gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Peroxiredoxin 5

peroxiredoxin 5, Thioredoxin reductase, ACR1, PRDX5, Peroxiredoxin V
This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in different tissues under normal conditions and during inflammatory processes. This protein interacts with peroxisome receptor 1. The crystal structure of this protein in its reduced form has been resolved to 1.5 angstrom resolution. This gene uses alternate in-frame translation initiation sites to generate mitochondrial or peroxisomal/cytoplasmic forms. Three transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Thioredoxin, CAN, ACID, Ros, fibrillin-1
Papers on peroxiredoxin 5
Proteomonas sulcata ACR1: A Fast Anion Channelrhodopsin.
New
Spudich et al., Houston, United States. In Photochem Photobiol, Jan 2016
UNASSIGNED: Natural channelrhodopsins with strictly anion selectivity and high unitary conductance have been recently discovered in the cryptophyte alga Guillardia theta.
Redoxins in peripheral neurons after sciatic nerve injury.
New
Tegeder et al., Frankfurt am Main, Germany. In Free Radic Biol Med, Dec 2015
The expression and localization of Glrx, Txn and Txnrd proteins was not affected by sciatic nerve injury but peroxiredoxins were upregulated in the DRGs, Prdx1 and Prdx6 mainly in non-neuronal cells and Prdx4 and Prdx5 in DRG neurons, the latter associated with an increase of respective mRNAs and protein accumulation in peripheral and/or central fibers.
Effects of short-term exposure of mature oocytes to sodium nitroprusside on in vitro embryo production and gene expression in bovine.
New
Sánchez et al., Temuco, Chile. In Theriogenology, Nov 2015
This study assessed the effects of exposing bovine oocytes to a nitric oxide (NO) donor, sodium nitroprusside (SNP), on subsequent in vitro embryo production, embryo quality and the expression of genes involved in NO production (iNOS, eNOS, and nNOS), stress tolerance (HSP70 and HSP90), oxidative stress (HIF1A and PRDX5), and apoptosis (BCL2A1).
Variable protein profiles in extracellular products of the protistan parasite Perkinsus olseni among regions of the Spanish coast.
New
Cao et al., Vilanova i la Geltrú, Spain. In J Invertebr Pathol, Nov 2015
Pepsin A precursor, involved in proteolysis; heat shock protein (HSP) 60; and phosphoserine aminotransferase, involved in biosynthesis, were representative of P. olseni ECPs from Ría de Arousa, while peroxiredoxin V, involved in oxidation-reduction, was representative of P. olseni ECPs from Ría de Pontevedra.
Expression and distribution of peroxiredoxins in the retina and optic nerve.
New
Casson et al., Adelaide, Australia. In Brain Struct Funct, Nov 2015
In the retina, Prdx1 and Prdx2 were principally localized to neurons in the inner nuclear layer and cone photoreceptors, Prdx3 and Prdx5 displayed characteristic mitochondrial immunolabeling, while Prdx6 was associated with astrocytes and Müller cells.
Increased serum peroxiredoxin 5 levels in myasthenia gravis.
New
Kuwabara et al., Chiba, Japan. In J Neuroimmunol, Nov 2015
Extracellular peroxiredoxin 5 (PRX5) is known to be an inflammatory mediator.
The evolving versatility of selenium in biology.
New
Brigelius-Flohé, Potsdam, Germany. In Antioxid Redox Signal, Nov 2015
Thioredoxin reductase 1 (TrxR1) can change from an anti- to a pro-oxidant and appears to be involved in the regulation of the Nrf2/Keap1 system.
Differences in Redox Regulatory Systems in Human Lung and Liver Tumors Suggest Different Avenues for Therapy.
Hatfield et al., Bethesda, United States. In Cancers (basel), 2014
Thioredoxin reductase 1 levels were elevated in both malignancies, but thioredoxin was highly upregulated in lung tumor and only slightly upregulated in liver tumor, while peroxiredoxin 1 was highly elevated in lung tumor, but downregulated in liver tumor.
