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Period homolog 2

period 2, Per2, mPer2
This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. Circadian expression in the suprachiasmatic nucleus continues in constant darkness, and a shift in the light/dark cycle evokes a proportional shift of gene expression in the suprachiasmatic nucleus. The specific function of this gene is not yet known. [provided by RefSeq, Jul 2008] (from NCBI)
Papers using period 2 antibodies
A transcription factor response element for gene expression during circadian night.
Yamazaki Shin, In PLoS ONE, 2001
... Per2::dLuc transgenic rats were generated in ...
Papers on period 2
Effects of aging and genotype on circadian rhythms, sleep, and clock gene expression in APPxPS1 knock-in mice, a model for Alzheimer's disease.
O'Hara et al., Lexington, United States. In Exp Neurol, 2012
Expression of period 2 transgene in the suprachiasmatic nucleus is affected by zeitgeber time (ZT) with a marginal interaction effect of age, genotype, and ZT.
Fibroblast circadian rhythms of PER2 expression depend on membrane potential and intracellular calcium.
Welsh et al., San Diego, United States. In Chronobiol Int, 2012
PER2 expression in Fibroblast of suprachiasmatic nucleus depends on membrane potential and intracellular calcium.
A Period 2 genetic variant interacts with plasma SFA to modify plasma lipid concentrations in adults with metabolic syndrome.
Lopez-Miranda et al., Córdoba, Spain. In J Nutr, 2012
the rs2304672 polymorphism in the PER2 gene locus may influence lipid metabolism by interacting with the plasma total SFA concentration in participants with MetS.
Loss of mPer2 increases plasma insulin levels by enhanced glucose-stimulated insulin secretion and impaired insulin clearance in mice.
Zhang et al., Nanjing, China. In Febs Lett, 2012
mPer2 plays a role in regulation of circulating insulin levels
Adora2b-elicited Per2 stabilization promotes a HIF-dependent metabolic switch crucial for myocardial adaptation to ischemia.
Eltzschig et al., Aurora, United States. In Nat Med, 2012
studies identify adenosine-elicited stabilization of Per2 in the control of HIF-dependent cardiac metabolism and ischemia tolerance and implicate Per2 stabilization
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