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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 01 Sep 2015.

Ubiquitin carboxyl-terminal esterase L1

PGP 9.5, UCHL1
The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease.[provided by RefSeq, Sep 2009] (from NCBI)
Top mentioned proteins: Ubiquitin, HAD, CAN, AGE, S-100
Papers using PGP 9.5 antibodies
IFN-g production by alloantigen-reactive regulatory T cells is important for their regulatory function in vivo
Supplier
Zheng Song Guo, In PLoS ONE, 2004
... BD Biosciences), anti-CD14 (M5E2, BD Biosciences), anti-CD19 (HIB19, BD Biosciences), anti-CD40 (5C3, BD Biosciences), anti-CD45RO (UCHL1, BD Biosciences), anti-CD58 (AICD85, Immunotech), anti-CD80 ...
Evidence for the role of an altered redox state in hyporesponsiveness of synovial T cells in rheumatoid arthritis.
Supplier
Lipsky Peter E et al., In Arthritis Research, 1996
... gift of Dr G Trinchieri, The Wistar Institute, Philadelphia, PA, USA), anti-CD19 (Dako, Glostrup, Denmark), anti-CD45RO (UCHL1; Dako), and anti-CD45RA (2H4; gift ...
Increased cytolytic T lymphocyte activity and decreased B7 responsiveness are associated with CD28 down-regulation on CD8+T cells from HIV-infected subjects
Supplier
Lier René A.W. van et al., In The Journal of Experimental Medicine, 1994
... FITC-labeled CD45RO mAb (UCHL1) was purchased from DAKO (Glostrup, Denmark) ...
Papers on PGP 9.5
CpG methylation of ubiquitin carboxyl-terminal hydrolase 1 (UCHL1) and P53 mutation pattern in sporadic colorectal cancer.
New
Mokdad-Gargouri et al., Sfax, Tunisia. In Tumour Biol, 28 Sep 2015
In this study, we aimed to determine the CpG methylation pattern of the UCHL1 promoter, as well as the mutation spectrum and the expression pattern of P53 in sporadic colorectal cancer (CRC) from Tunisian patients.
Neonatal hypoxic ischemic encephalopathy-related biomarkers in serum and cerebrospinal fluid.
New
Li et al., Handan, China. In Clin Chim Acta, 27 Sep 2015
This study reviewed the mechanism of neonatal hypoxic ischemic encephalopathy in relation to numerous brain-related biomarkers including NSE, S-100β, GFAP, UCH-L1, Tau protein, miRNA, LDH, and CK-BB.
In vitro-conditioned bone marrow-derived mesenchymal stem cells (BMSC) promote de novo functional enteric nerve regeneration, but not through direct-transdifferentiation.
New
Li et al., Wuhan, China. In Stem Cells, 25 Sep 2015
A massive number of PGP9.5/NSE/HuC/D/Tuj1-positive (but GFP- and BBM-negative) neurons were effectively regenerated in denervated pylorus grafted with preconditioned BMSC, suggesting that they were regenerated de novo, not originating from trans-differentiation of the transplanted BMSC.
Overexpression of ubiquitin carboxyl terminal hydrolase-L1 enhances multidrug resistance and invasion/metastasis in breast cancer by activating the MAPK/Erk signaling pathway.
New
Liu et al., Shanghai, China. In Mol Carcinog, 21 Sep 2015
We aimed to clarify the mechanism underlying this observation and found that during the development of drug resistance to adriamycin in MCF7 cells, the elevated expression of UCH-L1 coincides with the up-regulation of MDR1, CD147, MMP2, and MMP9 as well as increased cellular migration/invasion.
LDOC1 silenced by cigarette exposure and involved in oral neoplastic transformation.
New
Lin et al., Taipei, Taiwan. In Oncotarget, 10 Aug 2015
By using integrated analysis of cDNA and methylation arrays of the smoking-associated dysplastic oral cell line and OSCC tumors, respectively, we identified four epigenetic targets-UCHL1, GPX3, LXN, and LDOC1-which may be silenced by cigarette.
Merkel cell carcinoma: is this a true carcinoma?
Review
New
Czajkowski et al., Bydgoszcz, Poland. In Exp Dermatol, Nov 2014
Expression of PGP 9.5, chromogranin A and several neuropeptides, initially regarded as specific markers for neural and neuroendocrine cells, has recently been shown in a subset of lymphomas.
Serum biomarkers to evaluate the integrity of the neurovascular unit.
Review
New
Chalak et al., Dallas, United States. In Early Hum Dev, Oct 2014
These biomarkers will be summarized in two categories: 1) Specific biomarkers targeting the neurovascular unit such as glial fibrillary acidic protein (GFAP), ubiquitin carboxyl-terminal hydrolase L1 (UCH-L1), S100B, and neuron specific enolase (NSE) and 2) general inflammatory cytokines, such as interleukin-6 (IL-6), interleukin-1b (IL-1b), and pNF-H, among others.
