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Ubiquitin carboxyl-terminal esterase L1

PGP 9.5, UCHL1
The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease.[provided by RefSeq, Sep 2009] (from NCBI)
Top mentioned proteins: Ubiquitin, HAD, CAN, AGE, S-100
Papers using PGP 9.5 antibodies
IFN-g production by alloantigen-reactive regulatory T cells is important for their regulatory function in vivo
Zheng Song Guo, In PLoS ONE, 2004
... BD Biosciences), anti-CD14 (M5E2, BD Biosciences), anti-CD19 (HIB19, BD Biosciences), anti-CD40 (5C3, BD Biosciences), anti-CD45RO (UCHL1, BD Biosciences), anti-CD58 (AICD85, Immunotech), anti-CD80 ...
Evidence for the role of an altered redox state in hyporesponsiveness of synovial T cells in rheumatoid arthritis.
Lipsky Peter E et al., In Arthritis Research, 1996
... gift of Dr G Trinchieri, The Wistar Institute, Philadelphia, PA, USA), anti-CD19 (Dako, Glostrup, Denmark), anti-CD45RO (UCHL1; Dako), and anti-CD45RA (2H4; gift ...
Increased cytolytic T lymphocyte activity and decreased B7 responsiveness are associated with CD28 down-regulation on CD8+T cells from HIV-infected subjects
Lier René A.W. van et al., In The Journal of Experimental Medicine, 1994
... FITC-labeled CD45RO mAb (UCHL1) was purchased from DAKO (Glostrup, Denmark) ...
Papers on PGP 9.5
Ubiquitin C-terminal hydrolase L1 deletion ameliorates glomerular injury in mice with ACTN4-associated focal segmental glomerulosclerosis.
Kennedy et al., Ottawa, Canada. In Biochim Biophys Acta, Jul 2014
Renal ubiquitin C-terminal hydrolase L1 (UCHL1) is upregulated in a subset of human glomerulopathies, including focal segmental glomerulosclerosis (FSGS), where it may serve to promote ubiquitin pools for degradation of cytotoxic proteins.
Distribution of IL-31 and its receptor expressing cells in skin of atopic dermatitis.
Morita et al., Gotemba, Japan. In J Dermatol Sci, Jun 2014
IL-31RA was stained immunohistochemically in AD skins and normal human DRG, and representative AD skins were double stained with IL-31RA and PGP9.5 (a nerve marker).
Allele-specific silencing of mutant Ataxin-7 in SCA7 patient-derived fibroblasts.
Wood et al., Oxford, United Kingdom. In Eur J Hum Genet, Apr 2014
We further identified altered expression of two disease-relevant transcripts in SCA7 patient cells: a twofold increase in levels of the HSP DNAJA1 and a twofold decrease in levels of the de-ubiquitinating enzyme, UCHL1.
Multiple polymerase chain reaction markers for the differentiation of canine cutaneous peripheral nerve sheath tumours versus canine fibrosarcomas.
Klopfleisch et al., Berlin, Germany. In J Comp Pathol, Feb 2014
Fifty histologically well-defined examples of canine fibrosarcomas and PNSTs were characterized immunohistochemically for the expression of S100, laminin and PGP 9.5.
Could dysregulation of UPS be a common underlying mechanism for cancer and neurodegeneration? Lessons from UCHL1.
Özdinler et al., Chicago, United States. In Cell Biochem Biophys, Sep 2013
This review will focus on ubiquitin carboxy-terminal hydrolase L1 (UCHL1), a DUB that is attributed to both cancer and neurodegeneration.
Biomarkers for the clinical differential diagnosis in traumatic brain injury--a systematic review.
Bullock et al., Miami, United States. In Cns Neurosci Ther, Aug 2013
Presently, neurofilament (NF), S100β, glial fibrillary acidic protein (GFAP), and ubiquitin carboxyl terminal hydrolase-L1 (UCH-L1) seemed to have the best potential as diagnostic biomarkers for distinguishing focal and diffuse injury, whereas C-tau, neuron-specific enolase (NSE), S100β, GFAP, and spectrin breakdown products (SBDPs) appear to be candidates for ICP reflective biomarkers.
The importance of endometrial nerve fibers and macrophage cell count in the diagnosis of endometriosis.
Tuzlali et al., İstanbul, Turkey. In Iran J Reprod Med, May 2013
Endometrial samples were evaluated immunohistochemically with the markers protein gene product 9.5 (PGP 9.5) and neurofilament (NF) for nerve fibers and CD68 for macrophages.
Monogenic Parkinson's disease and parkinsonism: clinical phenotypes and frequencies of known mutations.
Puschmann, Lund, Sweden. In Parkinsonism Relat Disord, Apr 2013
Changes in a long list of additional genes have been suggested as causes for parkinsonism or PD, including genes for hereditary ataxias (ATXN2, ATXN3, FMR1), frontotemporal dementia (C9ORF72, GRN, MAPT, TARDBP), DYT5 (GCH1, TH, SPR), and others (ATP13A2, CSF1R, DNAJC6, FBXO, GIGYF2, HTRA2, PLA2G6, POLG, SPG11, UCHL1).
Agrochemicals, α-synuclein, and Parkinson's disease.
Uversky et al., Santa Cruz, United States. In Mol Neurobiol, Apr 2013
The role of genetic predisposition in PD has also been increasingly acknowledged, driven by the identification of a number of disease-related genes [e.g., α-synuclein, parkin, DJ-1, ubiquitin C-terminal hydrolase isozyme L1 (UCH-L1), and nuclear receptor-related factor 1]. Therefore, the etiology of this multifactorial disease is likely to involve both genetic and environmental factors.
