Regulation of Lrp6 phosphorylation.
Heidelberg, Germany. In Cell Mol Life Sci, 2010
Here, we summarize how proline-directed kinases (Gsk3, PKA, Pftk1, Grk5/6) and non-proline-directed kinases (CK1 family) act upon Lrp6, how the phosphorylation is regulated by ligand binding and mitosis, and how Lrp6 phosphorylation leads to beta-catenin stabilization.
Thyrotropin-releasing hormone (TRH) in the cerebellum.
Maebashi, Japan. In Cerebellum, 2007
Further analysis of TRH-deficient mice revealed that the expression of PFTAIRE protein kinase1 (PFTK1), a cdc2-related kinase, in the cerebellum was induced by TRH through the NO-cGMP pathway.