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Phosphoenolpyruvate carboxykinase 1

phosphoenolpyruvate carboxykinase, PCK1
This gene is a main control point for the regulation of gluconeogenesis. The cytosolic enzyme encoded by this gene, along with GTP, catalyzes the formation of phosphoenolpyruvate from oxaloacetate, with the release of carbon dioxide and GDP. The expression of this gene can be regulated by insulin, glucocorticoids, glucagon, cAMP, and diet. Defects in this gene are a cause of cytosolic phosphoenolpyruvate carboxykinase deficiency. A mitochondrial isozyme of the encoded protein also has been characterized. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Insulin, ACID, V1a, HAD, CAN
Papers using phosphoenolpyruvate carboxykinase antibodies
LYVE-1, the lymphatic system and tumor lymphangiogenesis
Supplier
Lahm Harald et al., In Journal of Carcinogenesis, 2000
... Female NMRI mice, overexpressing human IGF-II under the control of the rat phosphoenolpyruvate carboxykinase (PEPCK) promoter in several tissues including colon [24] and their non-transgenic female NMRI littermates were ...
Papers on phosphoenolpyruvate carboxykinase
Beneficial effect of farnesoid X receptor activation on metabolism in a diabetic rat model.
New
Zeng et al., Wuhan, China. In Mol Med Report, Feb 2016
Reverse transcription‑quantitative polymerase chain reaction and western blotting assays were performed to determine the RNA and protein expression of FXR, phosphoenolpyruvate carboxykinase, G6Pase, proliferator‑activated receptor‑γ coactivator‑1 and short heterodimer partner in rat liver tissue.
PCK1 is negatively regulated by bta-miR-26a, and a single-nucleotide polymorphism in the 3' untranslated region is involved in semen quality and longevity of Holstein bulls.
New
Zhong et al., Jinan, China. In Mol Reprod Dev, Feb 2016
UNASSIGNED: Phosphoenolpyruvate carboxykinase 1 (PCK1) is a multi-functional enzyme that plays important roles in physiological processes, including reproduction.
Antidiabetic effect of total saponins from Polygonatum kingianum in streptozotocin-induced daibetic rats.
New
Yu et al., Kunming, China. In J Ethnopharmacol, Jan 2016
Expressions of adenosine monophosphate activated protein kinase (AMPK), phosphoenolpyruvate carboxykinase (PEPCK), the relative transcript level of glucose kinase and glucose-6-phosphatase (GK/G6P) in the liver were investigated.
The effect of insulin on plasma glucose concentrations, expression of hepatic glucose transporters and key gluconeogenic enzymes during the perinatal period in broiler chickens.
New
Everaert et al., Leuven, Belgium. In Gen Comp Endocrinol, Jan 2016
However, little is known about the response of insulin on plasma glucose concentrations and mRNA abundance of hepatic glucose transporters 1, 2, 3, 8, 9 and 12 (GLUT 1, 2, 3, 8, 9 and 12) and three regulatory enzymes of the gluconeogenesis, phosphoenolpyruvate carboxykinase 1 and 2 (PCK 1 and 2) or fructose-1,6-biphosphatase 1 (FBP1) in chicks during the perinatal period.
The odd-carbon medium-chain fatty triglyceride triheptanoin does not reduce hepatic steatosis.
New
Koehler et al., Maastricht, Netherlands. In Clin Nutr, Jan 2016
It also induced pyruvate cycling through an increased hepatic PCK1 protein concentration and it increased thermogenesis reflected by an increased Ucp2 mRNA content.
Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses.
New
Impact
Kaech et al., New Haven, United States. In Cell, Oct 2015
Tumor-specific CD4 and CD8 T cells could be metabolically reprogrammed by increasing PEP production through overexpression of phosphoenolpyruvate carboxykinase 1 (PCK1), which bolstered effector functions.
pH-responsive, gluconeogenic renal epithelial LLC-PK1-FBPase+cells: a versatile in vitro model to study renal proximal tubule metabolism and function.
Review
Gstraunthaler et al., Innsbruck, Austria. In Am J Physiol Renal Physiol, 2014
The cells also express significant levels of the key gluconeogenic enzymes, fructose-1,6-bisphosphatase (FBPase) and phosphoenolpyruvate carboxykinase (PEPCK).
The mitochondrial isoform of phosphoenolpyruvate carboxykinase (PEPCK-M) and glucose homeostasis: has it been overlooked?
Review
Kibbey et al., Australia. In Biochim Biophys Acta, 2014
Similarly, gluconeogenesis from phosphoenolpyruvate (PEP) is believed to be the primarily pathway via the cytosolic isoform of phosphoenolpyruvate carboxykinase (PEPCK-C).
Hepatitis C virus infection and insulin resistance.
