Peroxisome proliferator-activated receptor-gamma agonists inhibit experimental allergic encephalomyelitis by blocking IL-12 production, IL-12 signaling and Th1 differentiation
In Journal of Neuroinflammation, 2001
... were from Invitrogen (Carlsbad, CA); SYBR green PCR mix was from Amersham (Piscataway, NJ); 15d-PGJ2, PGD2, PGE2, PGF2α, T0070907, AH6809, BAY-u3405 and GSH kit were from Cayman Chemicals (Ann Arbor, MI); ...
Deafness gene mutations in newborns in Beijing.
Beijing, China. In Acta Otolaryngol, Feb 2016
Study sample This study tested 37 573 newborns within 3 days after birth, including nine sites in four genes: GJB2 (35 del G, 176 del 16, 235 del C, 299 del AT), SLC26A4 (IVS7-2 A > G, 2168 A > G), MTRNR1 (1555 A > G, 1494 C > T), and GJB3 (538 C > T).
The hippocampus participates in a pharmacological rat model of absence seizures.
London, Canada. In Epilepsy Res, Jan 2016
OBJECTIVE: Using the gamma-butyrolactone (GBL) model of absence seizures in Long-Evans rats, this study investigated if 2.5-6Hz paroxysmal discharges (PDs) induced by GBL were synchronized among the thalamocortical system and the hippocampus, and whether inactivation of the hippocampus affected PDs.
Genetics of Hearing Loss-Nonsyndromic.
Stanford, United States. In Otolaryngol Clin North Am, Dec 2015
Although AR nonsyndromic SNHL is most commonly caused by GJB2 and SLC26A4, there is no single gene that accounts for any significant proportion of AD SNHL.
Mutations in antiquitin in individuals with pyridoxine-dependent seizures.
London, United Kingdom. In Nat Med, 2006
We show here that children with pyridoxine-dependent seizures (PDS) have mutations in the ALDH7A1 gene, which encodes antiquitin; these mutations abolish the activity of antiquitin as a delta1-piperideine-6-carboxylate (P6C)-alpha-aminoadipic semialdehyde (alpha-AASA) dehydrogenase.