The role of hypoxia and Morg1 in renal injury.
Jena, Germany. In Eur J Clin Invest, Mar 2015
Under normoxic conditions constitutively expressed HIF-α subunits are hydroxylated by prolyl hydroxylases (PHD1, PHD2, and PHD3) and subsequently degraded by proteasomes.
Molecular oxygen sensing: implications for visceral surgery.
Heidelberg, Germany. In Langenbecks Arch Surg, 2012
Here, we outline specific functions of PHD enzymes in surgically relevant pathological conditions, and discuss how these functions might be exploited in order to support the treatment of surgically relevant diseases.