Roles of renal erythropoietin-producing (REP) cells in the maintenance of systemic oxygen homeostasis.
Sendai, Japan. In Pflugers Arch, Jan 2016
In fact, the loss of Epo production in REP cells causes chronic severe anemia in genetically modified mice, and REP cell-specific inactivation of PHD2 (prolyl-hydroxylase domain enzyme 2) results in erythrocytosis via overexpression of the Epo gene due to the constitutive activation of HIF2α (hypoxia-inducible transcription factor 2α). REP cells are located in the interstitial spaces between renal tubules and capillaries, where the oxygen supply is low but oxygen consumption is high, for the highly sensitive detection of decreased oxygen supplies to the body.
A lactate-induced response to hypoxia.
Taejŏn, South Korea. In Cell, May 2015
We find that the NDRG3 protein is degraded in a PHD2/VHL-dependent manner in normoxia but is protected from destruction by binding to lactate that accumulates under hypoxia.
Pheochromocytomas and Paragangliomas: Clinical and Genetic Approaches.
Rio de Janeiro, Brazil. In Front Endocrinol (lausanne), 2014
The description of new genes linked to familial forms of PCC/PGLs, such as succinate dehydrogenase (SDH) complex subunits, KIF1Bβ, EGLN1, TMEM127, and MAX, added to the well-known PCC familial syndrome (MEN2, VHL, and neurofibromatosis type 1) presents new challenges for diagnosis.
Molecular oxygen sensing: implications for visceral surgery.
Heidelberg, Germany. In Langenbecks Arch Surg, 2012
Here, we outline specific functions of PHD enzymes in surgically relevant pathological conditions, and discuss how these functions might be exploited in order to support the treatment of surgically relevant diseases.