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Lamin B receptor

The protein encoded by this gene belongs to the ERG4/ERG24 family. It localized in the nuclear envelope inner membrane and anchors the lamina and the heterochromatin to the membrane. It may mediate interaction between chromatin and lamin B. Mutations of this gene has been associated with autosomal recessive HEM/Greenberg skeletal dysplasia. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, ACID, V1a, Interleukin-2
Papers using PHA antibodies
Differential regulation of cytokine production by PI3Kdelta in human monocytes upon acute and chronic inflammatory conditions.
Bozza Patricia T., In PLoS ONE, 2007
... (Gibco, Paisley, Scotland); purified phytohemagglutinin (PHA) (EY Laboratories, San Marco, CA); TriReagent, ...
Toxicology of the Yessotoxins
MacKinnon Shawna L. et al., In Toxins, 2007
... PHA543613 hydrochloride (PHA) was obtained from Tocris Bioscience (Ellisville, MO, USA) ...
Concerted regulation of focal adhesion dynamics by galectin-3 and tyrosine-phosphorylated caveolin-1
Nabi Ivan R. et al., In The Journal of Cell Biology, 2006
... L-PHA-HRP was purchased from EY Laboratories.
Role of HMGB1 in apoptosis-mediated sepsis lethality
Xiong Lize et al., In Journal of Neuroinflammation, 2005
... PHA-543,613 hydrochloride was purchased from Tocris Bioscience (Ellisville, MO, USA), ...
Growing roles for the mTOR pathway
Wang Aiyuan et al., In Molecular Cancer, 2004
... 17-allyloamino-17-demethoxygeldanamycin (17-AAG) and gefitinib were obtained from LC Laboratories (Woburn, MA, USA) and PHA-665752 was from Tocris Biosciences (St ...
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Papers on PHA
Adult nephron-specific MR-deficient mice develop a severe renal PHA-1 phenotype.
Hummler et al., Lausanne, Switzerland. In Pflugers Arch, Feb 2016
Germline loss-of-function mutations of the mineralocorticoid receptor (MR) in humans and in mice lead to the "renal" form of type 1 pseudohypoaldosteronism (PHA-1), a case of aldosterone resistance characterized by salt wasting, dehydration, failure to thrive, hyperkalemia, and metabolic acidosis.
Infancy-onset T1DM, short stature and severe immunodysregulation in two siblings with a homozygous LRBA-mutation.
Woelfle et al., Bonn, Germany. In J Clin Endocrinol Metab, Feb 2016
The diagnosis LRBA-deficiency was confirmed by a FACS-based immunoassay showing absence of LRBA protein in PHA-stimulated PBMC.
In human T cells mifepristone antagonizes glucocorticoid non-genomic rapid responses in terms of Na(+)/H(+)-exchange 1 activity, but not ezrin/radixin/moesin phosphorylation.
Lin et al., Taipei, Taiwan. In Steroids, Feb 2016
Intracellular acidification by GCs is due to a rapid non-genomic inhibition of membrane Na(+)/H(+)-exchange 1 (NHE1) activity and is followed by immunosuppression of PHA-stimulated proliferation.
Human umbilical cord-derived mesenchymal stem cells suppress proliferation of PHA-activated lymphocytes in vitro by inducing CD4(+)CD25(high)CD45RA(+) regulatory T cell production and modulating cytokine secretion.
Qu et al., Jinan, China. In Cell Immunol, Feb 2016
We found that UC-MSCs efficiently suppressed the proliferation of phytohaemagglutinin (PHA)-stimulated PBMCs (p<0.01).
In Science, Dec 2015
ERRATUM FOR THE REPORT "Recruitment of RNA polymerase II by the pioneer transcription factor PHA-4" by H.-T. Hsu et al., Science 350, aad5928 (2015).
Class IV polyhydroxyalkanoate (PHA) synthases and PHA-producing Bacillus.
Mizuno et al., Yokohama, Japan. In Appl Microbiol Biotechnol, Aug 2015
This review highlights the recent investigations of class IV polyhydroxyalkanoate (PHA) synthases, the newest classification of PHA synthases.
TRANSCRIPTION. Recruitment of RNA polymerase II by the pioneer transcription factor PHA-4.
Mango et al., Cambridge, United States. In Science, Jul 2015
In early Caenorhabditis elegans foregut development, the pioneer factor PHA-4/FoxA binds promoters and recruits RNA polymerase II (Pol II), often in a poised configuration in which Pol II accumulates near transcription start sites.
Non-random distribution of macromolecules as driving forces for phenotypic variation.
Müller et al., Leipzig, Germany. In Curr Opin Microbiol, Jun 2015
Different types of segregation are described, addressing both metabolically pertinent molecules such as PHA/PHB or polyphosphates, and components that adversely affect cells by promoting aging, such as damaged protein complexes or extrachromosomal rDNA circles.
Smart polyhydroxyalkanoate nanobeads by protein based functionalization.
Prieto et al., Madrid, Spain. In Nanomedicine, May 2015
Production of functionalized bacterial polyhydroxyalkanoate (PHA) nanobeads by harnessing their natural carbon-storage granule production system is a thrilling recent development.
Structural Biology Insight for the Design of Sub-type Selective Aurora Kinase Inhibitors.
Coumar et al., Pondicherry, India. In Curr Cancer Drug Targets, 2014
The majority of the inhibitors (VX-680/MK-0457, PHA-739358, CYC116, SNS-314, AMG 900, AT-9283, SCH- 1473759, ABT-348, PF-03814735, R-763/AS-703569, KW-2449 and TAK-901) are pan-selective (isoform non-selective) and few are Aurora A (MLN8054, MLN8237, VX-689/MK5108 and ENMD 2076) and Aurora B (AZD1152 and GSK1070916) sub-type selective.
