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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Prostaglandin D2 synthase 21kDa

The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. This gene is preferentially expressed in brain. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement sleep. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, ACID, Cx26, V1a
Papers using PGD2 antibodies
Developmental differences in the immortalization of lung fibroblasts by telomerase
Bonner William M et al., In Epigenetics & Chromatin, 2002
... Cells were fixed at the indicated population doublings (PDs) and SA-β-gal staining was performed following the manufacturer's instructions (Cell Signaling Technology, Danvers, MA, US) ...
Peroxisome proliferator-activated receptor-gamma agonists inhibit experimental allergic encephalomyelitis by blocking IL-12 production, IL-12 signaling and Th1 differentiation
Reeves Steven A et al., In Journal of Neuroinflammation, 2001
... were from Invitrogen (Carlsbad, CA); SYBR green PCR mix was from Amersham (Piscataway, NJ); 15d-PGJ2, PGD2, PGE2, PGF2α, T0070907, AH6809, BAY-u3405 and GSH kit were from Cayman Chemicals (Ann Arbor, MI); ...
Papers on PGD2
Deafness gene mutations in newborns in Beijing.
Ni et al., Beijing, China. In Acta Otolaryngol, Feb 2016
Study sample This study tested 37 573 newborns within 3 days after birth, including nine sites in four genes: GJB2 (35 del G, 176 del 16, 235 del C, 299 del AT), SLC26A4 (IVS7-2 A > G, 2168 A > G), MTRNR1 (1555 A > G, 1494 C > T), and GJB3 (538 C > T).
An effective screening strategy for deafness in combination with a next-generation sequencing platform: a consecutive analysis.
Usami et al., Yokohama, Japan. In J Hum Genet, Feb 2016
We used the Invader assay for 46 mutations in 13 genes and Sanger sequencing for the GJB2 gene or SLC26A4 gene in the first-stage test, the TaqMan genotyping assay in the second-stage test and targeted exon sequencing using massively parallel DNA sequencing in the third-stage test.
Resveratrol preferentially inhibits IgE-dependent PGD2 biosynthesis but enhances TNF production from human skin mast cells.
Gomez et al., Columbia, United States. In Biochim Biophys Acta, Feb 2016
RESULTS: Resveratrol at low concentrations (≤ 10μM) inhibited PGD2 biosynthesis but not degranulation.
Genetic counseling for patients with nonsyndromic hearing impairment directed by gene analysis.
Xu et al., Nanjing, China. In Mol Med Report, Feb 2016
Previous molecular etiological studies have demonstrated that the most common molecular changes in Chinese patients with nonsyndromic hearing loss (NSHL) involved gap junction protein β 2, solute carrier family 26, member 4 (SLC26A4), and mitochondrial DNA 12S rRNA.
The hippocampus participates in a pharmacological rat model of absence seizures.
Stan Leung et al., London, Canada. In Epilepsy Res, Jan 2016
OBJECTIVE: Using the gamma-butyrolactone (GBL) model of absence seizures in Long-Evans rats, this study investigated if 2.5-6Hz paroxysmal discharges (PDs) induced by GBL were synchronized among the thalamocortical system and the hippocampus, and whether inactivation of the hippocampus affected PDs.
Genetics of Hearing Loss-Nonsyndromic.
Chang, Stanford, United States. In Otolaryngol Clin North Am, Dec 2015
Although AR nonsyndromic SNHL is most commonly caused by GJB2 and SLC26A4, there is no single gene that accounts for any significant proportion of AD SNHL.
Diagnostic Value of SLC26A4 Mutation Status in Hereditary Hearing Loss With EVA: A PRISMA-Compliant Meta-Analysis.
Cao et al., Nanjing, China. In Medicine (baltimore), Dec 2015
Many SLC26A4 mutations have been identified in patients with nonsyndromic enlarged vestibular aqueduct (EVA).
Vascular endothelial growth factor A: just one of multiple mechanisms for sex-specific vascular development within the testis?
Cupp et al., Lincoln, United States. In J Endocrinol, Nov 2015
COX1 stimulates angiogenesis and upregulates, VEGFA, Prostaglandin E2 (PGE2) and PGD2.
Pendrin and anoctamin as mediators of apical iodide efflux in thyroid cells.
