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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 24 Oct 2014.

PEX11 Pex11p

PEX11, Pex11p, PEX11alpha, PMP27
localized to the peroxisomal membrane; contains a dilysine motif that binds coatamer; may play a role in peroxisome membrane biogenesis [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: ACID, CAN, Dynamin I, HAD, Fis1
Papers on PEX11
Lumenal peroxisomal protein aggregates are removed by concerted fission and autophagy events.
New
van der Klei et al., Groningen, Netherlands. In Autophagy, Jul 2013
In line with this observation we showed that the degradation of the protein aggregates was strongly reduced in dnm1 and pex11 cells in which peroxisome fission is reduced.
Proteins and lipids of glycosomal membranes from Leishmania tarentolae and Trypanosoma brucei.
Clayton et al., Gießen, Germany. In F1000res, 2012
The proteins included approximately 40 glycosomal matrix proteins, and homologues of peroxisomal membrane proteins - PEX11, GIM5A and GIM5B; PXMP4, PEX2 and PEX16 - as well as the transporters GAT1 and GAT3.
PEX11 proteins attract Mff and human Fis1 to coordinate peroxisomal fission.
Brocard et al., Vienna, Austria. In J Cell Sci, 2012
Proteins of the PEX11 family were shown to act as membrane elongation factors during peroxisome proliferation.
[Bioinformatic research of the family of PEX11, peroxisome proliferous factor in fungus].
Sun et al., Hangzhou, China. In Yi Chuan, 2012
Sixty-six PEX11p candidates of PEX11 gene family from 26 representative fungal species were obtained and analyzed by bioinformatic strategies.
First PEX11β patient extends spectrum of peroxisomal biogenesis disorder phenotypes.
Gärtner et al., Göttingen, Germany. In J Med Genet, 2012
Among the human PEX genes associated with peroxisome biogenesis disorders, only the PEX11 family genes had not previously been associated with human disease.
A subtle interplay between three Pex11 proteins shapes de novo formation and fission of peroxisomes.
GeneRIF
Hartig et al., Vienna, Austria. In Traffic, 2012
ScPex11p promotes the proliferation of peroxisomes already present in the cell, ScPex25p initiates remodeling at the peroxisomal membrane and ScPex27p acts to counter this activity.
How peroxisomes affect aflatoxin biosynthesis in Aspergillus flavus.
Fanelli et al., Roma, Italy. In Plos One, 2011
In our preliminary results, the use of bezafibrate, inducer of both peroxisomal β-oxidation and peroxisome proliferation in mammals, significantly enhanced the expression of pex11 and foxA and stimulated aflatoxin synthesis in A. flavus.
Expression of a lipid-inducible, self-regulating form of Yarrowia lipolytica lipase LIP2 in Saccharomyces cerevisiae.
Dyer et al., New Orleans, United States. In Appl Microbiol Biotechnol, 2011
Specifically, LIP2 expression was driven by the S. cerevisiae PEX11 promoter, which maintains basal transgene expression levels in the presence of sugars in the culture medium but is rapidly upregulated by fatty acids.
Peroxisome fission is associated with reorganization of specific membrane proteins.
Nagotu et al., Groningen, Netherlands. In Traffic, 2011
We show that different peroxisome membrane proteins that play a role in organelle biogenesis and proliferation (Pex8, Pex10, Pex14, Pex25 and Pex11) are subject to spatiotemporal behavior during organelle development.
The conserved fission complex on peroxisomes and mitochondria.
Hu et al., East Lansing, United States. In Plant Signal Behav, 2011
These include five PEROXIN11 proteins (PEX11a to -e) that induce peroxisome elongation, and the fission machinery, which is composed of three dynamin-related proteins (DRP3A, -3B, and -5B) and DRP's membrane receptor, FISSION1 (FIS1A and -1B).
Peroxisome reintroduction in Hansenula polymorpha requires Pex25 and Rho1.
van der Klei et al., Groningen, Netherlands. In J Cell Biol, 2011
Of the three members of the Hansenula polymorpha Pex11 protein family-Pex11, Pex25, and Pex11C-only Pex25 was required for reintroduction of peroxisomes into a peroxisome-deficient mutant strain.
PEX11 family members are membrane elongation factors that coordinate peroxisome proliferation and maintenance.
GeneRIF
Brocard et al., Vienna, Austria. In J Cell Sci, 2010
coordinates peroxisome membrane proliferation and maintenance
Peroxisome division and proliferation in plants.
Review
Hu et al., East Lansing, United States. In Biochem Soc Trans, 2010
Research in Arabidopsis thaliana has identified several evolutionarily conserved major components of the peroxisome division machinery, including five isoforms of PEROXIN11 proteins (PEX11), two dynamin-related proteins (DRP3A and DRP3B) and two FISSION1 proteins (FIS1A/BIGYIN and FIS1B).
Phosphorylation-dependent activation of peroxisome proliferator protein PEX11 controls peroxisome abundance.
GeneRIF
Rachubinski et al., Edmonton, Canada. In J Biol Chem, 2010
report the reversible phosphorylation of Pex11p in response to nutritional cues and delineate a mechanism for phosphorylation-dependent activation of Pex11p and peroxisome proliferation
Salt stress causes peroxisome proliferation, but inducing peroxisome proliferation does not improve NaCl tolerance in Arabidopsis thaliana.
Baker et al., Leeds, United Kingdom. In Plos One, 2009
The PEX11 family of peroxisome membrane proteins have been shown to be involved in regulation of peroxisome size and number in plant, animals, and yeast cells.
Dynamics of peroxisome abundance: a tale of division and proliferation.
Review
Hu et al., East Lansing, United States. In Curr Opin Plant Biol, 2009
These include the PEROXIN11 (PEX11) family, the dynamin-related proteins (DRPs), and the FISSION1 (FIS1) proteins, some of which are shared by the division machineries of peroxisomes and other organelles.
Peroxisome biogenesis: where Arf and coatomer might be involved.
Review
Just et al., Heidelberg, Germany. In Biochim Biophys Acta, 2006
Studies on the expression of mammalian Pex11 proteins, mainly Pex11alpha and Pex11beta, intimately related to the process of peroxisome proliferation, revealed a sequence of individual steps including organelle elongation/tubulation, formation of membrane and matrix protein patches segregating distinct proteins from each other, development of membrane constrictions and final membrane fission.
Peroxisome proliferator-activated receptor subtypes differentially cooperate with other transcription factors in selective transactivation of the perilipin/PEX11 alpha gene pair.
GeneRIF
Osumi et al., Himeji, Japan. In J Biochem, 2006
Cooperation with other transcription factors may be differentially involved in selective transactivation of the PEX11alpha gene by different peroxisome proliferator-activated receptor subtypes.
PEX11alpha is required for peroxisome proliferation in response to 4-phenylbutyrate but is dispensable for peroxisome proliferator-activated receptor alpha-mediated peroxisome proliferation.
GeneRIF
Gould et al., Baltimore, United States. In Mol Cell Biol, 2002
Mice lacking PEX11-alpha have normal peroxisome abundance.
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