Turning off AKT: PHLPP as a drug target.
San Diego, United States. In Annu Rev Pharmacol Toxicol, 2013
Pleckstrin homology domain leucine-rich repeat protein phosphatase (PHLPP) isozymes comprise a novel tumor suppressor family whose two members, PHLPP1 and PHLPP2, are deleted as frequently as PTEN in cancers such as those of the prostate.
PHLiPPing the switch on Akt and protein kinase C signaling.
San Diego, United States. In Trends Endocrinol Metab, 2008
The two isoforms of this recently discovered family, PHLPP1 and PHLPP2, control the amplitude and duration of signaling of Akt and PKC by catalyzing the dephosphorylation of the hydrophobic phosphorylation motif, a C-terminal phosphorylation switch that controls these kinases.