Growth curves and age-related changes in carcass characteristics, organs, serum parameters, and intestinal transporter gene expression in domestic pigeon (Columba livia).
Guangzhou, China. In Poult Sci, Feb 2016
Furthermore, the gene expressions of nutrient transporters (y(+)LAT2, LAT1, B0AT1, PepT1, and NHE2) in jejunum of pigeon were increased with age.
The relevance of JAK2 in the regulation of cellular transport.
Pristina, Serbia. In Curr Med Chem, Jan 2016
As a powerful regulator of transport mechanisms across the cell membrane, JAK2 regulates a wide variety of potassium, calcium, sodium and chloride ion channels, multiple Na+-coupled cellular carriers including EAAT1-4, NaPi-IIa, SGLT1, BoaT1, PepT1-2, CreaT1, SMIT1, and BGT1 as well as Na+/K+-ATPase.
Expression of small intestinal nutrient transporters in embryonic and posthatch turkeys.
Edinburgh, United Kingdom. In Poult Sci, Dec 2015
Real-time PCR was used to determine expression of aminopeptidase N (APN), one peptide (PepT1), 6 amino acid (ASCT1, b(o,+)AT, CAT1, EAAT3, LAT1, y(+)LAT2) and 3 monosaccharide (GLUT2, GLUT5, SGLT1) transporters.
Molecular insights into proton coupled peptide transport in the PTR family of oligopeptide transporters.
Oxford, United Kingdom. In Biochim Biophys Acta, Mar 2015
GENERAL SIGNIFICANCE: Physiological studies on PepT1 and PepT2, the mammalian members of this family, have identified these transporters as being responsible for the uptake of many pharmaceutically important drug molecules, including antibiotics and antiviral medications and demonstrated their promiscuity can be used for improving the oral bioavailability of poorly absorbed compounds.
Interaction of Drug or Food with Drug Transporters in Intestine and Liver.
Kanazawa, Japan. In Curr Drug Metab, 2014
Among those transporters, this review will focus on PEPT1 and OATP2B1 as influx transporter and p-glycoprotein (P-gp) and BCRP as efflux transporter in intestinal epithelial cells, and on OATP1B1 and 1B3 as influx transporter and MRP2 as efflux transporter in hepatocytes, respectively, because drug-drug (DDI) and -food (DFI) interactions on these transporter are considered to affect bioavailability of their substrate drugs.