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Period homolog 2

period 2, Per2, mPer2
This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. Circadian expression in the suprachiasmatic nucleus continues in constant darkness, and a shift in the light/dark cycle evokes a proportional shift of gene expression in the suprachiasmatic nucleus. The specific function of this gene is not yet known. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CLOCK, HAD, AGE, CAN, Tic
Papers using period 2 antibodies
A transcription factor response element for gene expression during circadian night.
Yamazaki Shin, In PLoS ONE, 2001
... Per2::dLuc transgenic rats were generated in ...
Papers on period 2
Changing Dutch approach and trends in short-term outcome of periviable preterms.
Groenendaal et al., Nijmegen, Netherlands. In Arch Dis Child Fetal Neonatal Ed, Feb 2016
MAIN OUTCOME MEASURES: Neonatal intensive care unit (NICU) admission, live births, neonatal in-hospital mortality, morbidity and favourable outcome (no mortality or morbidity) before (2000-2005; period 1) and after (2007-2011; period 2) introduction of the modified guideline, using χ(2) tests and univariable and multivariable logistic regression analyses.
Sequential Treatment Initiation with Timothy Grass and Ragweed Sublingual Immunotherapy Tablets Followed by Simultaneous Treatment Is Well Tolerated.
Nolte et al., Québec, Canada. In J Allergy Clin Immunol Pract, Feb 2016
In period 2, subjects received a short ragweed SLIT tablet (12 Ambrosia artemisiifolia 1-U; Merck/ALK) every morning and a grass SLIT tablet every evening.
Staphylococcus aureus Bacteremia in Children: Changes During Eighteen Years.
Figueras-Nadal et al., Barcelona, Spain. In Pediatr Infect Dis J, Dec 2015
Four study periods were established: period 1, 1995-1999; period 2, 2000-2002; period 3, 2006-2008 and period 4, 2010-2012.
Circadian Clock Genes Modulate Human Bone Marrow Mesenchymal Stem Cell Differentiation, Migration and Cell Cycle.
Larghero et al., Paris, France. In Plos One, Dec 2015
To that, we used both a chemical approach with a GSK-3β specific inhibitor (2'E,3'Z-6-bromoindirubin-3'-oxime, BIO) and a knockdown of CLOCK and PER2, two of the main genes involved in CR regulation.
Calcium and SOL Protease Mediate Temperature Resetting of Circadian Clocks.
Emery et al., Worcester, United States. In Cell, Dec 2015
Interestingly, downregulating the mammalian SOL homolog SOLH blocks thermal mPER2 degradation and phase shifts.
Circadian molecular clock in lung pathophysiology.
Rahman et al., Rochester, United States. In Am J Physiol Lung Cell Mol Physiol, Dec 2015
The deacetylase Sirtuin 1 (SIRT1) regulates the timing of the clock through acetylation of BMAL1 and PER2 and controls the clock-dependent functions, which can also be affected by environmental stressors.
Circadian Clock Control by Polyamine Levels through a Mechanism that Declines with Age.
Asher et al., Israel. In Cell Metab, Dec 2015
In turn, polyamines control the circadian period in cultured cells and animals by regulating the interaction between the core clock repressors PER2 and CRY1.
Circadian clock-coupled lung cellular and molecular functions in chronic airway diseases.
Rahman et al., Rochester, United States. In Am J Respir Cell Mol Biol, Sep 2015
Stress-mediated post-translational modification of molecular clock proteins, brain and muscle aryl hydrocarbon receptor nuclear translocator-like 1 (BMAL1) and PERIOD 2, is associated with a reduction in the activity/level of the deacetylase sirtuin 1 (SIRT1).
Change of fatty acid composition of the lumbar longissimus during the final stage of fattening in the Japanese Black cattle.
Oyama et al., Kōbe, Japan. In Anim Sci J, Sep 2015
The increasing rate of MUFA rose from 0.21 percentage points (pp)/month at period 1 (from the first sampling to the second sampling) to 0.84 pp/month at period 2 (from the second sampling to the slaughter).
Clock genes in human alcohol abuse and comorbid conditions.
