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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Peroxisomal biogenesis factor 2

PEX2, PAF-1, peroxisome assembly factor-1, TRIP8b, Pex2p
This gene encodes an integral peroxisomal membrane protein required for peroxisome biogenesis. The protein is thought to be involved in peroxisomal matrix protein import. Mutations in this gene result in one form of Zellweger syndrome and infantile Refsum disease. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, PAF, Cho, PEX12, PEX10
Papers on PEX2
Hypercrosslinked Additives for Ageless Gas-Separation Membranes.
Wood et al., Australia. In Angew Chem Int Ed Engl, Feb 2016
Previously we reported that a porous aromatic framework (PAF-1) could form a remarkable nanocomposite with gas-separation polymers to stop aging.
Reduction of thalamic and cortical Ih by deletion of TRIP8b produces a mouse model of human absence epilepsy.
Chetkovich et al., Chicago, United States. In Neurobiol Dis, Jan 2016
Here, we identify tetratricopeptide-containing Rab8b-interacting protein (TRIP8b) knockout mice as a new model of absence epilepsy, featuring spontaneous spike-wave discharges on electroencephalography (EEG) that are the electrographic hallmark of absence seizures.
Gene-based meta-analysis of genome-wide association studies implicates new loci involved in obesity.
Ingelsson et al., Uppsala, Sweden. In Hum Mol Genet, Jan 2016
In Stage 1, two known (FTO and TMEM18) and six novel (PEX2, MTFR2, SSFA2, IARS2, CEP295 and TXNDC12) loci were associated with BMI (P < 2.8 × 10(-6) for 17 941 gene tests).
Identification of Small-Molecule Inhibitors of Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels.
Chetkovich et al., Chicago, United States. In J Biomol Screen, Oct 2015
Previous studies indicated that the function of HCN is tightly regulated by its auxiliary subunit, tetratricopeptide repeat-containing Rab8b interacting protein (TRIP8b), which is not expressed in the heart.
Structural mechanism for the regulation of HCN ion channels by the accessory protein TRIP8b.
Stoll et al., Seattle, United States. In Structure, May 2015
TRIP8b is an accessory protein that regulates the cell surface expression and dendritic localization of HCN channels and reduces the cyclic nucleotide dependence of these channels.
Gas-separation membranes loaded with porous aromatic frameworks that improve with age.
Hill et al., Australia. In Angew Chem Int Ed Engl, Mar 2015
PAF-1 is used in the archetypal polymer of intrinsic microporosity (PIM), PIM-1, to achieve three significant outcomes.
Nitrogen-doped porous aromatic frameworks for enhanced CO2 adsorption.
Jiang et al., Riverside, United States. In J Colloid Interface Sci, Feb 2015
Among various NPAFs considered, one with imidazole groups shows the highest adsorption capacity for CO2 (11.5 wt% at 1 bar and 298 K), in comparison with 5 wt% for the parent PAF (PAF-1) at the same condition.
Imbalance of HCN1 and HCN2 expression in hippocampal CA1 area impairs spatial learning and memory in rats with chronic morphine exposure.
Guo et al., Wuhan, China. In Prog Neuropsychopharmacol Biol Psychiatry, Feb 2015
Additional experiments showed that the imbalance of cell membrane HCN1 and HCN2 expression under chronic morphine exposure was related to an increase in expression of TPR containing Rab8b interacting protein (TRIP8b) (1a-4) and TRIP8b (1b-2), and phosphorylation of protein kinase A (PKA) and adaptor protein 2 μ2 (AP2 μ2).
Associations between menarche-related genetic variants and pubertal growth in male and female adolescents.
He et al., Indianapolis, United States. In J Adolesc Health, 2015
RESULTS: Longitudinal analyses revealed that 4 (near or in genes VGLL3, PEX2, CA10, and SKOR2) of the 14 menarche-only-related SNPs were associated with changes in weight and BMI in EA and AA (p ≤ .0032),
Cortical HCN channels: function, trafficking and plasticity.
Shah, London, United Kingdom. In J Physiol, 2014
HCN channels are actively trafficked to dendrites by binding to the chaperone protein TRIP8b.
Neurophysiology of HCN channels: from cellular functions to multiple regulations.
Hu et al., Chongqing, China. In Prog Neurobiol, 2014
In the next section, we discuss how the intracellular signals, especially recent findings concerning protein kinases and interacting proteins such as cGKII, Ca(2+)/CaMKII and TRIP8b, regulate function and expression of HCN channels, and subsequently provide an overview of the effects of neurotransmitters on HCN channels and their corresponding intracellular mechanisms.
Peroxisomes and photomorphogenesis.
Hu et al., East Lansing, United States. In Subcell Biochem, 2012
Lastly, a gain-of-function mutant of the peroxisomal membrane-tethered RING-type E3 ubiquitin ligase PEX2 partially suppresses the phenotype of the photomorphogenic mutant det1.
Regulation of axonal HCN1 trafficking in perforant path involves expression of specific TRIP8b isoforms.
Bender et al., Hamburg, Germany. In Plos One, 2011
TRIP8b isoforms are important regulators of HCN1 trafficking in entorhinal neurons.
Corticospinal-specific HCN expression in mouse motor cortex: I(h)-dependent synaptic integration as a candidate microcircuit mechanism involved in motor control.
Shepherd et al., Chicago, United States. In J Neurophysiol, 2011
Hyperpolarization current expression was high in corticospinal neurons and low in corticostriatal and corticocortical neurons, a pattern mirrored by mRNA levels for HCN1 and Trip8b subunits.
Elevation of hemopexin-like fragment of matrix metalloproteinase-2 tissue levels inhibits ischemic wound healing and angiogenesis.
Velazquez et al., Miami, United States. In J Vasc Surg, 2011
Study links elevated MMP-2/PEX2 to ischemia and poor wound healing.
Association of adaptor protein TRIP8b with clathrin.
Petrenko et al., Moscow, Russia. In J Neurochem, 2011
Our data suggest complex regulatory functions of TRIP8b in neuronal endocytosis through independent interaction with membrane proteins and components of the clathrin coat
Deletion of the hyperpolarization-activated cyclic nucleotide-gated channel auxiliary subunit TRIP8b impairs hippocampal Ih localization and function and promotes antidepressant behavior in mice.
Chetkovich et al., Chicago, United States. In J Neurosci, 2011
Mice lacking TRIP8b demonstrate motor learning deficits and enhanced resistance to multiple tasks of behavioral despair with high predictive validity for antidepressant efficacy.
The fast and slow ups and downs of HCN channel regulation.
Chetkovich et al., Chicago, United States. In Channels (austin), 2010
Here we provide a focused review examining mechanisms of h channel regulation, with an emphasis on recent findings regarding interacting proteins such as TRIP8b.
Peroxisome biogenesis disorders: the role of peroxisomes and metabolic dysfunction in developing brain.
Wikander et al., New York City, United States. In J Inherit Metab Dis, 2004
The PEX2-/- mouse model for Zellweger syndrome has enabled us to evaluate the role of peroxisomes in the development and functioning of the nervous system.
A human gene responsible for Zellweger syndrome that affects peroxisome assembly.
Fujiki et al., Gifu, Japan. In Science, 1992
The cause of the syndrome in this patient was a point mutation that resulted in the premature termination of peroxisome assembly factor-1.
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