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PHD finger protein 1

PHF-1
This gene encodes a Polycomb group protein. The protein is a component of a histone H3 lysine-27 (H3K27)-specific methyltransferase complex, and functions in transcriptional repression of homeotic genes. The protein is also recruited to double-strand breaks, and reduced protein levels results in X-ray sensitivity and increased homologous recombination. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009] (from NCBI)
Top mentioned proteins: CAN, ACID, AGE, HAD, Phospho
Papers on PHF-1
Hypothermia mediates age-dependent increase of tau phosphorylation in db/db mice.
New
Planel et al., Québec, Canada. In Neurobiol Dis, Feb 2016
26-week-old db/db mice displayed tau hyperphosphorylation at multiple epitopes (CP13, AT8, PHF-1), but no obvious change in kinases or phosphatases, no cleavage of tau, and no deregulation of central insulin signaling pathways.
Ossifying fibromyxoid tumor: morphology, genetics, and differential diagnosis.
Review
New
Thway et al., London, United Kingdom. In Ann Diagn Pathol, Jan 2016
It is now established that OFMTs represent translocation-associated tumors, with up to 85% associated with recurrent gene rearrangements, mostly involving the PHF1 gene (including in typical, atypical, and malignant neoplasms), with EP400-PHF1 in approximately 40% of tumors, and ZC3H7B-BCOR, MEAF6-PHF1, and EPC1-PHF1 fusions also described.
Analysis of MDM2 Amplification in 43 Endometrial Stromal Tumors: A Potential Diagnostic Pitfall.
New
Nucci et al., Boston, United States. In Int J Gynecol Pathol, Nov 2015
In addition, 40 of the 43 cases had previously undergone fluorescence in situ hybridization analysis of JAZF1, PHF1, and YHWAE.
Genomic landscape of endometrial stromal sarcoma of uterus.
New
Lee et al., Seoul, South Korea. In Oncotarget, Nov 2015
All three LG-ESSs exhibited either one of JAZF1-SUZ12, JAZF1-PHF1 and MEAF6-PHF1 fusions, whereas the two UUSs did not.
Multi-target iron-chelators improve memory loss in a rat model of sporadic Alzheimer's disease.
New
Youdim et al., Zagreb, Croatia. In Life Sci, Oct 2015
Chronic M30 treatment fully restored (−47%/PHF1;−65%/AT8; p b 0.05) STZ-induced hyperphosphorylation of tau protein and normalized decreased expression of insulin degrading enzyme (+37%; p b 0.05) in hippocampus.
Effect of treadmill exercise on PI3K/AKT/mTOR, autophagy, and Tau hyperphosphorylation in the cerebral cortex of NSE/htau23 transgenic mice.
New
Cho et al., Seoul, South Korea. In J Exerc Nutrition Biochem, Sep 2015
Western blot was conducted to determine the phosphorylation status of PI3K/AKT/mTOR proteins and autophagy-related proteins (Beclin-1, p62, LC3-B); hyperphosphorylation and aggregation of tau protein (Ser199/202, Ser404, Thr231, PHF-1); and phosphorylation of GSK-3β, which is involved in the phosphorylation of tau protein in the cerebral cortex of experimental animals.
Parkinson's disease-associated PINK1 G309D mutation increases abnormal phosphorylation of Tau.
New
Sun et al., Suzhou, China. In Iubmb Life, Apr 2015
Cells transfected with mutant G309D PINK1 exhibited a significant increase in the phosphorylation of tau protein at the PHF-1 (ser396/404) site.
An aromatic cage is required but not sufficient for binding of Tudor domains of the Polycomblike protein family to H3K36me3.
Kutateladze et al., Aurora, United States. In Epigenetics, 2014
Polycomblike (Pcl) proteins are important transcriptional regulators and components of the Polycomb Repressive Complex 2 (PRC2).
Comparative analysis of autophagy and tauopathy related markers in cerebral ischemia and Alzheimer's disease animal models.
Cardona-Gomez et al., Medellín, Colombia. In Front Aging Neurosci, 2014
We proposed that this phenomenon was associated with autophagy induction in the late stage, since the data showed a decrease in p-mTOR activity, an association of Beclin-1 and Vps34, a progressive reduction in PHF-1, an increase in LC3B puncta and autophago-lysosomes formation were observed.
Atypical ossifying fibromyxoid tumor unusually located in the mediastinum: report of a case showing mosaic loss of INI-1 expression.
