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Pescadillo homolog 1, containing BRCT domain

This gene encodes a nuclear protein that contains a breast cancer associated gene 1 (BRCA1) C-terminal interaction domain. The encoded protein interacts with BOP1 and WDR12 to form the PeBoW complex, which plays a critical role in cell proliferation via pre-rRNA processing and 60S ribosomal subunit maturation. Expression of this gene may play an important role in breast cancer proliferation and tumorigenicity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the long arm of chromosome 4 and the short arm of chromosome 9. [provided by RefSeq, Aug 2011] (from NCBI)
Top mentioned proteins: CAN, ACID, STEP, V1a, CHIP
Papers on Pes1
Permutationally invariant fitting of intermolecular potential energy surfaces: A case study of the Ne-C2H2 system.
Guo et al., Chongqing, China. In J Chem Phys, Jan 2016
PES1 is a full nine-dimensional PIP-NN PES directly fitted to ∼42 000 ab initio points calculated at the level of CCSD(T)-F12a/cc-pCVTZ-F12, while the other two consist of the six-dimensional PES for C2H2 [H.
Repression of PES1 expression inhibits growth of gastric cancer.
Huang et al., Fuzhou, China. In Tumour Biol, Oct 2015
We recently reported that PES1 promoted development of breast cancer and ovarian cancer as an oncogene.
Nucleolar protein PES1 is a marker of neuroblastoma outcome and is associated with neuroblastoma differentiation.
Kadomatsu et al., Nagoya, Japan. In Cancer Sci, Mar 2015
PES1 is a multifunctional protein with roles in both neural development and ribosome biogenesis.
[Effect of andrographolide on Candida albicans biofilm dispersion].
Wang et al., In Zhongguo Zhong Yao Za Zhi, 2014
According to the real-time fluorescence quantification PCR (qRT-PCR) test, AG could up-regulate HSP90 expression and down-regulate UME6 and PES1 expressions.
PES1 differentially regulates the expression of ERα and ERβ in ovarian cancer.
Huang et al., Fuzhou, China. In Iubmb Life, 2013
We have recently reported that PES1 regulates the balance of ERα and ERβ at the post-transcriptional level in breast cancer.
Molecular pathology of brain edema after severe burns in forensic autopsy cases with special regard to the importance of reference gene selection.
Maeda et al., Guangzhou, China. In Int J Legal Med, 2013
Prolonged deaths due to severe burns showed an increase in brain water content, but relative mRNA quantification, using different normalization methods, showed inconsistent results: in prolonged deaths due to severe burns, higher expression levels were detected for all markers when three previously validated reference genes, PES1, POLR2A, and IPO8, were used for normalization, higher for AQP1 and MMP9 when GAPDH alone was used for normalization and higher for MMP9, but lower for MMP2 when B2M alone was used for normalization.
PES1 regulates sensitivity of colorectal cancer cells to anticancer drugs.
Shou et al., Beijing, China. In Biochem Biophys Res Commun, 2013
PES1 (also known as Pescadillo), a nucleolar protein, was involved in biogenesis of ribosomal RNA.
Physiologic expression of the Candida albicans pescadillo homolog is required for virulence in a murine model of hematogenously disseminated candidiasis.
Lopez Ribot et al., San Antonio, United States. In Eukaryot Cell, 2012
We previously identified the C. albicans pescadillo homolog (PES1) as essential during yeast growth and growth of lateral yeast on hyphae but not during hyphal growth.
Stability of endogenous reference genes in postmortem human brains for normalization of quantitative real-time PCR data: comprehensive evaluation using geNorm, NormFinder, and BestKeeper.
Maeda et al., Ōsaka, Japan. In Int J Legal Med, 2012
Combining these three algorithms suggested the genes IPO8, POLR2A, and PES1 as stable endogenous references in RT-qPCR analysis of human brain samples, with YWHAZ, PPIA, HPRT1, and TBP being the least stable ones.
PES1 promotes breast cancer by differentially regulating ERα and ERβ.
Ye et al., Beijing, China. In J Clin Invest, 2012
expression of PES1 correlated positively with ERalpha expression and negatively with ERbeta expression and predicted good clinical outcome in breast cancer
Targeting PES1 for restoring the ERα/ERβ ratio in breast cancer.
