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PiggyBac transposable element derived 3

PGBD3
The piggyBac family of proteins, found in diverse animals, are transposases related to the transposase of the canonical piggyBac transposon from the moth, Trichoplusia ni. This family also includes genes in several genomes, including human, that appear to have been derived from the piggyBac transposons. This gene belongs to the subfamily of piggyBac transposable element derived (PGBD) genes. The PGBD proteins appear to be novel, with no obvious relationship to other transposases, or other known protein families. This gene overlaps with the ERCC6 gene on chromosome 10, and pseudogenes of this locus have been found on chromosomes 4, 5 and 12. [provided by RefSeq, Jul 2008] (from NCBI)
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Top mentioned proteins: CSB, CAN, AP-1, SWI, REST
Papers on PGBD3
CSB-PGBD3 Mutations Cause Premature Ovarian Failure.
New
Chen et al., Jinan, China. In Plos Genet, Jul 2015
In this study, through whole exome sequencing in a non-consanguineous family having four affected members with POF and Sanger sequencing in 432 sporadic cases, we identified three novel mutations in the fusion gene CSB-PGBD3.
What role (if any) does the highly conserved CSB-PGBD3 fusion protein play in Cockayne syndrome?
Review
Gray et al., Seattle, United States. In Mech Ageing Dev, 2013
The PGBD3 piggyBac transposon inserted into CSB intron 5 early in the primate lineage.
PGBD5: a neural-specific intron-containing piggyBac transposase domesticated over 500 million years ago and conserved from cephalochordates to humans.
Weiner et al., Seattle, United States. In Mob Dna, 2012
In primates, a PGBD3 element inserted into the Cockayne syndrome group B (CSB) gene over 43 Mya serves as an alternative 3' terminal exon, enabling the CSB gene to generate both full length CSB and a conserved CSB-PGBD3 fusion protein that joins an N-terminal CSB domain to the C-terminal transposase domain.
Tethering of the conserved piggyBac transposase fusion protein CSB-PGBD3 to chromosomal AP-1 proteins regulates expression of nearby genes in humans.
Weiner et al., Seattle, United States. In Plos Genet, 2012
The CSB-PGBD3 fusion protein arose more than 43 million years ago when a 2.5-kb piggyBac 3 (PGBD3) transposon inserted into intron 5 of the Cockayne syndrome Group B (CSB) gene in the common ancestor of all higher primates.
The conserved Cockayne syndrome B-piggyBac fusion protein (CSB-PGBD3) affects DNA repair and induces both interferon-like and innate antiviral responses in CSB-null cells.
GeneRIF
Weiner et al., Seattle, United States. In Dna Repair (amst), 2012
CSB-PGBD3 fusion protein is important in both health and disease, and could play a role in Cockayne syndrome.
An abundant evolutionarily conserved CSB-PiggyBac fusion protein expressed in Cockayne syndrome.
GeneRIF
Weiner et al., Seattle, United States. In Plos Genet, 2008
a domesticated PiggyBac-like transposon PGBD3, residing within intron 5 of the CSB gene, functions as an alternative 3' terminal exon
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