Polyhydroxyalkanoates: Much More than Biodegradable Plastics.
Méndez et al., Buenos Aires, Argentina. In Adv Appl Microbiol, 2014
The cycle of PHA synthesis and degradation has been recognized as an important physiological feature when these biochemical pathways were originally described, yet its role in bacterial processes as diverse as global regulation and cell survival is just starting to be appreciated in full.
Role of abnormal anterior pituitary hormones-growth hormone and prolactin in active systemic lupus erythematosus.
Li et al., Shanghai, China. In Int J Clin Exp Med, 2014
Enhanced IgG and anti-dsDNA secretion was observed in cultured PBMC stimulated by PRL or GH with/without PHA, PWM, IL-2 or IL-10.
Regulation of organismal proteostasis by transcellular chaperone signaling.
Morimoto et al., Evanston, United States. In Cell, 2013
This cell-nonautonomous control of HSP90 expression relies upon transcriptional feedback between somatic tissues that is regulated by the FoxA transcription factor PHA-4.
Temporal control of nuclear envelope assembly by phosphorylation of lamin B receptor.
Chen et al., Taipei, Taiwan. In Mol Biol Cell, 2011
Our studies reveal for the first time a mechanism that controls the timing of nuclear envelope reassembly through modification of the integral nuclear membrane protein lamin B receptor
N-acylethanolamine signalling mediates the effect of diet on lifespan in Caenorhabditis elegans.
Gill et al., Novato, United States. In Nature, 2011
Studies of the genetic requirements for lifespan extension by dietary restriction in the nematode Caenorhabditis elegans have implicated a number of key molecules in this process, including the nutrient-sensing target of rapamycin (TOR) pathway and the Foxa transcription factor PHA-4 (ref.
An in vitro model for Pelger-Huët anomaly: stable knockdown of lamin B receptor in HL-60 cells.
Olins et al., Brunswick, United States. In Nucleus, 2010
The LBR knockdown cells retain an ovoid shaped nucleus with reduced levels of lamin A/C during in vitro granulopoiesis induced with retinoic acid.
Mutations causing Greenberg dysplasia but not Pelger anomaly uncouple enzymatic from structural functions of a nuclear membrane protein.
Hoffmann et al., London, United Kingdom. In Nucleus, 2010
LBR missense mutations can abolish sterol reductase activity, causing lethal Greenberg dysplasia but not Pelger anomaly
Dosage effect of zero to three functional LBR-genes in vivo and in vitro.
Hoffmann et al., Berlin, Germany. In Nucleus, 2010
a highly significant gene-dosage effect between the gene copy number and the nuclear segmentation index of neutrophils
Nuclear shape in papillary thyroid carcinoma: a role for lamin B receptor?
Bussolati et al., Torino, Italy. In Rom J Morphol Embryol, 2009
LBR is heavily expressed in papillary thyroid carcinoma cells, but an abnormal folding of the protein might explain its lack of immunohistochemical reactivity and be associated with the anomalous folding of the nuclear membrane.
Phase I pharmacokinetic and pharmacodynamic study of the aurora kinase inhibitor danusertib in patients with advanced or metastatic solid tumors.
de Jonge et al., Leiden, Netherlands. In J Clin Oncol, 2009
PURPOSE: Danusertib (PHA-739358) is a small-molecule pan-aurora kinase inhibitor.
More papers using PHA antibodies
Compensation for a bad start: grow now, pay later?
Leonard Marty L., In PLoS ONE, 2000
... the evening, we injected into the left patagium of each chick 0.4 mg of phytohaemagglutinin (PHA-P, L-8754, Sigma Aldrich) diluted in 0.08 ml ...
Pesticide Fact Sheet
Holecková Beáta et al., In Genetics and Molecular Biology, 2000
... USA), 15% foetal calf serum, antibiotics (penicillin 250 U/mL and streptomycin 250 μg/mL), and phytohaemagglutinin (PHA, 180 μg/mL, Welcome, Dartford, England).Chromosome preparations were obtained by the standard cytogenetic method; 2 h before harvest, colchicine (Merck, Darmstadt, Germany) was added ...
Gads is a novel SH2 and SH3 domain-containing adaptor protein that binds to tyrosine-phosphorylated Shc
Sugamura Kazuo et al., In The Journal of Experimental Medicine, 1997
... Grf40 cDNA fragments were isolated by a yeast two-hybrid screen of a human PHA-PBL cDNA library (Clontech ...
Red-winged blackbird females fail to increase feeding in response to begging call playbacks
Leonard Marty L., In PLoS ONE, 1997
... the experiment, we injected into the left patagium of each chick 0.2 mg of phytohaemagglutinin (PHA-P, L-8754, Sigma Aldrich) diluted in 0.04 ml ...
Cortex: Areal and laminar structure
Bjaalie Jan G. et al., In Frontiers in Neuroscience, 1994
... -leucoagglutinin (Pha-L, Vector Laboratories, Burlingame, CA) ...
Induction of epithelial tubular morphogenesis in vitro by fibroblast-derived soluble factors
Chai Karl X., In PLoS ONE, 1990
... UO126 and Wortmannin were from LC Laboratories (Woburn, MA, USA) and were resuspended in DMSO; PHA-665752 was from Tocris Bioscience (Ellisville, MI, USA); ...
Cortico-striate projections in the rhesus monkey: the organization of certain cortico-caudate connections
Haber Suzanne N et al., In The European Journal of Neuroscience, 1977
... –leucoagglutinin (PHA-L; 50 nL, 2.5%; Vector Laboratories, Burlingame, CA, USA); or ...
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