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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Phosphoglucomutase 1

Phosphoglucomutase, PGM1, NG2
The protein encoded by this gene is an isozyme of phosphoglucomutase (PGM) and belongs to the phosphohexose mutase family. There are several PGM isozymes, which are encoded by different genes and catalyze the transfer of phosphate between the 1 and 6 positions of glucose. In most cell types, this PGM isozyme is predominant, representing about 90% of total PGM activity. In red cells, PGM2 is a major isozyme. This gene is highly polymorphic. Mutations in this gene cause glycogen storage disease type 14. Alternativley spliced transcript variants encoding different isoforms have been identified in this gene.[provided by RefSeq, Mar 2010] (from NCBI)
Top mentioned proteins: CAN, Glial Fibrillary Acidic Protein, HAD, V1a, nestin
Papers using Phosphoglucomutase antibodies
A network of PDZ-containing proteins regulates T cell polarity and morphology during migration and immunological synapse formation
Schwamborn Jens C et al., In BMC Neuroscience, 2004
... anti-GFAP (mouse, Millipore), anti-Mash1 (mouse, BD Bioscience), anti-TuJ1 (mouse, Covance), anti- GST-π (mouse, BD Bioscience), anti-NG2 (mouse, Millipore), anti-PDGFRα (rat, Millipore) and F4/80 (rat, Abcam).
Neuronal ubiquitin and neurofilament expression in different lysosomal storage disorders
Elleder Milan et al., In Acta Neuropathologica, 1991
... CD68 (PGM1)DAKO, Copenhagen, Denmark ...
Papers on Phosphoglucomutase
Ecotropic Murine Leukemia Virus Infection of Glial Progenitors Interferes with Oligodendrocyte Differentiation: Implications for Neurovirulence.
Lynch et al., Kent, United States. In J Virol, Feb 2016
While the etiologic mechanisms and the glial subtypes involved remain unresolved, NG2 glia infection was recently observed to correlate spatially and temporally with altered neuronal physiology and spongiogenesis.
Genetic and biochemical characterization of genes involved in hyaluronic acid synthesis in Streptococcus zooepidemicus.
Liu et al., Tianjin, China. In Appl Microbiol Biotechnol, Feb 2016
Of the two phosphoglucomutase paralogues, pgm1 and pgm2, the former is responsible for around 10 % of activity, while the latter is responsible for 90 %.
An NF-κB - EphrinA5-Dependent Communication between NG2(+) Interstitial Cells and Myoblasts Promotes Muscle Growth in Neonates.
Guttridge et al., Columbus, United States. In Dev Cell, Feb 2016
Here, we provide insight into this process by revealing a unique NF-κB-dependent communication between NG2(+) interstitial cells and myoblasts.
Fetal liver hematopoietic stem cell niches associate with portal vessels.
Frenette et al., United States. In Science, Feb 2016
We show that Nestin(+)NG2(+) pericytes associate with portal vessels, forming a niche promoting HSC expansion.
Chronic stress regulates NG2(+) cell maturation and myelination in the prefrontal cortex through induction of death receptor 6.
Li et al., Nanchang, China. In Exp Neurol, Feb 2016
However, whether and how chronic stress regulates the maturation of NG2-expressing oligodendrocyte precursor cells (NG2(+) cells) and the importance of these changes remained unknown.
Phosphoglucomutase-1 deficiency: Intrafamilial clinical variability and common secondary adrenal insufficiency.
Hershkovitz et al., Beersheba, Israel. In Am J Med Genet A, Dec 2015
Phosphoglucomutase 1 (PGM1, EC plays a critical role in glucose homeostasis and is also essential for protein N-glycosylation.
Oligodendrocyte progenitor programming and reprogramming: Toward myelin regeneration.
Richard Lu et al., Cincinnati, United States. In Brain Res, Dec 2015
This article is part of a Special Issue entitled SI:NG2-glia(Invited only).
NG2 Proteoglycan-dependent contributions of pericytes and macrophages to brain tumor vascularization and progression.
Yotsumoto et al., Taejŏn, South Korea. In Microcirculation, Nov 2015
UNASSIGNED: The NG2 proteoglycan promotes tumor growth as a component of both tumor and stromal cells.
