gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 30 Mar 2015.

Ubiquitin carboxyl-terminal esterase L1

PGP 9.5, UCHL1
The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease.[provided by RefSeq, Sep 2009] (from NCBI)
Top mentioned proteins: Ubiquitin, HAD, CAN, AGE, S-100
Papers using PGP 9.5 antibodies
IFN-g production by alloantigen-reactive regulatory T cells is important for their regulatory function in vivo
Supplier
Zheng Song Guo, In PLoS ONE, 2004
... BD Biosciences), anti-CD14 (M5E2, BD Biosciences), anti-CD19 (HIB19, BD Biosciences), anti-CD40 (5C3, BD Biosciences), anti-CD45RO (UCHL1, BD Biosciences), anti-CD58 (AICD85, Immunotech), anti-CD80 ...
Evidence for the role of an altered redox state in hyporesponsiveness of synovial T cells in rheumatoid arthritis.
Supplier
Lipsky Peter E et al., In Arthritis Research, 1996
... gift of Dr G Trinchieri, The Wistar Institute, Philadelphia, PA, USA), anti-CD19 (Dako, Glostrup, Denmark), anti-CD45RO (UCHL1; Dako), and anti-CD45RA (2H4; gift ...
Increased cytolytic T lymphocyte activity and decreased B7 responsiveness are associated with CD28 down-regulation on CD8+T cells from HIV-infected subjects
Supplier
Lier René A.W. van et al., In The Journal of Experimental Medicine, 1994
... FITC-labeled CD45RO mAb (UCHL1) was purchased from DAKO (Glostrup, Denmark) ...
Papers on PGP 9.5
Serum GFAP predicts tissue GFAP break down products and therapeutic efficacy after penetrating ballistic-like brain injury.
New
Schmid et al., Silver Spring, United States. In J Neurotrauma, 19 Apr 2015
Penetrating ballistic-like brain injury (PBBI) was used to systematically analyze several key TBI biomarkers (GFAP and its BDPs, UCH-L1, α-II spectrin, SBDPs) in brain tissues and serum during an extended acute-subacute time frame.
Acute Temporal Profiles of serum levels of UCH-L1 and GFAP and Relationships to Neuronal and Astroglial Pathology Following Traumatic Brain Injury in Rats.
New
Lyeth et al., Davis, United States. In J Neurotrauma, 12 Apr 2015
Serum and CSF samples were analyzed for neuronal (Ubiquitin carboxy-terminal hydrolase L1 [UCH-L1]) and astroglial (glial fibrillary acidic protein [GFAP]) protein levels using ELISA.
Association of ubiquitin carboxy-terminal hydrolase-L1 in cerebrospinal fluid with clinical severity in a cohort of patients with Guillain-Barré syndrome.
New
Kabuta et al., Fuchū, Japan. In Neurol Sci, 05 Apr 2015
In this paper, we investigated whether the amount of the neuron-specific protein, ubiquitin carboxy-terminal hydrolase-L1 (UCH-L1), in the cerebrospinal fluid of patients with GBS was correlated with the clinical course of the disease.
Differential Role of the Proteasome in the Early and Late Phases of BDNF-Induced Facilitation of LTP.
New
Duarte et al., Lisbon, Portugal. In J Neurosci, 25 Mar 2015
Furthermore, BDNF increased the activity of the deubiquitinating enzyme UchL1 in synaptoneurosomes and upregulated free ubiquitin.
Paraganglioma of the urinary bladder: a challenging diagnosis in transurethral resection specimens: a case report.
New
Toncini et al., In Anal Quant Cytopathol Histpathol, Oct 2014
On immunohistochemical staining, the tumor cells were negative for epithelial membrane antigen, cytokeratin 7, and carcinoembryonic antigen and positive for chromogranin A, NSE, and PGP9.5.
Ubiquitin carboxyl hydrolase L1 significance for human diseases.
Review
New
Thuoc et al., Thành phố Hồ Chí Minh, Vietnam. In Protein Pept Lett, Jul 2014
Ubiquitin carboxyl hydrolase L1 (UCH-L1) is an abundant multifunctional neuron protein.
Protective and toxic roles of dopamine in Parkinson's disease.
Review
New
Zucca et al., Santiago, Chile. In J Neurochem, Jun 2014
The discovery of genes associated with Parkinson's disease (such as alpha synuclein (SNCA), E3 ubiquitin protein ligase (parkin), DJ-1 (PARK7), ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCHL-1), serine/threonine-protein kinase (PINK-1), leucine-rich repeat kinase 2 (LRRK2), cation-transporting ATPase 13A1 (ATP13A), etc.) contributed enormously to basic research towards understanding the role of these proteins in the sporadic form of the disease.
Brain injury biomarkers as outcome predictors in pediatric severe traumatic brain injury.
