IFN-g production by alloantigen-reactive regulatory T cells is important for their regulatory function in vivo
In PLoS ONE, 2004
... BD Biosciences), anti-CD14 (M5E2, BD Biosciences), anti-CD19 (HIB19, BD Biosciences), anti-CD40 (5C3, BD Biosciences), anti-CD45RO (UCHL1, BD Biosciences), anti-CD58 (AICD85, Immunotech), anti-CD80 ... Evidence for the role of an altered redox state in hyporesponsiveness of synovial T cells in rheumatoid arthritis.
In Arthritis Research, 1996
... gift of Dr G Trinchieri, The Wistar Institute, Philadelphia, PA, USA), anti-CD19 (Dako, Glostrup, Denmark), anti-CD45RO (UCHL1; Dako), and anti-CD45RA (2H4; gift ...
337 promoter-dependent silencing of reprogramming transcription factors in mouse induced pluripotent stem cells produced with sleeping beauty transposon vectors.
Neustadt, Germany. In Reprod Fertil Dev, 31 Dec 2014
Moreover, these cells also showed ability to differentiate in vitro into cells from the 3 germ layers (contracting cardiac myocytes, neurons, epithelia) expressing differentiation markers Afp, Sox17, Gata4, Gata6, cardiac troponin, nestin, and PGP 9.5.
324 TESTIS-SPECIFIC EXPRESSION OF Oct4-EGFP TRANSGENE IN PIG.
Germany. In Reprod Fertil Dev, 31 Dec 2014
Analysis of isolated EGFP positive cells with qRT-PCR demonstrated the presence of marker genes specific for undifferentiated (Oct4, UTF1, FGFR3, PGP 9.5, THY-1, SALL4, and GFRα1) and differentiated (BOLL and PRM2) germ cells.
Protective and toxic roles of dopamine in Parkinson's disease.
Santiago, Chile. In J Neurochem, Jun 2014
The discovery of genes associated with Parkinson's disease (such as alpha synuclein (SNCA), E3 ubiquitin protein ligase (parkin), DJ-1 (PARK7), ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCHL-1), serine/threonine-protein kinase (PINK-1), leucine-rich repeat kinase 2 (LRRK2), cation-transporting ATPase 13A1 (ATP13A), etc.) contributed enormously to basic research towards understanding the role of these proteins in the sporadic form of the disease.
[Study of Parkinson's disease based on Drosophila model].
Hangzhou, China. In Zhejiang Da Xue Xue Bao Yi Xue Ban, Nov 2013
Thirteen familial PD related loci have been identified, including six mutations:α-SYN(PARK1/4), Parkin(PARK2), UCHL1(PARK5), PINK1(PARK6), DJ-1(PARK7) and LRRK2 (PARK8).
Biomarkers for the clinical differential diagnosis in traumatic brain injury--a systematic review.
Miami, United States. In Cns Neurosci Ther, Aug 2013
Presently, neurofilament (NF), S100β, glial fibrillary acidic protein (GFAP), and ubiquitin carboxyl terminal hydrolase-L1 (UCH-L1) seemed to have the best potential as diagnostic biomarkers for distinguishing focal and diffuse injury, whereas C-tau, neuron-specific enolase (NSE), S100β, GFAP, and spectrin breakdown products (SBDPs) appear to be candidates for ICP reflective biomarkers.
Occurrence of autoantibodies to annexin I, 14-3-3 theta and LAMR1 in prediagnostic lung cancer sera.
Seattle, United States. In J Clin Oncol, 2008
The microarrays produced were used in a blinded validation study to determine whether annexin I, PGP9.5, and 14-3-3 theta antigens previously found to be targets of autoantibodies in newly diagnosed patients with lung cancer are associated with autoantibodies in sera collected at the presymptomatic stage and to determine whether additional antigens may be identified in prediagnostic sera.
Improving synaptic function in a mouse model of AD.
Cambridge, United States. In Cell, 2006
The findings of Gong et al. (2006) now indicate that enhancing the activity of UCH-L1, a ubiquitin hydrolase, alleviates the synaptic dysfunction and memory loss associated with a mouse model of AD.