The heterogeneous nature of NG2-glia.
Dimou et al., München, Germany. In Brain Res, Oct 2015
UNASSIGNED: In the central nervous system, NG2-glia are the cells responsible for the generation of mature oligodendrocytes during development and adulthood.
Local production of astrocytes in the cerebral cortex.
Jia et al., Dallas, United States. In Neuroscience, Oct 2015
Astrocytes in the cerebral cortex are reportedly generated from four sources, namely radial glia, progenitors in the subventricular zone (SVZ progenitors), locally proliferating glia, and NG2 glia; it remains an open question, however, as to what extent these four cell types contribute to the substantial increase in astrocytes that occurs postnatally in the cerebral cortex.
Lineage, fate, and fate potential of NG2-glia.
Patel et al., United States. In Brain Res, Sep 2015
UNASSIGNED: NG2 cells represent a fourth major glial cell population in the mammalian central nervous system (CNS).
Acute myelogenous leukemia-induced sympathetic neuropathy promotes malignancy in an altered hematopoietic stem cell niche.
Frenette et al., United States. In Cell Stem Cell, 2014
Development of AML disrupts SNS nerves and the quiescence of Nestin(+) niche cells, leading to an expansion of phenotypic MSPCs primed for osteoblastic differentiation at the expense of HSC-maintaining NG2(+) periarteriolar niche cells.
Leptin-receptor-expressing mesenchymal stromal cells represent the main source of bone formed by adult bone marrow.
Morrison et al., Dallas, United States. In Cell Stem Cell, 2014
LepR(+) cells were Scf-GFP(+), Cxcl12-DsRed(high), and Nestin-GFP(low), markers which also highly enriched CFU-Fs, but negative for Nestin-CreER and NG2-CreER, markers which were unlikely to be found in CFU-Fs.
Glial cells as progenitors and stem cells: new roles in the healthy and diseased brain.
Götz et al., München, Germany. In Physiol Rev, 2014
We then proceed to the adult stage and discuss the glial cells that continue to act as NSCs across vertebrates and others that are more lineage-restricted, such as the adult NG2-glia, the most frequent progenitor type in the adult mammalian brain, that remain within the oligodendrocyte lineage.
Secretion of shh by a neurovascular bundle niche supports mesenchymal stem cell homeostasis in the adult mouse incisor.
Chai et al., Los Angeles, United States. In Cell Stem Cell, 2014
In contrast, NG2(+) pericytes represent an MSC subpopulation derived from Gli1+ cells; they express classical MSC markers and contribute little to homeostasis but are actively involved in injury repair.
Estradiol protects dermal hyaluronan/versican matrix during photoaging by release of epidermal growth factor from keratinocytes.
Fischer et al., Düsseldorf, Germany. In J Biol Chem, 2012
E(2) treatment increases the amount of dermal HA and versican V2 via paracrine release of EGF, which may be implicated in the pro-proliferative and anti-inflammatory effects of E(2) during photoaging.
Altered expression of sialylated glycoproteins in breast cancer using hydrazide chemistry and mass spectrometry.
Zhang et al., Baltimore, United States. In Mol Cell Proteomics, 2012
Tissue microarray analysis revealed that epithelial expression of versican had significant relations to lymph node metastasis and pathological stages of breast cancer
Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.
Bahn et al., Cambridge, United Kingdom. In J Proteome Res, 2012
A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration.
RhoGDI2 suppresses lung metastasis in mice by reducing tumor versican expression and macrophage infiltration.
Theodorescu et al., Charlottesville, United States. In J Clin Invest, 2012
RhoGDI2 suppresses lung metastasis in mouse models by reducing the expression of isoforms V1 and V3 of the proteoglycan versican, which is require for lung metastasis. High versican levels portended poor prognosis in patients with bladder cancer.
Interleukin-11 promotes the progress of gastric carcinoma via abnormally expressed versican.
Jiao et al., Shanghai, China. In Int J Biol Sci, 2011
The major isoforms expressed by gastric carcinoma & gastric cell lines were V0 & V1. V1 was higher in gastric carcinoma. Abnormally expressed versican & its isoforms participate in the progress of gastric carcinoma triggered by IL-11.
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