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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha

PGC-1alpha, PGC-1, PPARGC1A, PGC-1beta
The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: PGC, ACID, Insulin, CAN, PPAR
Papers on PGC-1alpha
PGC-1β suppresses saturated fatty acid-induced macrophage inflammation by inhibiting TAK1 activation.
Xia et al., Guangzhou, China. In Iubmb Life, Feb 2016
Peroxisome proliferator-activated receptor γ coactivator-1β (PGC-1β) is a member of the PGC-1 family of transcriptional coactivators and has been reported to play a key role in SFAs metabolism and in the regulation of inflammatory signaling.
Sympathetic innervation controls homeostasis of neuromuscular junctions in health and disease.
Rudolf et al., Heidelberg, Germany. In Proc Natl Acad Sci U S A, Feb 2016
Direct stimulation of sympathetic neurons led to activation of muscle postsynaptic β2-adrenoreceptor (ADRB2), cAMP production, and import of the transcriptional coactivator peroxisome proliferator-activated receptor γ-coactivator 1α (PPARGC1A) into myonuclei.
Diluted Sera From Calorie Restricted Animals Promote Mitochondrial Beta-Cell Adaptations and Protect Against Glucolipotoxicity.
Kowaltowski et al., Boston, United States. In Febs J, Feb 2016
INS1 cells incubated with CR sera presented higher levels of PGC-1-alpha and active nitric oxide synthase.
Cell-Autonomous Brown-Like Adipogenesis of Preadipocytes from Retinoblastoma Haploinsufficient Mice.
Ribot et al., Palma, Spain. In J Cell Physiol, Feb 2016
Primary white Rb(+/-) adipocytes displayed under basal conditions increased glucose uptake and an enhanced expression of brown adipocyte-related genes (Pparg, Ppargc1a, Ppargc1b, Prdm16, Cpt1b), but not of purported beige/brite transcriptional markers (Cd137, Tmem26, Tbx1, Slc27a1, Hoxc9, Shox2).
Birt-Hogg-Dubé syndrome: Clinical and molecular aspects of recently identified kidney cancer syndrome.
Yao et al., Yokohama, Japan. In Int J Urol, Dec 2015
Recent studies using murine models for FLCN, a protein encoded by the FLCN gene, and its two binding partners, folliculin-interacting protein 1 (FNIP1) and folliculin-interacting protein 2 (FNIP2), have uncovered important roles for FLCN, FNIP1 and FNIP2 in cell metabolism, which include AMP-activated protein kinase-mediated energy sensing, Ppargc1a-driven mitochondrial oxidative phosphorylation and mTORC1-dependent cell proliferation.
Effects of exercise and dietary epigallocatechin gallate and β-alanine on skeletal muscle in aged mice.
Woods et al., Urbana, United States. In Appl Physiol Nutr Metab, Nov 2015
VWR increased gastrocnemius expression of several genes, including those encoding interleukin-6 (Il6, p = 0.001), superoxide dismutase 1 (Sod1, p = 0.046), peroxisome proliferator-activated receptor gamma coactivator 1-α (Ppargc1a, p = 0.013), forkhead box protein O3 (Foxo3, p = 0.005), and brain-derived neurotrophic factor (Bdnf, p = 0.008), while reducing gastrocnemius levels of the lipid peroxidation marker 4-hydroxynonenal (p = 0.019).
Transcriptional control of circadian metabolic rhythms in the liver.
Lin et al., Ann Arbor, United States. In Diabetes Obes Metab, Sep 2015
In this review, we summarize recent findings on the integration of hepatic glucose metabolism and the body clock through a regulatory network centred on the PPARγ coactivator 1 (PGC-1) transcriptional coactivators.
The hitchhiker's guide to PGC-1α isoform structure and biological functions.
Ruas et al., Stockholm, Sweden. In Diabetologia, Sep 2015
Proteins of the peroxisome proliferator-activated receptor γ (PPARγ) coactivator 1 (PGC-1) family of transcriptional coactivators coordinate physiological adaptations in many tissues, usually in response to demands for higher nutrient and energy supply.
Intercellular: local and systemic actions of skeletal muscle PGC-1s.
Ruas et al., Stockholm, Sweden. In Trends Endocrinol Metab, Jun 2015
Peroxisome proliferator-activated receptor gamma (PPARγ) coactivator-1 (PGC-1) proteins play a prominent role in skeletal muscle transcriptional reprogramming induced by numerous stimuli.