Review
New
Fraser et al., London, Canada. In Neurocrit Care, Jun 2014
Significant correlations were established between sTBI outcomes and various biomarkers in CSF (IL-6, IL-8, IL-1β, S100β, NGF, NSE, DCX, ET-1, HMGB-1, cytochrome C) and blood (GFAP, NF-H, UCH-L1, SBDP-145, leptin).
The degeneration and replacement of dopamine cells in Parkinson's disease: the role of aging.
Review
Sabate et al., Santa Cruz de Tenerife, Spain. In Front Neuroanat, 2013
Proteins involved in PD such as α-synuclein, UCH-L1, PINK1 or DJ-1, are also involved in aging.
[Study of Parkinson's disease based on Drosophila model].
Review
Jin et al., Hangzhou, China. In Zhejiang Da Xue Xue Bao Yi Xue Ban, 2013
Thirteen familial PD related loci have been identified, including six mutations:α-SYN(PARK1/4), Parkin(PARK2), UCHL1(PARK5), PINK1(PARK6), DJ-1(PARK7) and LRRK2 (PARK8).
Long non-coding antisense RNA controls Uchl1 translation through an embedded SINEB2 repeat.
Impact
Gustincich et al., Trieste, Italy. In Nature, 2012
Here we identify a nuclear-enriched lncRNA antisense to mouse ubiquitin carboxy-terminal hydrolase L1 (Uchl1), a gene involved in brain function and neurodegenerative diseases.
UCHL1 acts as a colorectal cancer oncogene via activation of the β-catenin/TCF pathway through its deubiquitinating activity.
GeneRIF
Huang et al., Beijing, China. In Int J Mol Med, 2012
UCHL1 may contribute to CRC progression by activating the beta-catenin/TCF pathway through its deubi-quitinating activity.
Recovery of hypothalamic tuberoinfundibular dopamine neurons from acute toxicant exposure is dependent upon protein synthesis and associated with an increase in parkin and ubiquitin carboxy-terminal hydrolase-L1 expression.
GeneRIF
Goudreau et al., East Lansing, United States. In Neurotoxicology, 2012
Recovery of hypothalamic tuberoinfundibular dopamine neurons from acute toxicant exposure is dependent upon protein synthesis and associated with an increase in parkin and ubiquitin carboxy-terminal hydrolase-L1 expression.
Mutation analysis of LRRK2, SCNA, UCHL1, HtrA2 and GIGYF2 genes in Chinese patients with autosomal dorminant Parkinson's disease.
GeneRIF
Tang et al., Changsha, China. In Neurosci Lett, 2012
Our result indicated that SCNA, LRRK2, UCHL1, HtrA2 and GIGYF2 genes' mutations might not be a main reason for Chinese Autosomal dorminant Parkinson's disease
Tumor suppressor function of PGP9.5 is associated with epigenetic regulation in prostate cancer--novel predictor of biochemical recurrence after radical surgery.
GeneRIF
Igawa et al., Izumo, Japan. In Cancer Epidemiol Biomarkers Prev, 2012
PGP9.5 downregulation of promoter CpG hypermethylation is associated with prostate cancer.
The ubiquitin peptidase UCHL1 induces G0/G1 cell cycle arrest and apoptosis through stabilizing p53 and is frequently silenced in breast cancer.
GeneRIF
Tao et al., Chongqing, China. In Plos One, 2011
Data suggest that UCHL1 promoter CpG methylation may serve as a potential tumor marker for breast cancer.
Occurrence of autoantibodies to annexin I, 14-3-3 theta and LAMR1 in prediagnostic lung cancer sera.
Impact
Hanash et al., Seattle, United States. In J Clin Oncol, 2008
The microarrays produced were used in a blinded validation study to determine whether annexin I, PGP9.5, and 14-3-3 theta antigens previously found to be targets of autoantibodies in newly diagnosed patients with lung cancer are associated with autoantibodies in sera collected at the presymptomatic stage and to determine whether additional antigens may be identified in prediagnostic sera.
Ubiquitin hydrolase Uch-L1 rescues beta-amyloid-induced decreases in synaptic function and contextual memory.
Impact
GeneRIF
Arancio et al., New York City, United States. In Cell, 2006
Results show that a component of the neuronal ubiquitin/proteasomal pathway, ubiquitin C-terminal hydrolase L1 (Uch-L1), is required for normal synaptic and cognitive function.
Improving synaptic function in a mouse model of AD.
Impact
Lansbury, Cambridge, United States. In Cell, 2006
The findings of Gong et al. (2006) now indicate that enhancing the activity of UCH-L1, a ubiquitin hydrolase, alleviates the synaptic dysfunction and memory loss associated with a mouse model of AD.
Pathogenetic mechanisms of parkin in Parkinson's disease.
Review
Impact
Mizuno et al., Tokyo, Japan. In Lancet, 2004
UCH-L1 is also an abundant deubiquitylating enzyme, and its mutation is linked to PARK5.
share on facebooktweetadd +1mail to friends