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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Perilipin 1

Perilipin, perilipin A, PLIN, CAB2, Lhcb1
The protein encoded by this gene coats lipid storage droplets in adipocytes, thereby protecting them until they can be broken down by hormone-sensitive lipase. The encoded protein is the major cAMP-dependent protein kinase substrate in adipocytes and, when unphosphorylated, may play a role in the inhibition of lipolysis. Alternatively spliced transcript variants varying in the 5' UTR, but encoding the same protein, have been found for this gene. [provided by RefSeq, Feb 2009] (from NCBI)
Top mentioned proteins: ACID, Insulin, fibrillin-1, CAN, HAD
Papers on Perilipin
Effect of Interaction between PLIN Gene Polymorphisms and Open Lifestyle Intervention on Weight-loss in Chinese Han Adults.
Chang et al., Beijing, China. In Zhongguo Yi Xue Ke Xue Yuan Xue Bao, Jan 2016
Objective To explore the effect of the interaction between PLIN gene polymorphisms and open lifestyle intervention on weight-loss in Chinese Han adults.
Functional relationship between mTERF4 and GUN1 in retrograde signaling.
Leister et al., Martinsried, Germany. In J Exp Bot, Jan 2016
Comparative analysis revealed that in gun1 and coe1/mterf4, but not in wild-type, gun4, or gun5 plants, the processing of plastid transcripts and expression levels of Lhcb1 mRNA were affected in opposite ways when plants were grown in the presence of LIN or SPE.
Allogeneic adipose-derived stem cells promote survival of fat grafts in immunocompetent diabetic rats.
Liu et al., Shanghai, China. In Cell Tissue Res, Jan 2016
Fat samples were harvested to evaluate the levels of injury and vascularization as shown by perilipin A, CD34 and VEGF at 14 days.
Effects of immobilization and aerobic training on proteins related to intramuscular substrate storage and metabolism in young and older men.
Helge et al., Copenhagen, Denmark. In Eur J Appl Physiol, Jan 2016
The biopsies were analyzed for muscle substrates; muscle perilipin protein (PLIN), glycogen synthase (GS), synaptosomal-associated protein of 23 kDa (SNAP23) protein content, and muscle 3-hydroxyacyl-CoA dehydrogenase (HAD) activity RESULTS: The older men had higher intramuscular triglyceride (IMTG) (73 %) and Glycogen (16 %) levels compared to the young men, and IMTG tended to increase with immobilization.
Endogenous and Synthetic ABHD5 Ligands Regulate ABHD5-Perilipin Interactions and Lipolysis in Fat and Muscle.
Granneman et al., Detroit, United States. In Cell Metab, Dec 2015
Fat and muscle lipolysis involves functional interactions of adipose triglyceride lipase (ATGL), α-β hydrolase domain-containing protein 5 (ABHD5), and tissue-specific perilipins 1 and 5 (PLIN1 and PLIN5).
Topiramate effects lipolysis in 3T3-L1 adipocytes.
DE Souza et al., Criciúma, Brazil. In Biomed Rep, Nov 2015
The phosphorylation of protein kinase A (PKA), hormone-sensitive lipase (HSL), adipocyte triglyceride lipase (ATGL) and perilipin A, as well as the protein levels of comparative genetic identification 58 (CGI-58) were assessed.
Pathophysiology of lipid droplet proteins in liver diseases.
Ahima et al., Philadelphia, United States. In Exp Cell Res, Nov 2015
Five proteins of the perilipin (PLIN) family (PLIN1 (perilipin), PLIN2 (adipose differentiation-related protein), PLIN3 (tail-interacting protein of 47kDa), PLIN4 (S3-12), and PLIN5 (myocardial lipid droplet protein)), are associated with LD formation.
Piecing together the puzzle of perilipin proteins and skeletal muscle lipolysis.
Peters et al., Canada. In Appl Physiol Nutr Metab, Jul 2015
The absence of PLIN1 in skeletal muscle leads us to believe that other PLIN family members undertake this role.
Unraveling the roles of PLIN5: linking cell biology to physiology.