Gustafsson et al., In J Clin Invest, 2012
In this issue of JCI, Cheng et al. show that, by differentially modulating the stability of ERα and ERβ, PES1 increases the ERα/ERβ ratio and triggers breast tumor growth.
Transcriptional regulation of PES1 expression by c-Jun in colon cancer.
Shou et al., Beijing, China. In Plos One, 2011
Deregulated expression of human pescadillo (PES1) was described in some tumors, but its precise roles in tumorigenesis remains unclear.
Identification of suitable reference genes for real-time PCR analysis of statin-treated human umbilical vein endothelial cells.
Koziak et al., Warsaw, Poland. In Plos One, 2011
In this article we have assessed the expression stability of eight putative reference genes: ACTB, B2M, GADD45A, GAPDH, HPRT1, PES1, PSMC4, YWHAZ, in human umbilical vein endothelial cells (HUVEC) treated with different statins and with TNF-α.
What makes Aspergillus fumigatus a successful pathogen? Genes and molecules involved in invasive aspergillosis.
Rementeria et al., Leioa, Spain. In Rev Iberoam Micol, 2010
These sections include β-glucan, α-glucan, chitin, galactomannan, galactomannoproteins (afmp1/asp f 17 and afmp2), hydrophobins (rodA/hyp1 and rodB), DHN-melanin, their respective synthases (fks1, rho1-4, ags1-3, chsA-G, och1-4, mnn9, van1, anp1, glfA, pksP/alb1, arp1, arp2, abr1, abr2, and ayg1), and modifying enzymes (gel1-7, bgt1, eng1, ecm33, afpigA, afpmt1-2, afpmt4, kre2/afmnt1, afmnt2-3, afcwh41 and pmi); several enzymes related to oxidative stress protection such as catalases (catA, cat1/catB, cat2/katG, catC, and catE), superoxide dismutases (sod1, sod2, sod3/asp f 6, and sod4), fatty acid oxygenases (ppoA-C), glutathione tranferases (gstA-E), and others (afyap1, skn7, and pes1); and efflux transporters (mdr1-4, atrF, abcA-E, and msfA-E).
Down-regulation of pescadillo inhibits proliferation and tumorigenicity of breast cancer cells.
Li et al., Guangzhou, China. In Cancer Sci, 2009
pescadillo might play a role in promoting the proliferation and carcinogenesis of human breast cancer, and thereby might be a potential target for human breast cancer treatment.
B23 interacts with PES1 and is involved in nucleolar localization of PES1.
Wu et al., Shanghai, China. In Acta Biochim Biophys Sin (shanghai), 2009
The physical interaction between B23 and PES1 implies that they may participate in ribosome biogenesis in a protein complex.
Interdependence of Pes1, Bop1, and WDR12 controls nucleolar localization and assembly of the PeBoW complex required for maturation of the 60S ribosomal subunit.
Eick et al., München, Germany. In Mol Cell Biol, 2007
Results describe the role of PeBoW-specific proteins Pes1, Bop1, and WDR12 in complex assembly and stability, nucleolar transport, and pre-ribosome association.
Light chain 1 of microtubule-associated protein 1B can negatively regulate the action of Pes1.
Duncan et al., Milwaukee, United States. In J Biol Chem, 2007
Mtap1b-Light chain 1 has the potential to repress cell proliferation by modulating the nucleolar levels of Pes1
Production of a potentially novel anti-microbial substance by Bacillus polymyxa.
Seldin et al., Rio de Janeiro, Brazil. In World J Microbiol Biotechnol, 1993
The B. polymyxa strain harboured a plasmid that did not correlate with antibiotic production; after curing experiments, a derivative strain, SCE2(46), was isolated that lacked the plasmid pES1, but showed the same inhibitory spectrum as the wild-type strain.
Two biochemically and genetically different forms of L dsRNA of Saccharomyces cerevisiae exist: One form, L2, is correlated.
Mitchell et al., London, United Kingdom. In Curr Genet, 1983
L2 dsRNA was shown to be dependent upon MAK3, MAK10 and PES1 but not MAK1 nuclear genes for its maintenance.
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