gopubmed logo
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.


This gene encodes a cytoskeletal protein found in neurons of the peripheral nervous system. The encoded protein is a type III intermediate filament protein with homology to other cytoskeletal proteins such as desmin, and is a different protein that the peripherin found in photoreceptors. Mutations in this gene have been associated with susceptibility to amyotrophic lateral sclerosis. [provided by RefSeq, Jul 2008] (from NCBI)
Papers on Peripherin
Peripherin is a subunit of peripheral nerve neurofilaments: implications for differential vulnerability of CNS and peripheral nervous system axons.
Nixon et al., New York City, United States. In J Neurosci, 2012
rather than forming an independent structure, peripherin is a subunit of neurofilaments in the adult peripheral nervous system
Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.
Bahn et al., Cambridge, United Kingdom. In J Proteome Res, 2012
A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration.
Isoform-specific expression and ratio changes accompany oxidant-induced peripherin aggregation in a neuroblastoma cell line.
Robertson et al., Toronto, Canada. In Brain Res, 2011
Peripherin isoform expression and inclusion formation serve a physiologically relevant role in the pathology of amyotrophic lateral sclerosis.
Peripherin partially localizes in Bunina bodies in amyotrophic lateral sclerosis.
Okamoto et al., Maebashi, Japan. In J Neurol Sci, 2011
although the mechanisms underlying peripherin co-localization in Bunina bodies are unknown, peripherin could be involved in forming these inclusions
Expression of peripherin in human cochlea.
Rask-Andersen et al., Uppsala, Sweden. In Cell Tissue Res, 2010
study analyzed expression of peripherin(PP) in the cochlea; in organ of Corti, PP seems to be specifically expressed in outer hair cell afferents; small or type II spiral ganglion cell bodies also intensely express PP
share on facebooktweetadd +1mail to friends