Partonen, Helsinki, Finland. In Alcohol, Jun 2015
Concerning alcohol use, the current findings give support, but are preliminary to, the associations of ARNTL (BMAL1) rs6486120 with alcohol consumption, ARNTL2 rs7958822 and ARNTL2 rs4964057 with alcohol abuse, and PER1 rs3027172 and PER2 rs56013859 with alcohol dependence.
Multiplicity of hypoxia-inducible transcription factors and their connection to the circadian clock in the zebrafish*.
Egg et al., Innsbruck, Austria. In Physiol Biochem Zool, Mar 2015
Here we show that Hif-1α also binds to the promoter of the period 2 gene, indicating that multiple connections between the Hif signaling pathway and the circadian clock exist.
Summer-Long Grazing of High vs. Low Endophyte (Neotyphodium coenophialum)-Infected Tall Fescue by Growing Beef Steers Results in Distinct Temporal Blood Analyte Response Patterns, with Poor Correlation to Serum Prolactin Levels.
Matthews et al., Lexington, United States. In Front Vet Sci, 2014
We now report the temporal development of acute, intermediate, and chronic responses of biochemical and clinical blood analytes determined at specified time intervals (period 1, day 0-36; period 2, day 37-58; and period 3, day 59-85).
Breast cancer screening using tomosynthesis in combination with digital mammography.
Conant et al., Philadelphia, United States. In Jama, 2014
EXPOSURES: Period 1: digital mammography screening examinations 1 year before tomosynthesis implementation (start dates ranged from March 2010 to October 2011 through the date of tomosynthesis implementation); period 2: digital mammography plus tomosynthesis examinations from initiation of tomosynthesis screening (March 2011 to October 2012) through December 31, 2012.
Interaction of circadian clock proteins CRY1 and PER2 is modulated by zinc binding and disulfide bond formation.
Wolf et al., München, Germany. In Cell, 2014
To define the roles of mammalian CRY/PER complexes in the circadian clock, we have determined the crystal structure of a complex comprising the photolyase homology region of mouse CRY1 (mCRY1) and a C-terminal mouse PER2 (mPER2) fragment.
Adjustment of therapy in rheumatoid arthritis on the basis of achievement of stable low disease activity with adalimumab plus methotrexate or methotrexate alone: the randomised controlled OPTIMA trial.
Kavanaugh et al., Vienna, Austria. In Lancet, 2014
Patients in the adalimumab plus methotrexate group who completed period 1 and achieved the stable low disease activity target (28-joint disease activity score with C-reactive protein [DAS28]<3·2 at weeks 22 and 26) were randomised to adalimumab-continuation or adalimumab-withdrawal for an additional 52 weeks (period 2).
Effects of aging and genotype on circadian rhythms, sleep, and clock gene expression in APPxPS1 knock-in mice, a model for Alzheimer's disease.
O'Hara et al., Lexington, United States. In Exp Neurol, 2012
Expression of period 2 transgene in the suprachiasmatic nucleus is affected by zeitgeber time (ZT) with a marginal interaction effect of age, genotype, and ZT.
A Period 2 genetic variant interacts with plasma SFA to modify plasma lipid concentrations in adults with metabolic syndrome.
Lopez-Miranda et al., Córdoba, Spain. In J Nutr, 2012
the rs2304672 polymorphism in the PER2 gene locus may influence lipid metabolism by interacting with the plasma total SFA concentration in participants with MetS.
Fibroblast circadian rhythms of PER2 expression depend on membrane potential and intracellular calcium.
Welsh et al., San Diego, United States. In Chronobiol Int, 2012
PER2 expression in Fibroblast of suprachiasmatic nucleus depends on membrane potential and intracellular calcium.
Loss of mPer2 increases plasma insulin levels by enhanced glucose-stimulated insulin secretion and impaired insulin clearance in mice.
Zhang et al., Nanjing, China. In Febs Lett, 2012
mPer2 plays a role in regulation of circulating insulin levels
Adora2b-elicited Per2 stabilization promotes a HIF-dependent metabolic switch crucial for myocardial adaptation to ischemia.
Eltzschig et al., Aurora, United States. In Nat Med, 2012
studies identify adenosine-elicited stabilization of Per2 in the control of HIF-dependent cardiac metabolism and ischemia tolerance and implicate Per2 stabilization
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