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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Solute carrier family 15

PEPT1, hPepT1
This gene encodes an intestinal hydrogen peptide cotransporter that is a member of the solute carrier family 15. The encoded protein is localized to the brush border membrane of the intestinal epithelium and mediates the uptake of di- and tripeptides from the lumen into the enterocytes. This protein plays an important role in the uptake and digestion of dietary proteins. This protein also facilitates the absorption of numerous peptidomimetic drugs. [provided by RefSeq, Apr 2010] (from NCBI)
Top mentioned proteins: ACID, V1a, SAR, CAN, HAD
Papers on PEPT1
Growth curves and age-related changes in carcass characteristics, organs, serum parameters, and intestinal transporter gene expression in domestic pigeon (Columba livia).
New
Wang et al., Guangzhou, China. In Poult Sci, Feb 2016
Furthermore, the gene expressions of nutrient transporters (y(+)LAT2, LAT1, B0AT1, PepT1, and NHE2) in jejunum of pigeon were increased with age.
Effect of N-glycosylation on the transport activity of the peptide transporter PEPT1.
New
Daniel et al., Freising, Germany. In Am J Physiol Gastrointest Liver Physiol, Feb 2016
The intestinal peptide transporter PEPT1 provides bulk quantities of amino acids to epithelial cells.
The proton-coupled oligopeptide transporter 1 plays a major role in the intestinal permeability and absorption of 5-aminolevulinic acid.
New
Smith et al., Ann Arbor, United States. In Br J Pharmacol, Jan 2016
In the present study, the intestinal permeability and oral pharmacokinetics of 5-ALA were evaluated to probe the contribution of the proton-coupled oligopeptide transporter 1 (PEPT1) to the oral absorption and systemic exposure of this substrate.
Egg storage duration and hatch window affect gene expression of nutrient transporters and intestine morphological parameters of early hatched broiler chicks.
New
Gucluer et al., İzmir, Turkey. In Animal, Jan 2016
This study was conducted to determine the effects of egg storage duration before incubation and hatch window on intestinal development and expression of PepT1 (H+-dependent peptide transporter) and SGLT1 (sodium-glucose co-transporter) genes in the jejunum of early hatched broiler chicks within a 30 h of hatch window.
The relevance of JAK2 in the regulation of cellular transport.
Review
New
Dërmaku-Sopjani et al., Pristina, Serbia. In Curr Med Chem, Jan 2016
As a powerful regulator of transport mechanisms across the cell membrane, JAK2 regulates a wide variety of potassium, calcium, sodium and chloride ion channels, multiple Na+-coupled cellular carriers including EAAT1-4, NaPi-IIa, SGLT1, BoaT1, PepT1-2, CreaT1, SMIT1, and BGT1 as well as Na+/K+-ATPase.
Taste and move: glucose and peptide transporters in the gastrointestinal tract.
Review
New
Zietek et al., Freising, Germany. In Exp Physiol, Jan 2016
While glucose absorption is mediated by the Na(+) -dependent SGLT1 protein, uptake of short-chain peptides is mediated by the H(+) -coupled PEPT1 protein.
Possible interaction of quinolone antibiotics with peptide transporter 1 in oral absorption of peptide-mimetic drugs.
New
Ogihara et al., Takasaki, Japan. In Biopharm Drug Dispos, Dec 2015
UNASSIGNED: We investigated whether quinolone antibiotics inhibit PEPT1-mediated uptake of its substrates.
Expression of small intestinal nutrient transporters in embryonic and posthatch turkeys.
New
Wong et al., Edinburgh, United Kingdom. In Poult Sci, Dec 2015
Real-time PCR was used to determine expression of aminopeptidase N (APN), one peptide (PepT1), 6 amino acid (ASCT1, b(o,+)AT, CAT1, EAAT3, LAT1, y(+)LAT2) and 3 monosaccharide (GLUT2, GLUT5, SGLT1) transporters.
Enhancement effect of resveratrol on the intestinal absorption of bestatin by regulating PEPT1, MDR1 and MRP2 in vivo and in vitro.
