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Peptidylprolyl isomerase A

Peptidylprolyl Isomerase, cyclophilin A, CypA
This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, CIs, CsA, V1a, ACID
Papers using Peptidylprolyl Isomerase antibodies
Ubiquitin is covalently attached to the p6Gag proteins of human immunodeficiency virus type 1 and simian immunodeficiency virus and to the p12Gag protein of Moloney murine leukemia virus.
Früh Klaus, In PLoS Pathogens, 1997
... Rabbit polyclonal antibody against cyclophilin A (SA-296) was obtained from Biomol (Plymouth Meeting, Pennsylvania) and ...
Macrophages and atherosclerotic plaque stability
Lee Won-Ha et al., In Mediators of Inflammation, 1995
... Recombinant human CypA was purchased from BIOMOL International (USA) ...
Papers on Peptidylprolyl Isomerase
Role of protein phosphatases in the run-down of guinea-pig cardiac Cav1.2 Ca2+ channels.
Kameyama et al., China. In Am J Physiol Cell Physiol, Feb 2016
But protein phosphatase type 2B (PP2B, calcineurin) inhibitor, cyclosporine A together with cyclophilin A had no effect on the channel run-down.
PPIA rs6850: A > G single-nucleotide polymorphism is associated with raised plasma cyclophilin A levels in patients with coronary artery disease.
Ramachandran et al., Thiruvananthapuram, India. In Mol Cell Biochem, Jan 2016
Genetic variants in the peptidylprolyl isomerase A gene, encoding human cyclophilin may alter protein synthesis thus affecting its activity, function, and circulating plasma levels.
Enhanced molecular dynamics sampling of drug target conformations.
Hamelberg et al., Atlanta, United States. In Biopolymers, Jan 2016
RaMD-db is shown to be able to generate a broad distribution of structures of a drug target, Cyclophilin A. These structures that have never been observed previously in very long conventional MD can be further used for structure-based computer-aided drug discovery, and docking, and thus, in the identification and design of potential novel inhibitors.
Rapamycin rescues vascular, metabolic and learning deficits in apolipoprotein E4 transgenic mice with pre-symptomatic Alzheimer's disease.
Richardson et al., San Antonio, United States. In J Cereb Blood Flow Metab, Jan 2016
We also found that rapamycin restored the levels of the proinflammatory cyclophilin A in vasculature, which may contribute to the preservation of cerebrovascular function in the apolipoprotein E ɛ4 transgenics.
Efficient and powerful method for combining p-values in Genome-wide Association Studies.
Calle et al., In Ieee/acm Trans Comput Biol Bioinform, Jan 2016
Specifically, the globalEVT method is able to detect genes related to Cyclophilin A like domain proteins which is known to play an important role in the mechanisms of ADHD development.
Selective inhibition of the mitochondrial permeability transition pore protects against neuro-degeneration in experimental multiple sclerosis.
Selwood et al., London, United Kingdom. In J Biol Chem, Jan 2016
The peptidylprolyl isomerase, cyclophilin D (CypD, ppif) is a positive regulator of the pore and genetic downregulation or knockout improves outcomes in disease models.
Genetic deficiency and polymorphisms of cyclophilin A reveal its essential role for Human Coronavirus 229E replication.
Carbajo-Lozoya et al., München, Germany. In Curr Opin Virol, Oct 2015
Here, we summarize present knowledge on the role of cyclophilin A during coronavirus replication.
Cyclophilin polymorphism and virus infection.
Ciesek et al., Hannover, Germany. In Curr Opin Virol, Oct 2015
Several coding and non-coding genetic variants in the PPIA gene encoding for CypA have been described, but there is only limited information about their influence on the course of viral infection.
The innate immune roles of host factors TRIM5α and Cyclophilin A on HIV-1 replication.
Zheng et al., Kaifeng, China. In Med Microbiol Immunol, Oct 2015
Innate immune factor TRIM5α and host peptidyl-prolyl cis-trans isomerase Cyclophilin A are two key players in the interaction between HIV-1 and host.
The Cyclophilin A-CD147 complex promotes the proliferation and homing of multiple myeloma cells.
Carrasco et al., Boston, United States. In Nat Med, Jun 2015
We found that extracellular CyPA (eCyPA), secreted by bone marrow endothelial cells (BMECs), promoted the colonization and proliferation of MM cells in an in vivo scaffold system via binding to its receptor, CD147, on MM cells.
Keep on moving: discovering and perturbing the conformational dynamics of enzymes.
Fraser et al., San Francisco, United States. In Acc Chem Res, Mar 2015
Examples are the catalytic cycles of dihydrofolate reductase (DHFR) and cyclophilin A (CypA).
[Novel methods of hepatitis C treatment and prevention].
Bieńkowska-Szewczyk et al., Laizhou, China. In Postepy Hig Med Dosw (online), 2014
Numerous novel anti-HCV compounds have been evaluated in advanced clinical trials including inhibitors of viral proteins (protease, polymerase and NS5A) and inhibitors of host factors involved in HCV replication (cyclophilin A, microRNA - miR-122).
Antifungal drug resistance evoked via RNAi-dependent epimutations.
Heitman et al., Durham, United States. In Nature, 2014
The peptidylprolyl isomerase FKBP12 interacts with FK506 forming a complex that inhibits the protein phosphatase calcineurin.
Making sense of HIV innate sensing.
Siliciano et al., Baltimore, United States. In Immunity, 2014
In this issue of Immunity, Lahaye et al. (2013) demonstrate that HIV capsid-cyclophilin A interactions affect viral cDNA sensing by the DNA sensor cCAS and contribute to differential pathogenesis of HIV-1 and HIV-2.
HIV-1 evades innate immune recognition through specific cofactor recruitment.
Towers et al., London, United Kingdom. In Nature, 2013
Here we show that HIV-1 capsid mutants N74D and P90A, which are impaired for interaction with cofactors cleavage and polyadenylation specificity factor subunit 6 (CPSF6) and cyclophilins (Nup358 and CypA), respectively, cannot replicate in primary human monocyte-derived macrophages because they trigger innate sensors leading to nuclear translocation of NF-κB and IRF3, the production of soluble type 1 IFN and induction of an antiviral state.
Hepatocytes that express variants of cyclophilin A are resistant to HCV infection and replication.
Ciesek et al., Hannover, Germany. In Gastroenterology, 2012
We identified variants in PPIA that destabilize its product, CypA, and prevent HCV infection and replication.
Insights into pediatric diffuse intrinsic pontine glioma through proteomic analysis of cerebrospinal fluid.
Nazarian et al., Washington, D.C., United States. In Neuro Oncol, 2012
High Cyclophilin A is associated with pediatric diffuse intrinsic pontine glioma.
Cyclophilin A is required for efficient human cytomegalovirus DNA replication and reactivation.
St Jeor et al., Reno, United States. In J Gen Virol, 2012
an important factor in cytomegalovirus IE protein expression and virus production
A major prolactin-binding complex on human milk fat globule membranes contains cyclophilins A and B: the complex is not the prolactin receptor.
Walker et al., Riverside, United States. In Am J Physiol Endocrinol Metab, 2012
First report of a unique, multicomponent, high-capacity milk fat reservoir of prolactin as a bilayer-bound complex with cyclophilins A and B in human milk.
[Clinical significance of MRP8 and cypA expression in laryngeal squamous cell carcinoma tissues].
Dong et al., Chongqing, China. In Lin Chuang Er Bi Yan Hou Ke Za Zhi, 2011
CypA protein may play an important role in the development and progression of laryngeal squamous cell carcinoma.
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