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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.


Phenylethanolamine N-Methyltransferase, PNMT, Phosphatidylethanolamine N-Methyltransferase
catalyzes the conversion of norepinephrine to epinephrine in catecholamine biosynthesis [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: Dopamine beta-Hydroxylase, HAD, CAN, ACID, V1a
Papers on Phenylethanolamine N-Methyltransferase
Phosphatidylethanolamine N-methyltransferase gene rs7946 polymorphism plays a role in risk of nonalcoholic fatty liver disease: evidence from meta-analysis.
Zain et al., Kuala Lumpur, Malaysia. In Pharmacogenet Genomics, Feb 2016
BACKGROUND: Phosphatidylethanolamine N-methyltransferase (PEMT) governs the secretion of hepatic triglycerides in the form of very low-density lipoprotein and has been implicated in nonalcoholic fatty liver disease (NAFLD).
Plasma 1-carbon metabolites and academic achievement in 15-yr-old adolescents.
Zeisel et al., Umeå, Sweden. In Faseb J, Feb 2016
In a sample of 15-yr-old children (n = 324), we measured plasma concentrations of homocysteine, choline, and betaine and genotyped them for 2 polymorphisms with effects on 1-CM, methylenetetrahydrofolate reductase (MTHFR) 677C>T, rs1801133, and phosphatidylethanolamine N-methyltransferase (PEMT), rs12325817 (G>C).
Cushing syndrome due to ACTH-secreting pheochromocytoma aggravated by a glucocorticoid-driven positive-feedback loop.
Tanaka et al., Chiba, Japan. In J Clin Endocrinol Metab, Jan 2016
Furthermore, gene expression and in vitro functional analyses using primary tumor tissue cultures demonstrated that dexamethasone facilitated ACTH as well as catecholamine secretion with parallel induction of proopiomelanocortin (POMC), TH, and phenylethanolamine N-methyltransferase mRNA, supporting a glucocorticoid-dependent positive-feedback loop of ACTH secretion in vivo.
Neural crest-derived resident cardiac cells contribute to the restoration of adrenergic function of transplanted heart in rodent.
Fukuda et al., Tokyo, Japan. In Cardiovasc Res, Jan 2016
The mRNA expression levels of tyrosine hydroxylase, dopamine-β-hydroxylase and phenylethanolamine N-methyltransferase, and the tissue content of catecholamines in the transplanted hearts increased with time in association with an increase in the number of neural crest-derived nucleated tyrosine hydroxylase-immunoreactive cells and tissue nerve growth factor levels.
Cardiac phenylethanolamine N-methyltransferase: localization and regulation of gene expression in the spontaneously hypertensive rat.
Tai et al., Greater Sudbury, Canada. In Can J Physiol Pharmacol, Nov 2015
UNASSIGNED: Phenylethanolamine N-methyltransferase (PNMT) is the terminal enzyme in the catecholamine biosynthetic pathway responsible for adrenaline biosynthesis.
How to prevent alcoholic liver disease.
French, Torrance, United States. In Exp Mol Pathol, Apr 2015
Betaine does this most likely by supporting the methylation of norepinephrine to form epinephrine by phenylethanolamine N-methyltransferase. Epinephrine is 5 to 10-fold more active than norepinephrine in increasing the metabolic rate.
Phospholipid methylation in mammals: from biochemistry to physiological function.
Vance, Edmonton, Canada. In Biochim Biophys Acta, 2014
Phosphatidylcholine is made in the liver via the CDP-choline pathway and via the conversion of phosphatidylethanolamine to phosphatidylcholine by 3 transmethylation reactions from AdoMet catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT).
Therapeutic potential of Pnmt+ primer cells for neuro/myocardial regeneration.
Ebert et al., Orlando, United States. In Am J Stem Cells, 2012
Phenylethanolamine n-methyltransferase (Pnmt) catalyzes the conversion of norepinephrine into epinephrine, and thus serves as a marker of adrenergic cells.
