Hsa-miR-195 targets PCMT1 in hepatocellular carcinoma that increases tumor life span.
Cairo, Egypt. In Tumour Biol, 2014
FGF7, GHR, PCMT1, CITED2, PEX5, PEX13, NOVA1, AXIN2, and TSPYL2 were detected with high significant (P < 0.005).
Peroxisome biogenesis in mammalian cells.
Fukuoka, Japan. In Front Physiol, 2013
In regard to peroxisome-cytoplasmic shuttling of Pex5p, Pex5p initially targets to an 800-kDa docking complex consisting of Pex14p and Pex13p and then translocates to a 500-kDa RING translocation complex.
Cre-mediated stress affects sirtuin expression levels, peroxisome biogenesis and metabolism, antioxidant and proinflammatory signaling pathways.
Gießen, Germany. In Plos One, 2011
Our results indicate that Cre-expression itself in Sertoli cells already has led to oxidative stress and lipid peroxidation (4-HNE lysine adducts), inducing PPARα/γ, peroxisome proliferation and alterations of peroxisome biogenesis (PEX5, PEX13 and PEX14) as well as metabolic proteins (ABCD1, ABCD3, MFP1, thiolase B, catalase).
Targeting of Pex8p to the peroxisomal importomer.
Bochum, Germany. In Eur J Cell Biol, 2010
Data demonstrate that Pex8p is capable to interact with the PTS2-receptor Pex7p and the docking complex component Pex13p with its C-terminal SH3-domain providing the binding site.
Dynamic architecture of the peroxisomal import receptor Pex5p.
Hamburg, Germany. In Biochim Biophys Acta, 2006
Despite evidence for alpha-helical binding motifs for some of these components (Pex13p, Pex14p) its overall appearance is that of a molten globule and folding/unfolding transitions may play a critical role in its function.
Pex13p: docking or cargo handling protein?
Amsterdam, Netherlands. In Biochim Biophys Acta, 2006
The Src homology 3 (SH3) domain-containing peroxisomal membrane protein Pex13p is an essential component of the import machinery for matrix proteins and forms a binding site for the peroxisomal targeting type I (PTS1) receptor Pex5p.
Peroxisome Biogenesis Disorders, Zellweger Syndrome Spectrum
Seattle, United States. In Unknown Journal, 2004
CLINICAL CHARACTERISTICS: Peroxisome biogenesis disorders, Zellweger syndrome spectrum (PBD, ZSS) is a continuum of three phenotypes — Zellweger syndrome (ZS), the most severe; neonatal adrenoleukodystrophy (NALD); and infantile Refsum disease (IRD), the least severe — that were originally described before the biochemical and molecular bases of these disorders had been fully determined.