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Phosphogluconate dehydrogenase

Phosphogluconate Dehydrogenase, 6-phosphogluconate dehydrogenase, SERA
6-phosphogluconate dehydrogenase is the second dehydrogenase in the pentose phosphate shunt. Deficiency of this enzyme is generally asymptomatic, and the inheritance of this disorder is autosomal dominant. Hemolysis results from combined deficiency of 6-phosphogluconate dehydrogenase and 6-phosphogluconolactonase suggesting a synergism of the two enzymopathies. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, HAD, CAN, glucose-6-phosphate dehydrogenase, Phosphoglucomutase
Papers on Phosphogluconate Dehydrogenase
Purification and biochemical characterization of glucose 6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase and glutathione reductase from rat lung and inhibition effects of some antibiotics.
New
Ciftci et al., Bingöl, Turkey. In J Enzyme Inhib Med Chem, Feb 2016
UNASSIGNED: G6PD, 6PGD and GR have been purified separately in the single step from rat lung using 2', 5'-ADP Sepharose 4B affinity chromatography.
Improved xylitol production from D-arabitol by enhancing the coenzyme regeneration efficiency of the pentose phosphate pathway in Gluconobacter oxydans.
New
Feng et al., In J Agric Food Chem, Feb 2016
Glucose-6-phosphate dehydrogenase (G6PDH) and 6-phosphogluconate dehydrogenase (6PGDH) were overexpressed in G. oxydans.
Effect and mechanism of waterborne prolonged Zn exposure influencing hepatic lipid metabolism in javelin goby Synechogobius hasta.
New
Pan et al., Wuhan, China. In J Appl Toxicol, Dec 2015
Zn exposure increased Zn content, declined hepatic lipid content and reduced viscerosomatic and hepatosomatic indices and lipogenic enzyme activities, including 6-phosphogluconate dehydrogenase (6PGD), glucose-6-phosphate dehydrogenase (G6PD), malic enzyme (ME) and fatty acid synthase (FAS).
6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.
Review
New
Impact
Chen et al., Atlanta, United States. In Nat Cell Biol, Nov 2015
The oxidative pentose phosphate pathway (PPP) contributes to tumour growth, but the precise contribution of 6-phosphogluconate dehydrogenase (6PGD), the third enzyme in this pathway, to tumorigenesis remains unclear.
[GLUCOSE METABOLISM IN SURFACTANTS PRODUCER NOCARDIA VACCINII IMV B-7405].
New
Beregova et al., In Mikrobiol Z, Sep 2015
6-Phosphogluconate was involved into pentose phosphate cycle by constitutive NADP(+)-dependent 6-phosphogluconate dehydrogenase (activity 357 ± 17 nmol x min(-1) x mg(-1) of protein).
Quantifying NAD(P)H production in the upper Entner-Doudoroff pathway from Pseudomonas putida KT2440.
Gomez et al., São Paulo, Brazil. In Febs Open Bio, 2014
Additionally, we obtained data suggesting that the reaction catalyzed by the 6-phosphogluconate dehydrogenase is active during growth on glucose, and it also produces NADH.
Metabolic engineering of Mortierella alpina for arachidonic acid production with glycerol as carbon source.
Chen et al., Wuxi, China. In Microb Cell Fact, 2014
Overexpression of malic enzyme (ME1) but not glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase or isocitrate dehydrogenase significantly increased fatty acid content when glycerol was used as carbon source.
The regulation of the oxidative phase of the pentose phosphate pathway: new answers to old problems.
Review
Ramos-Martínez et al., Lugo, Spain. In Iubmb Life, 2014
Theoretically, in anabolic situations, the increase of gene expression of G6PD and 6-phosphogluconate dehydrogenase can induce a rise in the production of NADPH, which would cause the immediate inhibition of the enzyme and a drastic flow reduction.
Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth.
Impact
Chen et al., Atlanta, United States. In Cancer Cell, 2012
3-PG binds to and inhibits 6-phosphogluconate dehydrogenase in the oxidative pentose phosphate pathway (PPP), while 2-PG activates 3-phosphoglycerate dehydrogenase to provide feedback control of 3-PG levels.
Glycolytic cancer cells lacking 6-phosphogluconate dehydrogenase metabolize glucose to induce senescence.
GeneRIF
Chan et al., Boston, United States. In Febs Lett, 2012
Glycolytic cancer cells lacking 6-phosphogluconate dehydrogenase metabolize glucose to induce senescence
Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.
GeneRIF
Bahn et al., Cambridge, United Kingdom. In J Proteome Res, 2012
A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration.
Niacin and biosynthesis of PGD₂by platelet COX-1 in mice and humans.
GeneRIF
FitzGerald et al., Philadelphia, United States. In J Clin Invest, 2012
platelet DP1 is not present in mice. Despite this, DP1 deletion in mice augmented aneurysm formation and the hypertensive response to Ang II and accelerated atherogenesis and thrombogenesis.
PHGDH amplification and altered glucose metabolism in human melanoma.
GeneRIF
Locasale et al., Boston, United States. In Pigment Cell Melanoma Res, 2011
The potential mechanisms by which PHGDH promotes cancer are discussed.
Novel strategies to improve DNA vaccine immunogenicity.
Review
Ishii et al., Ōsaka, Japan. In Curr Gene Ther, 2011
Importantly, incorporation of TBK1 into a DNA vaccine was found to enhance the antigen-specific humoral immune responses targeting the Plasmodium falciparum serine repeat antigen (SERA), a candidate vaccine antigen expressed in the blood-stages of human malaria parasites.
Distinct roles of prostaglandin D2 receptors in chronic skin inflammation.
GeneRIF
Yokozeki et al., Tokyo, Japan. In Mol Immunol, 2011
The present study demonstrates that functional roles of PGD2 and its receptors appear to depend on the nature of the inflammation in chronic skin inflammation, chronic contact hypersensitivity and IgE-mediated chronic allergic skin inflammation
Falcipains and other cysteine proteases of malaria parasites.
Review
Rosenthal, San Francisco, United States. In Adv Exp Med Biol, 2010
Gene disruption studies suggested that SERA-5 and SERA-6 are essential.
[Malaria vaccine].
Review
Horii, Ōsaka, Japan. In Nihon Rinsho, 2008
Immunoepidemiological data underscores the uniqueness of SERA vs. other vaccine candidate, showing a semi-perfect correlation of the naturally induced antibody response to SE36 protein with increased protective immunity in adults and children.
Subcellular discharge of a serine protease mediates release of invasive malaria parasites from host erythrocytes.
Impact
Blackman et al., London, United Kingdom. In Cell, 2008
There, PfSUB1 mediates the proteolytic maturation of at least two essential members of another enzyme family called SERA.
Boron in plants: a biochemical role.
Impact
Aronoff et al., In Science, 1967
This effect results from the association of borate with 6-phosphogluconic acid, forming a virtual substrate that inhibits the action of 6-phosphogluconate dehydrogenase.
X-linked 6-phosphogluconate dehydrogenase in drosophila: subunit associations.
Impact
Childs et al., In Science, 1966
6-Phosphogluconate dehydrogenase (PGD) subunits have been dissociated and reassociated in vitro.
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