Stress-triggered changes in peripheral catecholaminergic systems.
Ziegler et al., Bratislava, Slovakia. In Adv Pharmacol, 2012
Nonneuronal phenylethanolamine N-methyltransferase (PNMT) develops early in the heart and then diminishes.
Fragment-based screening by protein crystallography: successes and pitfalls.
Oakley et al., Wollongong, Australia. In Int J Mol Sci, 2011
Some recent uses of crystallography in FBS will be described in detail, including interrogation of the drug targets β-secretase, phenylethanolamine N-methyltransferase, phosphodiesterase 4A and Hsp90.
Phenylethanolamine N-methyltransferase gene promoter haplotypes and risk of essential hypertension.
Yang et al., Changsha, China. In Am J Hypertens, 2011
The 2-SNP AA haplotype in the PNMT promoter is associated with decreased risk of essential hypertension in Han Chinese.
Polymorphic variants of folate and choline metabolism genes and the risk of endometriosis-associated infertility.
Jagodziński et al., Poland. In Eur J Obstet Gynecol Reprod Biol, 2011
genetic association studies on endometriosis in a population of women in Poland: Data suggest interaction between an SNP in PEMT (rs4244593) and an SNP in MTHFR (Ala222Val; rs1801133) in infertile women with some indication of endometriosis.
Docosahexaenoic acid in plasma phosphatidylcholine may be a potential marker for in vivo phosphatidylethanolamine N-methyltransferase activity in humans.
Zeisel et al., Chapel Hill, United States. In Am J Clin Nutr, 2011
nvestigation of factors affecting liver PEMT activity: PEMT activity is lower in liver samples from women who are homozygous for an SNP in PEMT (rs12325817)
Regulation of catecholamine-synthesising enzymes and beta-adrenoceptors gene expression in ventricles of stressed rats.
Dronjak et al., Belgrade, Serbia. In Physiol Res, 2010
Stress elevated PNMT levels in heart ventricles.
Role of reactive oxygen species in the neural and hormonal regulation of the PNMT gene in PC12 cells.
Tai et al., Greater Sudbury, Canada. In Oxid Med Cell Longev, 2010
Findings demonstrate that CoCl(2)-induced ROS have synergistic effects on hormonal and neural activation of the PNMT promoter.
Genomic and transcriptional aberrations linked to breast cancer pathophysiologies.
Gray et al., San Francisco, United States. In Cancer Cell, 2006
Nine of these (FGFR1, IKBKB, ERBB2, PROCC, ADAM9, FNTA, ACACA, PNMT, and NR1D1) are considered druggable.
The ratio of phosphatidylcholine to phosphatidylethanolamine influences membrane integrity and steatohepatitis.
Vance et al., Edmonton, Canada. In Cell Metab, 2006
In liver, PC is synthesized via the choline pathway or by methylation of PE via phosphatidylethanolamine N-methyltransferase (PEMT).
Molecular control of cell fate in the neural crest: the sympathoadrenal lineage.
Anderson, Pasadena, United States. In Annu Rev Neurosci, 1992
In the chromaffin branch of the pathway, which molecules control the timing of PNMT expression?
Pharmacology of brain epinephrine neurons.
Fuller, In Annu Rev Pharmacol Toxicol, 1981
Neurons that contain PNMT, the epinephrine-forming enzyme, have their cell bodies in brain stem regions in rat brain and send projections mainly into other brain stem areas, hypothalamus, and spinal cord.
Choline biosynthesis by a preparation enriched in synaptosomes from rat brain.
Wurtman et al., In Nature, 1981
Recently we and others have demonstrated that various preparations of mammalian brain contain enzymes, the phosphatidylethanolamine N-methyltransferase (PeMT), which catalyse the synthesis of phosphatidylcholine (PC), using S-adenosylmethionine (SAM) as a methyl donor for the stepwise methylation of phosphatidylethanolamine (PE).
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