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Sulfatase modifying factor 2

pFGE, SUMF2, sulfatase modifying factor 2
The catalytic sites of sulfatases are only active if they contain a unique amino acid, C-alpha-formylglycine (FGly). The FGly residue is posttranslationally generated from a cysteine by enzymes with FGly-generating activity. The gene described in this record is a member of the sulfatase-modifying factor family and encodes a protein with a DUF323 domain that localizes to the lumen of the endoplasmic reticulum. This protein has low levels of FGly-generating activity but can heterodimerize with another family member - a protein with high levels of FGly-generating activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] (from NCBI)
Papers on pFGE
SUMF2 interacts with interleukin-13 and inhibits interleukin-13 secretion in bronchial smooth muscle cells.
GeneRIF
Liu et al., Harbin, China. In J Cell Biochem, 2010
SUMF2 interacted with IL-13 and inhibited IL-13 secretion in bronchial smooth muscle cells and lymphocytes, which was independent of IL-13 glycosylation
Paralog of the formylglycine-generating enzyme--retention in the endoplasmic reticulum by canonical and noncanonical signals.
GeneRIF
Dierks et al., Göttingen, Germany. In Febs J, 2008
pFGE is retained in the ER through its C-terminal tetrapeptide PGEL, a noncanonical variant of the classic KDEL ER-retention signal.
Sulphatase activities are regulated by the interaction of sulphatase-modifying factor 1 with SUMF2.
GeneRIF
Cosma et al., Napoli, Italy. In Embo Rep, 2005
SUMF2 interacts with sulphatase-modifying factor 1 to regulate sulphatase activities.
Crystal structure of human pFGE, the paralog of the Calpha-formylglycine-generating enzyme.
GeneRIF
Ficner et al., Göttingen, Germany. In J Biol Chem, 2005
structural analysis of human pFGE by X-ray crystallography [pFGE]
Expression, localization, structural, and functional characterization of pFGE, the paralog of the Calpha-formylglycine-generating enzyme.
GeneRIF
von Figura et al., Göttingen, Germany. In J Biol Chem, 2005
pFGE (SUMF2) is the paralog of the Calpha-formylglycine-generating enzyme
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