate kinase; PPL-myophosphorylase; RRF-ragged red fibers; TFP-trifunctional protein deficiency; VLCAD-very long-chain acyl-coenzyme A dehydrogenase.
Phosphoglycerate kinase acts in tumour angiogenesis as a disulphide reductase.
Hogg et al., Sydney, Australia. In Nature, 2001
Here we show that the plasmin reductase isolated from conditioned medium of fibrosarcoma cells is the glycolytic enzyme phosphoglycerate kinase.
Ligation-mediated PCR for quantitative in vivo footprinting.
Flanagan et al., Duarte, United States. In Nat Biotechnol, 2000
We showed that the technique could be used for sensitive and reproducible in vivo photofootprinting of the human phosphoglycerate kinase 1 (PGK1) promoter, as well as providing good Maxam-Gilbert sequence information.
Neuron-restrictive silencer elements mediate neuron specificity of adenoviral gene expression.
Barkats et al., Paris, France. In Nat Biotechnol, 1999
By generating adenoviral constructs in which NRSE sequences were placed upstream from the ubiquitous phosphoglycerate kinase promoter, the specificity of expression of a luciferase reporter gene was tested in both cell lines and primary cultures.
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