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Phosphatidylglycerophosphate synthase 1

PGP synthase
Top mentioned proteins: PI3K, HAD, STEP, ACID, Cho
Papers on PGP synthase
StARD13(Dlc-2) RhoGap mediates ceramide activation of phosphatidylglycerolphosphate synthase and drug response in Chinese hamster ovary cells.
Mowat et al., Winnipeg, Canada. In Mol Biol Cell, 2008
RNA knockdown experiments of the Dlc2 RhoGap resulted in increased GTP-bound RhoA and reduced induction of PGP synthase after C(2)-ceramide addition compared with controls.
De novo biosynthesis of the late endosome lipid, bis(monoacylglycero)phosphate.
Kobayashi et al., Wako, Japan. In J Lipid Res, 2007
The biosynthesis of both PG and BMP was reduced significantly in the PGP synthase-deficient CHO mutants.
Stimulation of cardiac cardiolipin biosynthesis by PPARalpha activation.
Hatch et al., Winnipeg, Canada. In J Lipid Res, 2004
Cardiac PLA2, PGP synthase, and CDP-1,2-diacyl-sn-glycerol synthase (CDS-2) activities and CDS-2 mRNA levels were elevated in mice fed clofibrate for 14 days compared with controls.
Mitochondrial lipid alterations during Fas- and radiation-induced apoptosis.
Amoscato et al., Pittsburgh, United States. In Biochem Biophys Res Commun, 2001
The high basal levels of PG in Fas-resistant cells and the increase in PG levels in Fas-sensitive cells undergoing apoptosis was determined to be due to increased PGP synthase activity.
Purification of phosphatidylglycerophosphate synthase from Chinese hamster ovary cells.
Nishijima et al., Tokyo, Japan. In Biochem J, 2001
Recently we isolated a Chinese hamster ovary (CHO) PGS1 cDNA encoding PGP synthase.
Isolation of a chinese hamster ovary (CHO) cDNA encoding phosphatidylglycerophosphate (PGP) synthase, expression of which corrects the mitochondrial abnormalities of a PGP synthase-defective mutant of CHO-K1 cells.
Dowhan et al., Tokyo, Japan. In J Biol Chem, 1999
In this study, we isolated a Chinese hamster ovary (CHO) cDNA encoding a putative protein similar in sequence to the yeast PGS1 gene product, PGP synthase.
Phosphatidylglycerophosphate synthase from yeast.
Greenberg et al., United States. In Biochim Biophys Acta, 1997
PGP synthase from S. pombe (and cardiolipin synthase from S. cerevisiae) have been purified to homogeneity.
Stimulation of phosphatidylglycerolphosphate phosphatase activity by unsaturated fatty acids in rat heart.
Hatch et al., Winnipeg, Canada. In Lipids, 1994
Phosphatidylglycerolphosphate (PGP) synthase and PGP phosphatase catalyze the sequential synthesis of phosphatidylglycerol from cytidine-5'-diphosphate 1,2-diacyl-sn-glycerol (CDP-DG) and glycerol-3-phosphate. PGP synthase and PGP phosphatase activities were characterized in rat heart mitochondrial fractions, and the effect of fatty acids on the activity of these enzymes was determined.
A somatic cell mutant defective in phosphatidylglycerophosphate synthase, with impaired phosphatidylglycerol and cardiolipin biosynthesis.
Akamatsu et al., Tokyo, Japan. In J Biol Chem, 1993
We isolated a Chinese hamster ovary cell mutant (designated PGS-S) with a specific lesion in PGP synthase by using an in situ enzymatic assay for the enzyme.
Regulation of CDP-diacylglycerol synthesis and utilization by inositol and choline in Schizosaccharomyces pombe.
Greenberg et al., Ann Arbor, United States. In J Bacteriol, 1992
In complete synthetic medium containing inositol, maximal expression of CDP-DG synthase, PGP synthase, PI synthase, and PS synthase in wild-type cells occurred in the exponential phase of growth and decreased two- to fourfold in the stationary phase of growth.
Biochemical characterization and regulation of cardiolipin synthase in Saccharomyces cerevisiae.
Greenberg et al., Ann Arbor, United States. In Biochim Biophys Acta, 1990
Unlike many phospholipid biosynthetic enzymes including PGP synthase, which catalyzes the initial step in CL biosynthesis, CL synthase was not repressed in cells grown in the presence of the phospholipid precursor inositol.
Characterization and localization of phosphatidylglycerophosphate and phosphatidylserine synthases in Rhodobacter sphaeroides.
Niederman et al., United States. In Arch Microbiol, 1988
In preparations of cytoplasmic membrane (CM) enriched in these activities, apparent Km values of PGP synthase were 90 microM for sn-glycerol-3-phosphate and 60 microM for CDP-diacylglycerol; the apparent Km of PS synthase for L-serine was near 165 microM.
Phosphatidylglycerol biosynthesis in Bacillus licheniformis Resolution of membrane-bound enzymes by affinity chromatography on cytidinediphospho-sn-1,2-diacylglycerol Sepharose.
Dowhan et al., In Biochemistry, 1976
Both PGP synthase and PGP phosphatase of B. licheniformis were associated with a membrane component of the cell as evidenced by sucrose gradient centrifugation, differential centrifugation, and solubilization by buffers containing detergent...
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