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PHD finger protein 10

PHF10, BAF45a, XAP135
This gene contains a predicted ORF that encodes a protein with two zinc finger domains. The function of the encoded protein is not known. Sequence analysis suggests that multiple alternatively spliced transcript variants are derived from this gene but the full-length nature of only two of them is known. These two splice variants encode different isoforms. A pseudogene for this gene is located on Xq28. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: SWI, delta1, TBP, HAD, DPF-1
Papers on PHF10
The SWI/SNF Subunit INI1 Contains an N-Terminal Winged Helix DNA Binding Domain that Is a Target for Mutations in Schwannomatosis.
New
Bycroft et al., Stockholm, Sweden. In Structure, Aug 2015
Here, we show that mutations in INI1 that cause schwannomatosis target a hitherto unidentified N-terminal winged helix DNA binding domain that is also present in the BAF45a/PHF10 subunit of the SWI/SNF complex.
Delineation of candidate genes responsible for structural brain abnormalities in patients with terminal deletions of chromosome 6q27.
Review
Cheung et al., Houston, United States. In Eur J Hum Genet, 2015
The smallest region of overlap spans 1.7 Mb and contains DLL1, THBS2, PHF10, and C6orf70 (ERMARD) that are plausible candidates for the causation of structural brain abnormalities.
Mammalian cells contain two functionally distinct PBAF complexes incorporating different isoforms of PHF10 signature subunit.
Soshnikova et al., Moscow, Russia. In Cell Cycle, 2013
Human PHF10/BAF45a subunit of the PBAF complex plays an important role in brain development but has not been studied sufficiently.
SAYP and Brahma are important for 'repressive' and 'transient' Pol II pausing.
Georgieva et al., Moscow, Russia. In Nucleic Acids Res, 2012
Drosophila SAYP, a homologue of human PHF10/BAF45a, is a metazoan coactivator associated with Brahma and essential for its recruitment on the promoter.
Genetic and functional evaluation of the role of DLL1 in susceptibility to visceral leishmaniasis in India.
Blackwell et al., Benares, India. In Infect Genet Evol, 2012
Twenty-one single nucleotide polymorphisms (SNPs) at PHF10/C6orf70/DLL1/FAM120B/PSMB1/TBP were genotyped in 941 cases and 992 controls.
MicroRNA-409-3p regulates cell proliferation and apoptosis by targeting PHF10 in gastric cancer.
Liu et al., Shanghai, China. In Cancer Lett, 2012
Furthermore, we demonstrate that the transcriptional regulator PHF10 was a target of miR-409-3p.
Double plant homeodomain (PHD) finger proteins DPF3a and -3b are required as transcriptional co-activators in SWI/SNF complex-dependent activation of NF-κB RelA/p50 heterodimer.
Iba et al., Tokyo, Japan. In J Biol Chem, 2012
Using sensitive 293FT reporter cell clones that had integrated a SWI/SNF-dependent NF-κB reporter gene, we find in this study that the overexpression of DPF1, DPF2, DPF3a, DPF3b, and PHF10 significantly potentiates the transactivating activity of typical NF-κB dimers.
Transcription co-activator SAYP mediates the action of STAT activator.
Shidlovskii et al., Moscow, Russia. In Nucleic Acids Res, 2012
We describe participation of metazoan co-activator SAYP/PHF10 in this pathway downstream of STAT.
SS18 together with animal-specific factors defines human BAF-type SWI/SNF complexes.
Logie et al., Nijmegen, Netherlands. In Plos One, 2011
By contrast,we demonstrate that human PHF10 is part of the PBAF complex, which harbors both ARID2/BAF200 and polybromo/BAF180 subunits, but not SS18 and nor the above BAF-specific subunits.
A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci.
Hakonarson et al., Philadelphia, United States. In Plos Genet, 2011
The third most significantly associated SNP (rs924043, P = 8.06×10⁻⁹ lies in an intergenic region on 6q27, where the region of association is approximately 900 kb and harbors multiple genes including WDR27, C6orf120, PHF10, TCTE3, C6orf208, LOC154449, DLL1, FAM120B, PSMB1, TBP, and PCD2.
MicroRNA-mediated conversion of human fibroblasts to neurons.
Impact
Crabtree et al., Stanford, United States. In Nature, 2011
After mitotic exit, BAF53a is replaced by BAF53b, and BAF45a by BAF45b and BAF45c, which are then incorporated into neuron-specific (n)BAF complexes essential for post-mitotic functions.
Genetic and functional evidence implicating DLL1 as the gene that influences susceptibility to visceral leishmaniasis at chromosome 6q27.
Blackwell et al., Cambridge, United Kingdom. In J Infect Dis, 2011
METHODS: Twenty-two single-nucleotide polymorphisms (SNPs) at genes PHF10, C6orf70, DLL1, FAM120B, PSMB1, and TBP were genotyped in 193 VL cases from 85 Sudanese families, and 8 SNPs at genes PHF10, C6orf70, DLL1, PSMB1, and TBP were genotyped in 194 VL cases from 80 Brazilian families.
[Preparation of PHF10 antibody and analysis of PHF10 expression gastric cancer tissues].
Gu et al., Shanghai, China. In Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2010
AIM: To prepare PHF10 antibody and check the expression of PHF10 protein in the tissues of gastric cancer and adjacent tissue.
A novel plant homeodomain finger 10-mediated antiapoptotic mechanism involving repression of caspase-3 in gastric cancer cells.
GeneRIF
Gu et al., Shanghai, China. In Mol Cancer Ther, 2010
PHF10 repressed caspase-3 expression and impaired the programmed cell death pathway in human gastric cancer at the transcriptional level.
MicroRNA-mediated switching of chromatin-remodelling complexes in neural development.
Impact
Crabtree et al., Stanford, United States. In Nature, 2009
This switch involves the exchange of the BAF53a (also known as ACTL6a) and BAF45a (PHF10) subunits within Swi/Snf-like neural-progenitor-specific BAF (npBAF) complexes for the homologous BAF53b (ACTL6b) and BAF45b (DPF1) subunits within neuron-specific BAF (nBAF) complexes in post-mitotic neurons.
PHF10 is required for cell proliferation in normal and SV40-immortalized human fibroblast cells.
GeneRIF
Ozer et al., Newark, United States. In Cytogenet Genome Res, 2008
Data show that that PHF10 is required for cell growth.
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