Current Progress in Sports Genomics.
Fedotovskaya et al., Kazan', Russia. In Adv Clin Chem, 2014
Notably, 11 (9%) of these genetic markers (endurance markers: ACE I, ACTN3 577X, PPARA rs4253778 G, PPARGC1A Gly482; power/strength markers: ACE D, ACTN3 Arg577, AMPD1 Gln12, HIF1A 582Ser, MTHFR rs1801131 C, NOS3 rs2070744 T, PPARG 12Ala) have shown positive associations with athlete status in three or more studies, and six markers (CREM rs1531550 A, DMD rs939787 T, GALNT13 rs10196189 G, NFIA-AS1 rs1572312 C, RBFOX1 rs7191721 G, TSHR rs7144481 C) were identified after performing genome-wide association studies (GWAS) of African-American, Jamaican, Japanese, and Russian athletes.
PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis.
Kalluri et al., Houston, United States. In Nat Cell Biol, 2014
Invasive cancer cells use the transcription coactivator peroxisome proliferator-activated receptor gamma, coactivator 1 alpha (PPARGC1A, also known as PGC-1α) to enhance oxidative phosphorylation, mitochondrial biogenesis and the oxygen consumption rate.
Inhibition of Notch signaling promotes browning of white adipose tissue and ameliorates obesity.
Kuang et al., West Lafayette, United States. In Nat Med, 2014
At the molecular level, constitutive activation of Notch signaling inhibits, whereas Notch inhibition induces, Ppargc1a and Prdm16 transcription in white adipocytes.
Metabolic stress modulates Alzheimer's β-secretase gene transcription via SIRT1-PPARγ-PGC-1 in neurons.
Liao et al., Memphis, United States. In Cell Metab, 2013
Modest fasting in mice reduced BACE1 transcription in the brains, which was accompanied by elevated PGC-1 expression and activity.
PGC1α expression defines a subset of human melanoma tumors with increased mitochondrial capacity and resistance to oxidative stress.
Puigserver et al., Boston, United States. In Cancer Cell, 2013
Here, we report that the oncogenic melanocyte lineage-specification transcription factor MITF drives PGC1α (PPARGC1A) overexpression in a subset of human melanomas and derived cell lines.
Resveratrol supplementation does not improve metabolic function in nonobese women with normal glucose tolerance.
Klein et al., Saint Louis, United States. In Cell Metab, 2012
Consistent with the absence of in vivo metabolic effects, resveratrol did not affect its putative molecular targets, including AMPK, SIRT1, NAMPT, and PPARGC1A, in either skeletal muscle or adipose tissue.
Ablation of PGC1 beta prevents mTOR dependent endoplasmic reticulum stress response.
Vidal-Puig et al., Cambridge, United Kingdom. In Exp Neurol, 2012
Our data indicate that genetic ablation of PGC-1beta might increase the susceptibility to neuronal damage and cell death
PGC-1β regulates mouse carnitine-acylcarnitine translocase through estrogen-related receptor α.
Relat et al., Barcelona, Spain. In Biochem Biophys Res Commun, 2012
the 50-flanking region of the Cact gene contains a consensus sequence for ERRalpha. This sequence binds ERRa both in vivo and in vitro and is required for the activation of Cact expression by the PGC-1/ERR axis
PGC-1α negatively regulates extrasynaptic NMDAR activity and excitotoxicity.
Hardingham et al., Edinburgh, United Kingdom. In J Neurosci, 2012
knock-down of endogenous PGC-1a increased NMDAREX activity and vulnerability to excitotoxic insults in rat cortical neurons. In contrast, exogenous expression of PGC-1a resulted in a neuroprotective reduction of NMDAREX.
Association of the PGC-1α rs8192678 variant with microalbuminuria in subjects with type 2 diabetes mellitus.
Stephens et al., Swansea, United Kingdom. In Dis Markers, 2011
In European subjects with type 2 diabetes mellitus the GA relative to the GG genotype is associated with a 70% increase in the risk of micro/microalbuminuria.
Evaluation of gene expression profiles and pathways underlying postnatal development in mouse sclera.
Barathi et al., Singapore, Singapore. In Mol Vis, 2011
Ppargc1a might play a role in regulating postnatal scleral development by interacting with a different set of genes at different scleral growth stages.
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