Watt et al., Australia. In Trends Endocrinol Metab, Mar 2015
The discovery of perilipin (PLIN) 1 provided a major conceptual shift in the understanding of adipose tissue lipolysis and generated intense interest in lipid droplet biology research.
Compartmentalization of cAMP signaling in adipogenesis, lipogenesis, and lipolysis.
Taskén et al., Oslo, Norway. In Horm Metab Res, 2014
This review will provide an updated overview of some of the sites of regulation by cAMP in adipogenesis and lipolysis and the involvement of AKAPs and highlighting, as a recent example, the AKAP Optical Atrophy 1 (OPA1) and its role in the phosphorylation of Perilipin to induce lipolysis.
Regulation of adipocyte lipolysis.
Rodríguez et al., Pamplona, Spain. In Nutr Res Rev, 2014
Perilipin, comparative gene identification-58 (CGI-58) and other proteins of the lipid droplet surface are currently known to be key regulators of the lipolytic machinery, protecting or exposing the TAG core of the droplet to lipases.
Reduced mRNA and protein expression of perilipin A and G0/G1 switch gene 2 (G0S2) in human adipose tissue in poorly controlled type 2 diabetes.
Møller et al., Århus, Denmark. In J Clin Endocrinol Metab, 2012
Reduced mRNA and protein content of Plin and G0S2 and borderline increased ATGL protein in sc adipose tissue from poorly controlled type 2 diabetic subjects.
The cortisol awakening response is related with PERIOD1 clock gene expression in older women.
Dittmar et al., Kiel, Germany. In Exp Gerontol, 2012
The morning cortisol increase as indicated by CAR correlated positively and significantly with hPER1 gene expression in older women suggesting that hPER1 expression increases in response to the morning cortisol increase in older women
Deletion of the C-terminal phosphorylation sites in the cardiac β-subunit does not affect the basic β-adrenergic response of the heart and the Ca(v)1.2 channel.
Hofmann et al., München, Germany. In J Biol Chem, 2012
We conclude that phosphorylation of the C-terminal sites in Ca(v)beta(2), Ser(1928), Ser(1512), and Ser(1570) of the Ca(v)1.2 protein is functionally not involved in the adrenergic regulation of the murine cardiac Ca(v)1.2 channel.
Conjugated linoleic acid supplementation caused reduction of perilipin1 and aberrant lipolysis in epididymal adipose tissue.
Yang et al., Zhengzhou, China. In Biochem Biophys Res Commun, 2012
the reduction of perilipin1 in white adipose tissues may at least in part contribute to conjugated linoleic acid -mediated alternation of lipolysis of white adipose tissues.
Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration.
Lazar et al., Philadelphia, United States. In Nat Med, 2012
Perilipin 2, which coats lipid droplets, is markedly induced upon Hdac3 depletion and contributes to the development of both steatosis and improved tolerance to glucose.
Ahnak1 interaction is affected by phosphorylation of Ser-296 on Cavβ₂.
Haase et al., Berlin, Germany. In Biochem Biophys Res Commun, 2012
phosphorylation event is one mechanism underlying ahnak1's modulator function on Cav1.2 channel activity.
Perilipin deficiency and autosomal dominant partial lipodystrophy.
Vigouroux et al., Cambridge, United Kingdom. In N Engl J Med, 2011
Identified two heterozygous frameshift mutations in the perilipin gene (PLIN1) in three families with partial lipodystrophy, severe dyslipidemia, and insulin-resistant diabetes; findings define a novel dominant form of inherited lipodystrophy.
PERILIPIN-dependent control of lipid droplet structure and fat storage in Drosophila.
Kühnlein et al., Göttingen, Germany. In Cell Metab, 2010
Here, we show that Drosophila mutants lacking the PERILIPIN PLIN1 are hyperphagic and suffer from adult-onset obesity.
Absence of perilipin results in leanness and reverses obesity in Lepr(db/db) mice.
Chan et al., Houston, United States. In Nat Genet, 2000
Perilipin (encoded by the gene Plin), an adipocyte protein, has been postulated to modulate HSL activity.
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