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Jumonji domain containing 6

phosphatidylserine receptor, PS-R, Jmjd6, PTDSR
This gene encodes a nuclear protein with a JmjC domain. JmjC domain-containing proteins are predicted to function as protein hydroxylases or histone demethylases. This protein was first identified as a putative phosphatidylserine receptor involved in phagocytosis of apoptotic cells; however, subsequent studies have indicated that it does not directly function in the clearance of apoptotic cells, and questioned whether it is a true phosphatidylserine receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: V1a, CAN, HAD, Jumonji, TIM-4
Papers on phosphatidylserine receptor
Enhanced efferocytosis by dendritic cells underlies memory T-cell expansion and susceptibility to autoimmune disease in CD300f-deficient mice.
New
Coligan et al., Rockville, United States. In Cell Death Differ, Feb 2016
CD300f (CLM-1) is a phosphatidylserine receptor known to positively regulate efferocytosis by macrophages, and CD300f gene-deficient mice are predisposed to develop a lupus-like disease.
Sensing of latent EBV infection through exosomal transfer of 5'pppRNA.
New
Pegtel et al., Amsterdam, Netherlands. In Proc Natl Acad Sci U S A, Feb 2016
In ex vivo tonsillar cultures, we observed that EBER1-loaded exosomes are preferentially captured and internalized by human plasmacytoid DCs (pDCs) that express the TIM1 phosphatidylserine receptor, a known viral- and exosomal target.
Phenotypic and functional characterization of macrophages with therapeutic potential generated from human cirrhotic monocytes in a cohort study.
New
Forbes et al., Edinburgh, United Kingdom. In Cytotherapy, Nov 2015
METHODS: Infusion of human macrophages in a murine liver fibrosis model demonstrated a decrease in markers of liver injury (alanine transaminase, bilirubin, aspartate transaminase) and fibrosis (transforming growth factor-β, α-smooth muscle actin, phosphatidylserine receptor) and an increase in markers of liver regeneration (matrix metalloproteinases [MMP]-9, MMP-12 and TNF-related weak inducer of apoptosis).
KIM-1-/TIM-1-mediated phagocytosis links ATG5-/ULK1-dependent clearance of apoptotic cells to antigen presentation.
New
Bonventre et al., Boston, United States. In Embo J, Nov 2015
KIM-1/TIM-1 is a phosphatidylserine receptor that is expressed on epithelial cells and can transform the cells into phagocytes.
The oxygenase Jmjd6--a case study in conflicting assignments.
Review
New
Wolf et al., München, Germany. In Biochem J, Jul 2015
The Jumonji domain-containing protein 6 (Jmjd6) is a member of the superfamily of non-haem iron(II) and 2-oxoglutarate (2OG)-dependent oxygenases; it plays an important developmental role in higher animals.
Intronic regulation of Aire expression by Jmjd6 for self-tolerance induction in the thymus.
Yoshinori et al., Fukuoka, Japan. In Nat Commun, 2014
Here, we show that Jmjd6, a dioxygenase that catalyses lysyl hydroxylation of splicing regulatory proteins, is critical for Aire expression.
Kidney injury molecule-1: a translational journey.
Review
Bonventre, Boston, United States. In Trans Am Clin Climatol Assoc, 2013
KIM-1 is a phosphatidylserine receptor which recognizes apoptotic cells directing them to lysosomes.
Phosphatidylserine receptor BAI1 and apoptotic cells as new promoters of myoblast fusion.
Impact
Ravichandran et al., Charlottesville, United States. In Nature, 2013
Collectively, these data identify apoptotic cells as a new type of cue that induces signalling via the phosphatidylserine receptor BAI1 to promote fusion of healthy myoblasts, with important implications for muscle development and repair.
Endothelial microparticle uptake in target cells is annexin I/phosphatidylserine receptor dependent and prevents apoptosis.