Koda et al., Shizuoka, Japan. In Int J Clin Exp Pathol, 2014
Inactivation of INI-1 gene and deregulation of PHF1 gene are thought to be involved in tumorigenesis of OFMT.
Preventive methylene blue treatment preserves cognition in mice expressing full-length pro-aggregant human Tau.
Mandelkow et al., Hamburg, Germany. In Acta Neuropathol Commun, 2014
Beside improved learning and memory, MB-treated Tau(ΔK) mice showed a strong decrease of insoluble Tau, a reduction of conformationally changed (MC1) and phosphorylated Tau species (AT180, PHF1) as well as an upregulation of protein degradation systems (autophagy and proteasome).
Caspase-Cleaved Tau Co-Localizes with Early Tangle Markers in the Human Vascular Dementia Brain.
Rohn et al., Irvine, United States. In Plos One, 2014
Staining of the TauC3 antibody co-localized with MC-1, AT8, and PHF-1 within NFTs.
Tudor: a versatile family of histone methylation 'readers'.
Review
Wang et al., Chapel Hill, United States. In Trends Biochem Sci, 2013
Here, we discuss novel functions of a number of Tudor-containing proteins [including Jumonji domain-containing 2A (JMJD2A), p53-binding protein 1 (53BP1), SAGA-associated factor 29 (SGF29), Spindlin1, ubiquitin-like with PHD and RING finger domains 1 (UHRF1), PHD finger protein 1 (PHF1), PHD finger protein 19 (PHF19), and SAWADEE homeodomain homolog 1 (SHH1)] in 'reading' unique methylation events on histones in order to facilitate DNA damage repair or regulate transcription.
Recurrent rearrangement of the PHF1 gene in ossifying fibromyxoid tumors.
GeneRIF
Mertens et al., Lund, Sweden. In Am J Pathol, 2012
The PHF1 gene, previously shown to be the 3'-partner of fusion genes in endometrial stromal tumors, is also recurrently involved in the pathogenesis of ossifying fibromyxoid tumors.
Change in tau phosphorylation associated with neurodegeneration in the ME7 model of prion disease.
Review
O'Connor et al., Southampton, United Kingdom. In Biochem Soc Trans, 2010
We observed no differences in the levels of phosphorylated tau (using MC1, PHF-1 and CP13 antibodies) in detergent-soluble and detergent-insoluble fractions extracted from ME7- and NBH- (normal brain homogenate) treated animals across disease.
An endometrial stromal sarcoma cell line with the JAZF1/PHF1 chimera.
GeneRIF
Griffin et al., Lund, Sweden. In Cancer Genet Cytogenet, 2008
predicted 684-amino acid JAZF1/PHF1 chimeric protein retained one zinc finger domain from JAZF1 and the two zinc finger domains from PHF1, and its oncogenic mechanism should be similar to that of the JAZF1/SUZ12 protein
A polycomb group protein, PHF1, is involved in the response to DNA double-strand breaks in human cell.
GeneRIF
Yasui et al., Sendai, Japan. In Nucleic Acids Res, 2008
PHF1 interacts physically with Ku70/Ku80, suggesting that PHF1 promotes nonhomologous end-joining processes.
Ezh2 requires PHF1 to efficiently catalyze H3 lysine 27 trimethylation in vivo.
GeneRIF
Reinberg et al., New York City, United States. In Mol Cell Biol, 2008
PHF1 modulates the activity of Ezh2 in favor of the repressive H3K27me3 mark
Mutations of t-complex testis expressed gene 5 transcripts in the testis of sterile t-haplotype mutant mouse.
GeneRIF
Haines et al., Hong Kong, Hong Kong. In Asian J Androl, 2008
We established that mutations that occur in the Tctex5 long transcript of the t-haplotype mice are important for normal sperm function, whereas the short transcript of Tctex5 might have a conserved function among different tissues.
Cultured cell and transgenic mouse models for tau pathology linked to beta-amyloid.
Review
Glabe et al., Charlottesville, United States. In Biochim Biophys Acta, 2005
We report here that continuous exposure to 5 microM non-fibrillar Abeta40 or Abeta42 kills primary brain cells by apoptosis within 2-3 weeks, Abeta42 is more toxic and selective for neurons than Abeta40, and Abeta42, but not Abeta40, induces a transient increase in neurons that are positive for the AD-like PHF1 epitope.
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