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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 25 Jan 2016.

Ubiquitin carboxyl-terminal esterase L1

PGP 9.5, UCHL1
The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease.[provided by RefSeq, Sep 2009] (from NCBI)
Top mentioned proteins: Ubiquitin, HAD, CAN, AGE, S-100
Papers using PGP 9.5 antibodies
IFN-g production by alloantigen-reactive regulatory T cells is important for their regulatory function in vivo
Supplier
Zheng Song Guo, In PLoS ONE, 2004
... BD Biosciences), anti-CD14 (M5E2, BD Biosciences), anti-CD19 (HIB19, BD Biosciences), anti-CD40 (5C3, BD Biosciences), anti-CD45RO (UCHL1, BD Biosciences), anti-CD58 (AICD85, Immunotech), anti-CD80 ...
Evidence for the role of an altered redox state in hyporesponsiveness of synovial T cells in rheumatoid arthritis.
Supplier
Lipsky Peter E et al., In Arthritis Research, 1996
... gift of Dr G Trinchieri, The Wistar Institute, Philadelphia, PA, USA), anti-CD19 (Dako, Glostrup, Denmark), anti-CD45RO (UCHL1; Dako), and anti-CD45RA (2H4; gift ...
Increased cytolytic T lymphocyte activity and decreased B7 responsiveness are associated with CD28 down-regulation on CD8+T cells from HIV-infected subjects
Supplier
Lier René A.W. van et al., In The Journal of Experimental Medicine, 1994
... FITC-labeled CD45RO mAb (UCHL1) was purchased from DAKO (Glostrup, Denmark) ...
Papers on PGP 9.5
Effects of inhibition of ubiquitin C-terminal hydrolase L1 (UCH-L1) on sperm incorporation and cortical tension in mouse eggs.
New
Evans et al., Baltimore, United States. In Mol Reprod Dev, 19 Feb 2016
UNASSIGNED: Ubiquitin C-Terminal Hydrolase L1 (UCH-L1) is thought to have multiple functions in mammalian oocytes and early embryos (e.g., Mtango et al. 2011; Sekiguchi et al. 2006); indeed, UCH-L1 is enriched in the egg cortex (Sekiguchi et al. 2006).
Gut-derived cholecystokinin contributes to visceral hypersensitivity via nerve growth factor-dependent neurite outgrowth.
New
Yu et al., Taipei, Taiwan. In J Gastroenterol Hepatol, 15 Feb 2016
Nerve fibers in intestinal tissues were stained using immunohistochemistry (PGP9.5).
Monitoring of beta cell replacement outcomes.
New
Naziruddin et al., Waco, United States. In Panminerva Med, 13 Feb 2016
Several islet-specific proteins such as GAD-65, DCX, PPP1R1A, UCHL1, and HMGB1 have been proposed as candidates to monitor islet damage, but these biomarkers have short half-lives and unreliable detection.
Absence of alsin function leads to corticospinal motor neuron vulnerability via novel disease mechanisms.
New
Özdinler et al., Chicago, United States. In Hum Mol Genet, 10 Feb 2016
In an effort to visualize CSMN in vivo and to investigate precise aspects of neuronal abnormalities in the absence of alsin function, we generated Alsin(KO)-UeGFP mice, by crossing Alsin(KO) and UCHL1-eGFP mice, a CSMN reporter line.
Pathophysiology of Pruritus in Primary Localised Cutaneous Amyloidosis.
New
Yosipovitch et al., Singapore, Singapore. In Br J Dermatol, 08 Feb 2016
Patients' biopsies revealed lower IENF counts (p<0.001 using PGP9.5, ΒIII-tubulin and Neurofilament-200 stains) and increased epidermal expression of OSMRβ (p<0.001) and IL-31RA (p=0.002).
Nerve Bundles and Deep Dyspareunia in Endometriosis.
New
Yong et al., Vancouver, Canada. In Reprod Sci, 27 Jan 2016
Protein gene product 9.5 (PGP9.5)
UCH-L1 is induced in germinal center B-cells and identifies patients with aggressive germinal center diffuse large B-cell lymphoma.
New
Galardy et al., Rochester, United States. In Blood, 23 Jan 2016
We previously found that the ubiquitin hydrolase UCH-L1 is frequently overexpressed in mature B-cell malignancies and is a potent oncogene in mice.
Insight into Preclinical Models of Traumatic Brain Injury Using Circulating Brain Damage Biomarkers: Operation Brain Trauma Therapy.