Long non-coding antisense RNA controls Uchl1 translation through an embedded SINEB2 repeat.
Gustincich et al., Trieste, Italy. In Nature, 2012
Here we identify a nuclear-enriched lncRNA antisense to mouse ubiquitin carboxy-terminal hydrolase L1 (Uchl1), a gene involved in brain function and neurodegenerative diseases.
Psychotropic drug effects on gene transcriptomics relevant to Parkinson's disease.
Lauterbach, Macon, United States. In Prog Neuropsychopharmacol Biol Psychiatry, 2012
RESULTS: Psychotropic drugs can meaningfully affect PD risk gene mRNA transcription, including antipsychotics (upregulate dopamine receptors D2 and D3 (DRD2, DRD3); downregulate low-density lipoprotein receptor-related protein 8 (LRP8), ubiquitin carboxyl-terminal esterase L1 (UCHL1, also known as PARK5)), haloperidol (upregulates DRD3, parkin (PRKN, also known as PARK2), DRD2; downregulates brain-derived neurotrophic factor (BDNF)), risperidone (upregulates monoamine oxidase B (MAOB), DRD2), olanzapine (upregulates transmembrane protein 163 (TMEM163), BDNF, glutathione S-transferase mu 1 (GSTM1), MAOB, DRD2, solute carrier organic anion transporter family, member 3A1 (SLCO3A1)), aripiprazole (upregulates DRD2), quetiapine, paliperidone, lurasidone, carbamazepine, and many antidepressants (upregulate BDNF), lithium and bupropion (downregulate BDNF), amitriptyline (upregulates DRD3, DRD2), imipramine (upregulates BDNF, DRD3, DRD2), desipramine (upregulates BDNF, DRD3), and fluoxetine (upregulates acid beta-glucosidase (GBA), coiled-coil domain containing 62 (CCDC62), BDNF, DRD3, UCHL1, unc-13 homolog B (UNC13B), and perhaps huntingtin interacting protein 1 related (HIP1R); downregulates microtubule-associated protein tau (MAPT), methylcrotonoyl-coenzyme A carboxylase I (MCCC1), GSTM1, 28kDa calbindin 1 (CALB1)).
UCHL1 acts as a colorectal cancer oncogene via activation of the β-catenin/TCF pathway through its deubiquitinating activity.
Huang et al., Beijing, China. In Int J Mol Med, 2012
UCHL1 may contribute to CRC progression by activating the beta-catenin/TCF pathway through its deubi-quitinating activity.
Recovery of hypothalamic tuberoinfundibular dopamine neurons from acute toxicant exposure is dependent upon protein synthesis and associated with an increase in parkin and ubiquitin carboxy-terminal hydrolase-L1 expression.
Goudreau et al., East Lansing, United States. In Neurotoxicology, 2012
Recovery of hypothalamic tuberoinfundibular dopamine neurons from acute toxicant exposure is dependent upon protein synthesis and associated with an increase in parkin and ubiquitin carboxy-terminal hydrolase-L1 expression.
Mutation analysis of LRRK2, SCNA, UCHL1, HtrA2 and GIGYF2 genes in Chinese patients with autosomal dorminant Parkinson's disease.
Tang et al., Changsha, China. In Neurosci Lett, 2012
Our result indicated that SCNA, LRRK2, UCHL1, HtrA2 and GIGYF2 genes' mutations might not be a main reason for Chinese Autosomal dorminant Parkinson's disease
Tumor suppressor function of PGP9.5 is associated with epigenetic regulation in prostate cancer--novel predictor of biochemical recurrence after radical surgery.
Igawa et al., Izumo, Japan. In Cancer Epidemiol Biomarkers Prev, 2012
PGP9.5 downregulation of promoter CpG hypermethylation is associated with prostate cancer.
The ubiquitin peptidase UCHL1 induces G0/G1 cell cycle arrest and apoptosis through stabilizing p53 and is frequently silenced in breast cancer.
Tao et al., Chongqing, China. In Plos One, 2011
Data suggest that UCHL1 promoter CpG methylation may serve as a potential tumor marker for breast cancer.
Occurrence of autoantibodies to annexin I, 14-3-3 theta and LAMR1 in prediagnostic lung cancer sera.
Hanash et al., Seattle, United States. In J Clin Oncol, 2008
The microarrays produced were used in a blinded validation study to determine whether annexin I, PGP9.5, and 14-3-3 theta antigens previously found to be targets of autoantibodies in newly diagnosed patients with lung cancer are associated with autoantibodies in sera collected at the presymptomatic stage and to determine whether additional antigens may be identified in prediagnostic sera.
Ubiquitin hydrolase Uch-L1 rescues beta-amyloid-induced decreases in synaptic function and contextual memory.
Arancio et al., New York City, United States. In Cell, 2006
Results show that a component of the neuronal ubiquitin/proteasomal pathway, ubiquitin C-terminal hydrolase L1 (Uch-L1), is required for normal synaptic and cognitive function.
Improving synaptic function in a mouse model of AD.
Lansbury, Cambridge, United States. In Cell, 2006
The findings of Gong et al. (2006) now indicate that enhancing the activity of UCH-L1, a ubiquitin hydrolase, alleviates the synaptic dysfunction and memory loss associated with a mouse model of AD.
Pathogenetic mechanisms of parkin in Parkinson's disease.
Mizuno et al., Tokyo, Japan. In Lancet, 2004
UCH-L1 is also an abundant deubiquitylating enzyme, and its mutation is linked to PARK5.
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