New
Liu et al., Dalian, China. In Int J Pharm, Dec 2015
Res facilitated bestatin absorption by down-regulating both protein and gene levels of multidrug resistance 1 (Mdr1) and Multidrug resistance-associated protein 2 (Mrp2), and up-regulating oligopeptide transporter 1 (Pept1) protein and mRNA expression in rat intestine.
Dosage Effect of Zinc Glycine Chelate on Zinc Metabolism and Gene Expression of Zinc Transporter in Intestinal Segments on Rat.
New
Feng et al., Hangzhou, China. In Biol Trace Elem Res, Nov 2015
In the duodenum, adding 60 or 90 mg Zn/kg increased PepT1 expression, but in the jejunum, 60 mg Zn/kg did not differ from 0 added Zn.
Intriguing possibilities and beneficial aspects of transporter-conscious drug design.
Review
New
Tashima, Ōsaka, Japan. In Bioorg Med Chem, Sep 2015
In fact, based on this strategy, the bioavailability of prodrugs designed as peptide transporter 1 (PEPT1) substrates was better than that of the corresponding parent compounds due to the transport system in the small intestine.
Inhibition on JAK-STAT3 Signaling Transduction Cascade Is Taken by Bioactive Peptide Alpha-S2 Casein Protein from Goat Ethawah Breed Milk.
New
Fatchiyah et al., Malang, Indonesia. In Acta Inform Med, Aug 2015
Based on in silico study, from eight peptides, only three peptides of CSN1S2 protein, which carried by PePT1 to enter the small intestine.
Interaction of Drug or Food with Drug Transporters in Intestine and Liver.
Review
Tamai et al., Kanazawa, Japan. In Curr Drug Metab, 2014
Among those transporters, this review will focus on PEPT1 and OATP2B1 as influx transporter and p-glycoprotein (P-gp) and BCRP as efflux transporter in intestinal epithelial cells, and on OATP1B1 and 1B3 as influx transporter and MRP2 as efflux transporter in hepatocytes, respectively, because drug-drug (DDI) and -food (DFI) interactions on these transporter are considered to affect bioavailability of their substrate drugs.
PepT1, ASBT-Linked Prodrug Strategy to Improve Oral Bioavailability and Tissue Targeting Distribution.
Review
He et al., Shenyang, China. In Curr Drug Metab, 2014
This article focuses on the design of transporter-linked prodrug to enhance oral bioavailability and to acquire tissue-specific distribution pattern, especially paying attention to peptide transporter 1 (PepT1) and apical sodium dependent bile acid transporter (ASBT).
Influence of fed-fasted state on intestinal PEPT1 expression and in vivo pharmacokinetics of glycylsarcosine in wild-type and Pept1 knockout mice.
GeneRIF
Smith et al., Ann Arbor, United States. In Pharm Res, 2012
Expression of PEPT1 protein in the small intestine was increased ~2-fold in wild-type mice during fasted as compared to fed conditions.
The PepT1-NOD2 signaling pathway aggravates induced colitis in mice.
GeneRIF
Merlin et al., Atlanta, United States. In Gastroenterology, 2011
The PepT1-NOD2 signaling pathway is involved in aggravation of colitis in mice.
Amino acid absorption and homeostasis in mice lacking the intestinal peptide transporter PEPT1.
GeneRIF
Daniel et al., Freising, Germany. In Am J Physiol Gastrointest Liver Physiol, 2011
PEPT1 is important for overall amino acid absorption only after high dietary protein intake when amino acid transport processes are saturated and PEPT1 can provide additional absorption capacity.
Proton-coupled oligopeptide transporter (POT) family expression in human nasal epithelium and their drug transport potential.
GeneRIF
Massoud et al., Halifax, Canada. In Mol Pharm, 2011
PEPT1,PEPT2, PHT1, and PHT2 are expressed in human nasal epithelium.
The intestinal peptide transporter PEPT1 is involved in food intake regulation in mice fed a high-protein diet.
GeneRIF
Daniel et al., Freising, Germany. In Plos One, 2010
The intestinal peptide transporter PEPT1 is involved in food intake regulation in mice fed a high-protein diet.
Expression cloning of a mammalian proton-coupled oligopeptide transporter.
Impact
Hediger et al., Boston, United States. In Nature, 1994
This new protein, named PepT1, displays an unusually broad substrate specificity.
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