Kopp et al., São Paulo, Brazil. In Curr Opin Endocrinol Diabetes Obes, Oct 2015
RECENT FINDINGS: The functional characterization of pendrin (PDS/SLC26A4), a multifunctional anion exchanger, suggested that it could be involved in mediating iodide efflux.
Novel Roles for Chloride Channels, Exchangers, and Regulators in Chronic Inflammatory Airway Diseases.
Brett et al., Saint Louis, United States. In Mediators Inflamm, 2014
In this review, we focus on the emerging novel roles for a chloride channel regulator (CLCA1), a calcium-activated chloride channel (TMEM16A), and two chloride exchangers (SLC26A4/pendrin and SLC26A9) in chronic inflammatory airway diseases.
Mast cell maturation is driven via a group III phospholipase A2-prostaglandin D2-DP1 receptor paracrine axis.
Murakami et al., Tokyo, Japan. In Nat Immunol, 2013
PLA2G3 secreted from mast cells is coupled with fibroblastic lipocalin-type PGD2 synthase (L-PGDS) to provide PGD2, which facilitates mast-cell maturation via PGD2 receptor DP1.
Sulfur as a selective 'soft' oxidant for catalytic methane conversion probed by experiment and theory.
Marks et al., Evanston, United States. In Nat Chem, 2013
We report here on elemental sulfur as a promising 'soft' oxidant for selective methane conversion to ethylene over MoS(2), RuS(2), TiS(2), PdS and Pd/ZrO(2) catalysts.
A novel insertion-induced frameshift mutation of the SLC26A4 gene in a Korean family with Pendred syndrome.
Lee et al., Taegu, South Korea. In Gene, 2012
Insertion-induced frameshift mutation of the SLC26A4 gene is associated with Pendred syndrome.
Systematic interaction analysis of human lipocalin-type prostaglandin D synthase with small lipophilic ligands.
Inui et al., Sakai, Japan. In Biochem J, 2012
Data suggest that L-PGDS binds small lipophilic ligands with both high-affinity and low-affinity interactions; molecular models are proposed from studies that include binding of hemin, biliverdin, and bilirubin.
Double knockout of pendrin and Na-Cl cotransporter (NCC) causes severe salt wasting, volume depletion, and renal failure.
Amlal et al., Cincinnati, United States. In Proc Natl Acad Sci U S A, 2012
The combined inhibition of pendrin and NCC can provide a strong diuretic regimen without causing hypokalemia.
Roles of 17-AAG-induced molecular chaperones and Rma1 E3 ubiquitin ligase in folding and degradation of Pendrin.
Hahn et al., Seoul, South Korea. In Febs Lett, 2012
Rma1, an E3 ubiquitin ligase localized in the ER membrane, is involved in Pendrin degradation
Gadkin negatively regulates cell spreading and motility via sequestration of the actin-nucleating ARP2/3 complex.
Haucke et al., Berlin, Germany. In Proc Natl Acad Sci U S A, 2012
Together with the observation that Gadkin-mediated inhibition of cell spreading requires its binding to ARP2/3, these data indicate that Gadkin is a negative regulator of ARP2/3 function present on intracellular membranes
First-in-man clinical trial of the oral pan-AKT inhibitor MK-2206 in patients with advanced solid tumors.
Tolcher et al., United Kingdom. In J Clin Oncol, 2012
A phase I study of MK-2206 was conducted to investigate its safety, maximum-tolerated dose (MTD), pharmacokinetics (PKs), pharmacodynamics (PDs), and preliminary antitumor efficacy.
Phase I pharmacokinetic and pharmacodynamic study of the oral, small-molecule mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancers.
Eckhardt et al., Buffalo, United States. In J Clin Oncol, 2008
PURPOSE: To assess the tolerability, pharmacokinetics (PKs), and pharmacodynamics (PDs) of the mitogen-activated protein kinase kinase (MEK) 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancer.
Mutations in antiquitin in individuals with pyridoxine-dependent seizures.
Clayton et al., London, United Kingdom. In Nat Med, 2006
We show here that children with pyridoxine-dependent seizures (PDS) have mutations in the ALDH7A1 gene, which encodes antiquitin; these mutations abolish the activity of antiquitin as a delta1-piperideine-6-carboxylate (P6C)-alpha-aminoadipic semialdehyde (alpha-AASA) dehydrogenase.
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