GeneRIF
Werner et al., Bonn, Germany. In Arterioscler Thromb Vasc Biol, 2012
Endothelial microparticles are incorporated by endothelial cells in an annexin I/phosphatidylserine receptor-dependent manner and protect target cells against apoptosis.
The hydroxylation activity of Jmjd6 is required for its homo-oligomerization.
GeneRIF
Chen et al., Shanghai, China. In J Cell Biochem, 2012
we did not detect arginine demethylase activity for Jmjd6, but we did confirm that it could catalyze the lysyl-hydroxylation of histone peptides
Jumonji domain-containing protein 6 (Jmjd6) is required for angiogenic sprouting and regulates splicing of VEGF-receptor 1.
GeneRIF
Dimmeler et al., Frankfurt am Main, Germany. In Proc Natl Acad Sci U S A, 2011
Jmjd6 regulates the splicing of Flt1, thereby controlling angiogenic sprouting.
Unexpected requirement for ELMO1 in clearance of apoptotic germ cells in vivo.
Impact
Ravichandran et al., Charlottesville, United States. In Nature, 2010
ELMO1 is an evolutionarily conserved cytoplasmic engulfment protein that functions downstream of the phosphatidylserine receptor BAI1, and, along with DOCK1 and the GTPase RAC1, promotes internalization of the dying cells.
Interaction of JMJD6 with single-stranded RNA.
GeneRIF
Zhang et al., Denver, United States. In Proc Natl Acad Sci U S A, 2010
Data show that JMJD6 bound efficiently to single-stranded RNA, but not to single-stranded DNA, double-stranded RNA, or double-stranded DNA.
Crystal structure of the 2-oxoglutarate- and Fe(II)-dependent lysyl hydroxylase JMJD6.
GeneRIF
Schofield et al., Oxford, United Kingdom. In J Mol Biol, 2010
crystallographic studies on the catalytic domain of JMJD6 in complex with Ni(II) substituting for Fe(II)
Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing.
Impact
GeneRIF
Böttger et al., Oxford, United Kingdom. In Science, 2009
study reveals the splicing factor U2AF65 undergoes posttranslational lysyl-5-hydroxylation catalyzed by Jmjd6; Jmjd6 is shown to change alternative RNA splicing of some endogenous & reporter genes, supporting a role for Jmjd6 in regulation of RNA splicing
Archaeosome adjuvants: immunological capabilities and mechanism(s) of action.
Review
Sprott et al., Ottawa, Canada. In Vaccine, 2008
The polar lipid from the archaeon, Methanobrevibacter smithii has been well characterized for its adjuvant potential, and is abundant in archaetidyl serine, promoting interaction with a phosphatidylserine receptor on APCs.
Identification of Tim4 as a phosphatidylserine receptor.
Impact
Nagata et al., Kyoto, Japan. In Nature, 2007
In programmed cell death, a large number of cells undergo apoptosis, and are engulfed by macrophages to avoid the release of noxious materials from the dying cells.
Engulfment is required for cell competition.
Impact
Baker et al., United States. In Cell, 2007
The engulfment genes draper, wasp, the phosphatidylserine receptor, mbc/dock180, and rac1 are needed in wild-type cells for the death of Minute neighbors, whose corpses are engulfed by wild-type cells.
Changing story of the receptor for phosphatidylserine-dependent clearance of apoptotic cells.
Review
Böttger et al., Martinsried, Germany. In Embo Rep, 2007
The phosphatidylserine receptor (PSR) was originally described as the putative receptor for phosphatidylserine, which is displayed on the outer membrane leaflet of apoptotic cells as a so-called 'eat me' signal.
Cancer cell immune escape and tumor progression by exploitation of anti-inflammatory and pro-inflammatory responses.
Review
Tanabe et al., Hiroshima, Japan. In Cancer Biol Ther, 2005
Apoptotic cells can be eliminated by phagocytosis, which is mediated by antigen-presenting cells (APCs), such as macrophages and dendritic cells (DCs), through phosphatidylserine (PS) on apoptotic cells and phosphatidylserine receptor (PSR) on APCs.
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