Review
Ray et al., Saint Louis, United States. In World J Diabetes, 2014
Various mechanisms have been proposed in regard to HCV mediated insulin resistance, involving up regulation of inflammatory cytokines, like tumor necrosis factor-α, phosphorylation of insulin-receptor substrate-1, Akt, up-regulation of gluconeogenic genes like glucose 6 phosphatase, phosphoenolpyruvate carboxykinase 2, and accumulation of lipid droplets.
Tracking the fate of glomerular epithelial cells in vivo using serial multiphoton imaging in new mouse models with fluorescent lineage tags.
Impact
Peti-Peterdi et al., Los Angeles, United States. In Nat Med, 2013
In phosphoenolpyruvate carboxykinase (PEPCK)-GFP mice, serial MPM found PEC-to-podocyte migration and nanotubule connections.
Exocytosis and Endocytosis of Small Vesicles across the Plasma Membrane in Saccharomyces cerevisiae.
Review
Chiang et al., State College, United States. In Membranes (basel), 2013
When Saccharomyces cerevisiae is starved of glucose, the gluconeogenic enzymes fructose-1,6-bisphosphatase (FBPase), phosphoenolpyruvate carboxykinase, isocitrate lyase, and malate dehydrogenase, as well as the non-gluconeogenic enzymes glyceraldehyde-3-phosphate dehydrogenase and cyclophilin A, are secreted into the periplasm.
[Hepatitis C virus core protein upregulates the transcription of PCK1 through FOXO1/PGC-1alpha pathway].
GeneRIF
Xu et al., Nanjing, China. In Wei Sheng Wu Xue Bao, 2012
HCV core protein expression-mediated FOXO1 activation and the increased PGC-1alpha leaded to the elevation of PCK1 at the mRNA level
Cryptochromes mediate rhythmic repression of the glucocorticoid receptor.
Impact
Evans et al., Los Angeles, United States. In Nature, 2012
Genomically, cryptochromes 1 and 2 associate with a glucocorticoid response element in the phosphoenolpyruvate carboxykinase 1 promoter in a hormone-dependent manner, and dexamethasone-induced transcription of the phosphoenolpyruvate carboxykinase 1 gene was strikingly increased in cryptochrome-deficient livers.
Acetylation regulates gluconeogenesis by promoting PEPCK1 degradation via recruiting the UBR5 ubiquitin ligase.
GeneRIF
Zhao et al., Shanghai, China. In Mol Cell, 2011
Acetylation regulates the stability of the gluconeogenic rate-limiting enzyme PEPCK1.
Down-regulation of the phosphoenolpyruvate carboxykinase gene in human colon tumors and induction by omega-3 fatty acids.
GeneRIF
Forest et al., Paris, France. In Biochimie, 2010
Data show PEPCK-C and CPT-1 mRNAs are more abundant in non-tumoral tissues than in the tumoral counterpart, whereas the opposite occurred for the FAS gene.
Lack of association between PCK1 polymorphisms and obesity, physical activity, and fitness in European Youth Heart Study (EYHS).
GeneRIF
Loos et al., Cambridge, United Kingdom. In Obesity (silver Spring), 2010
Study in the EYHS cohort failed to identify an association of PCK1 polymorphisms with obesity, physical activity, and fitness.
Identification of a novel selective inverse agonist probe and analogs for the Retinoic acid receptor-related Orphan Receptor Alpha (RORα)
Review
Griffin et al., Bethesda, United States. In Unknown Journal, 2010
Furthermore, ML176 suppresses the expression of endogenous RORα target genes in HepG2 cells that are involved in hepatic gluconeogenesis including glucose-6-phosphatase (G6Pase) and phosphoenolpyruvate carboxykinase (PEPCK).
Regulation of cellular metabolism by protein lysine acetylation.
Impact
Guan et al., Shanghai, China. In Science, 2010
Acetylation activated enoyl-coenzyme A hydratase/3-hydroxyacyl-coenzyme A dehydrogenase in fatty acid oxidation and malate dehydrogenase in the TCA cycle, inhibited argininosuccinate lyase in the urea cycle, and destabilized phosphoenolpyruvate carboxykinase in gluconeogenesis.
A putative Alzheimer's disease risk allele in PCK1 influences brain atrophy in multiple sclerosis.
GeneRIF
De Jager et al., Boston, United States. In Plos One, 2009
Studies demonstrate the association between PCK1 and smaller average brain volume.
Protein acetylation microarray reveals that NuA4 controls key metabolic target regulating gluconeogenesis.
Impact
Zhu et al., Baltimore, United States. In Cell, 2009
Among these, acetylation sites (Lys19 and 514) of phosphoenolpyruvate carboxykinase (Pck1p) were determined by tandem mass spectrometry.
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