New
Kochanek et al., Messina, Italy. In J Neurotrauma, 16 Jan 2016
The glial marker glial fibrillary acidic protein (GFAP) and the neuronal marker ubiquitin C-terminal hydrolase (UCH-L1) were measured by ELISA in blood at 4 and 24 h and their delta 24-4 h was calculated for each marker.
Levetiracetam Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy.
New
Kochanek et al., Pittsburgh, United States. In J Neurotrauma, 16 Jan 2016
No treatment effects were seen for UCH-L1 across models.
UCH-L1 involved in regulating the degradation of EGFR and promoting malignant properties in drug-resistant breast cancer.
Zou et al., Shanghai, China. In Int J Clin Exp Pathol, 2014
Ubiquitin carboxy terminal hydrolase-L1 (UCHL1) belongs to the UCH proteases family that deubiquitinates ubiquitin-protein conjugates in the ubiquitin-proteasome system.
Long non-coding antisense RNA controls Uchl1 translation through an embedded SINEB2 repeat.
Impact
Gustincich et al., Trieste, Italy. In Nature, 2012
Here we identify a nuclear-enriched lncRNA antisense to mouse ubiquitin carboxy-terminal hydrolase L1 (Uchl1), a gene involved in brain function and neurodegenerative diseases.
UCHL1 acts as a colorectal cancer oncogene via activation of the β-catenin/TCF pathway through its deubiquitinating activity.
GeneRIF
Huang et al., Beijing, China. In Int J Mol Med, 2012
UCHL1 may contribute to CRC progression by activating the beta-catenin/TCF pathway through its deubi-quitinating activity.
Recovery of hypothalamic tuberoinfundibular dopamine neurons from acute toxicant exposure is dependent upon protein synthesis and associated with an increase in parkin and ubiquitin carboxy-terminal hydrolase-L1 expression.
GeneRIF
Goudreau et al., East Lansing, United States. In Neurotoxicology, 2012
Recovery of hypothalamic tuberoinfundibular dopamine neurons from acute toxicant exposure is dependent upon protein synthesis and associated with an increase in parkin and ubiquitin carboxy-terminal hydrolase-L1 expression.
Mutation analysis of LRRK2, SCNA, UCHL1, HtrA2 and GIGYF2 genes in Chinese patients with autosomal dorminant Parkinson's disease.
GeneRIF
Tang et al., Changsha, China. In Neurosci Lett, 2012
Our result indicated that SCNA, LRRK2, UCHL1, HtrA2 and GIGYF2 genes' mutations might not be a main reason for Chinese Autosomal dorminant Parkinson's disease
Tumor suppressor function of PGP9.5 is associated with epigenetic regulation in prostate cancer--novel predictor of biochemical recurrence after radical surgery.
GeneRIF
Igawa et al., Izumo, Japan. In Cancer Epidemiol Biomarkers Prev, 2012
PGP9.5 downregulation of promoter CpG hypermethylation is associated with prostate cancer.
The ubiquitin peptidase UCHL1 induces G0/G1 cell cycle arrest and apoptosis through stabilizing p53 and is frequently silenced in breast cancer.
GeneRIF
Tao et al., Chongqing, China. In Plos One, 2011
Data suggest that UCHL1 promoter CpG methylation may serve as a potential tumor marker for breast cancer.
Occurrence of autoantibodies to annexin I, 14-3-3 theta and LAMR1 in prediagnostic lung cancer sera.
Impact
Hanash et al., Seattle, United States. In J Clin Oncol, 2008
The microarrays produced were used in a blinded validation study to determine whether annexin I, PGP9.5, and 14-3-3 theta antigens previously found to be targets of autoantibodies in newly diagnosed patients with lung cancer are associated with autoantibodies in sera collected at the presymptomatic stage and to determine whether additional antigens may be identified in prediagnostic sera.
Ubiquitin hydrolase Uch-L1 rescues beta-amyloid-induced decreases in synaptic function and contextual memory.
Impact
GeneRIF
Arancio et al., New York City, United States. In Cell, 2006
Results show that a component of the neuronal ubiquitin/proteasomal pathway, ubiquitin C-terminal hydrolase L1 (Uch-L1), is required for normal synaptic and cognitive function.
Improving synaptic function in a mouse model of AD.
Impact
Lansbury, Cambridge, United States. In Cell, 2006
The findings of Gong et al. (2006) now indicate that enhancing the activity of UCH-L1, a ubiquitin hydrolase, alleviates the synaptic dysfunction and memory loss associated with a mouse model of AD.
Pathogenetic mechanisms of parkin in Parkinson's disease.
Impact
Mizuno et al., Tokyo, Japan. In Lancet, 2004
UCH-L1 is also an abundant deubiquitylating enzyme, and its mutation is linked to PARK5.
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