Ubiquitin carboxyl hydrolase L1 significance for human diseases.
Review
New
Thuoc et al., Thành phố Hồ Chí Minh, Vietnam. In Protein Pept Lett, Jul 2014
Ubiquitin carboxyl hydrolase L1 (UCH-L1) is an abundant multifunctional neuron protein.
Perspectives on molecular biomarkers of oxidative stress and antioxidant strategies in traumatic brain injury.
Review
Dafre et al., Florianópolis, Brazil. In Biomed Res Int, 2013
Traumatic brain injury (TBI) is frequently associated with abnormal blood-brain barrier function, resulting in the release of factors that can be used as molecular biomarkers of TBI, among them GFAP, UCH-L1, S100B, and NSE.
The degeneration and replacement of dopamine cells in Parkinson's disease: the role of aging.
Review
Sabate et al., Santa Cruz de Tenerife, Spain. In Front Neuroanat, 2013
Proteins involved in PD such as α-synuclein, UCH-L1, PINK1 or DJ-1, are also involved in aging.
Long non-coding antisense RNA controls Uchl1 translation through an embedded SINEB2 repeat.
Impact
Gustincich et al., Trieste, Italy. In Nature, 2012
Here we identify a nuclear-enriched lncRNA antisense to mouse ubiquitin carboxy-terminal hydrolase L1 (Uchl1), a gene involved in brain function and neurodegenerative diseases.
UCHL1 acts as a colorectal cancer oncogene via activation of the β-catenin/TCF pathway through its deubiquitinating activity.
GeneRIF
Huang et al., Beijing, China. In Int J Mol Med, 2012
UCHL1 may contribute to CRC progression by activating the beta-catenin/TCF pathway through its deubi-quitinating activity.
Recovery of hypothalamic tuberoinfundibular dopamine neurons from acute toxicant exposure is dependent upon protein synthesis and associated with an increase in parkin and ubiquitin carboxy-terminal hydrolase-L1 expression.
GeneRIF
Goudreau et al., East Lansing, United States. In Neurotoxicology, 2012
Recovery of hypothalamic tuberoinfundibular dopamine neurons from acute toxicant exposure is dependent upon protein synthesis and associated with an increase in parkin and ubiquitin carboxy-terminal hydrolase-L1 expression.
Mutation analysis of LRRK2, SCNA, UCHL1, HtrA2 and GIGYF2 genes in Chinese patients with autosomal dorminant Parkinson's disease.
GeneRIF
Tang et al., Changsha, China. In Neurosci Lett, 2012
Our result indicated that SCNA, LRRK2, UCHL1, HtrA2 and GIGYF2 genes' mutations might not be a main reason for Chinese Autosomal dorminant Parkinson's disease
Tumor suppressor function of PGP9.5 is associated with epigenetic regulation in prostate cancer--novel predictor of biochemical recurrence after radical surgery.
GeneRIF
Igawa et al., Izumo, Japan. In Cancer Epidemiol Biomarkers Prev, 2012
PGP9.5 downregulation of promoter CpG hypermethylation is associated with prostate cancer.
The ubiquitin peptidase UCHL1 induces G0/G1 cell cycle arrest and apoptosis through stabilizing p53 and is frequently silenced in breast cancer.
GeneRIF
Tao et al., Chongqing, China. In Plos One, 2011
Data suggest that UCHL1 promoter CpG methylation may serve as a potential tumor marker for breast cancer.
Occurrence of autoantibodies to annexin I, 14-3-3 theta and LAMR1 in prediagnostic lung cancer sera.
Impact
Hanash et al., Seattle, United States. In J Clin Oncol, 2008
The microarrays produced were used in a blinded validation study to determine whether annexin I, PGP9.5, and 14-3-3 theta antigens previously found to be targets of autoantibodies in newly diagnosed patients with lung cancer are associated with autoantibodies in sera collected at the presymptomatic stage and to determine whether additional antigens may be identified in prediagnostic sera.
Ubiquitin hydrolase Uch-L1 rescues beta-amyloid-induced decreases in synaptic function and contextual memory.
Impact
GeneRIF
Arancio et al., New York City, United States. In Cell, 2006
Results show that a component of the neuronal ubiquitin/proteasomal pathway, ubiquitin C-terminal hydrolase L1 (Uch-L1), is required for normal synaptic and cognitive function.
Improving synaptic function in a mouse model of AD.
Impact
Lansbury, Cambridge, United States. In Cell, 2006
The findings of Gong et al. (2006) now indicate that enhancing the activity of UCH-L1, a ubiquitin hydrolase, alleviates the synaptic dysfunction and memory loss associated with a mouse model of AD.
Pathogenetic mechanisms of parkin in Parkinson's disease.
Review
Impact
Mizuno et al., Tokyo, Japan. In Lancet, 2004
UCH-L1 is also an abundant deubiquitylating enzyme, and its mutation is linked to PARK5.
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