Plasmodium falciparum Thioredoxin Reductase (PfTrxR) and Its Role as a Target for New Antimalarial Discovery.
Review
Calderón et al., Auburn, United States. In Molecules, 2014
Thioredoxin reductase (TrxR), an enzyme needed to maintain redox equilibrium in Plasmodium species, is a promising target for new antimalarials.
Thioredoxin reductase and its inhibitors.
Review
Bellelli et al., Roma, Italy. In Curr Protein Pept Sci, 2013
Thioredoxin plays a crucial role in a wide number of physiological processes, which span from reduction of nucleotides to deoxyriboucleotides to the detoxification from xenobiotics, oxidants and radicals.
Drosophila melanogaster - an embryonic model for studying behavioral and biochemical effects of manganese exposure.
Posser et al., São Gabriel, Brazil. In Excli J, 2013
At 1 mM, Mn increased Catalase (p < 0.005), Superoxide Dismutase (p < 0.005) and Hsp83 (p < 0.0001) mRNA expression, without altering Catalase or Superoxide Dismutase activity; the activity of Thioredoxin reductase and Glutatione-S-transferase enzymes was increased.
Dietary inorganic nitrate alleviates doxorubicin cardiotoxicity: mechanisms and implications.
Review
Kukreja et al., Richmond, United States. In Nitric Oxide, 2012
Furthermore, proteomic studies revealed enhanced cardiac expression of mitochondrial antioxidant enzyme - peroxiredoxin 5 in the nitrate-treated animals.
GATA-binding protein 1 is a novel transcription regulator of peroxiredoxin 5 in human breast cancer cells.
GeneRIF
Park et al., Seoul, South Korea. In Int J Oncol, 2012
The promoter region critical for Prx5 gene regulation to which the novel negative transcription regulator, GATA1 binds in human breast cancer cell lines.
Peroxiredoxin 5: structure, mechanism, and function of the mammalian atypical 2-Cys peroxiredoxin.
Review
Declercq et al., Louvain-la-Neuve, Belgium. In Antioxid Redox Signal, 2011
Peroxiredoxin 5 (PRDX5) was the last member to be identified among the six mammalian peroxiredoxins.
Transcription factor GABP/NRF-2 controlling biogenesis of mitochondria regulates basal expression of peroxiredoxin V but the mitochondrial function of peroxiredoxin V is dispensable in the dog.
GeneRIF
Kropotov et al., Saint Petersburg, Russia. In Biochimie, 2011
basal expression of the human PRDX5 gene is regulated by GABP
Genome-wide association study in alopecia areata implicates both innate and adaptive immunity.
Impact
Christiano et al., New York City, United States. In Nature, 2010
We also find association evidence for regions containing genes expressed in the hair follicle itself (PRDX5 and STX17).
Discovery of fragment molecules that bind the human peroxiredoxin 5 active site.
GeneRIF
Krimm et al., Villeurbanne, France. In Plos One, 2009
analysis of fragment molecules that bind the human peroxiredoxin 5 active site
Characterization of the DNA-binding motif of the arsenic-responsive transcription factor Yap8p.
GeneRIF
Tamás et al., Göteborg, Sweden. In Biochem J, 2008
Yap8p requires distinct DNA-binding motifs to induce gene expression and propose that this fact contributed towards a separation of function between AP-1 proteins during evolution
Ets regulates peroxiredoxin1 and 5 expressions through their interaction with the high-mobility group protein B1.
GeneRIF
Kohno et al., Kitakyūshū, Japan. In Cancer Sci, 2008
Ets regulates PRDX5 expression through their interaction with HGMB1 protein.
[Thioredoxin reductase--a new target for molecular medical investigations].
Review
Zagrodzki, In Postepy Hig Med Dosw, 2001
Thioredoxin reductase (TrxR) is the first selenoenzyme containing selenocysteine in the active center and FAD as a second prosthetic group.
share on facebooktweetadd +1mail to friends