Upregulation of RHOXF2 and ODF4 Expression in Breast Cancer Tissues.
Tehrān, Iran. In Cell J, 2014
MATERIALS AND METHODS: In this applied-descriptive study, the expression of 4 CTAs, namely acrosin binding protein (ACRBP), outer dense fiber 4 (ODF4), Rhox homeobox family member 2 (RHOXF2) and spermatogenesis associated 19 (SPATA19) were ana- lyzed at the transcript level in two breast cancer lines (MCF-7 and MDA-MB-231), 40 invasive ductal carcinoma samples and their adjacent normal tissues as well as 10 fibroadenoma samples by means of quantitative real-time reverse transcription polymerase chain reaction (RT-PCR).
Are so-called cancer-testis genes expressed only in testis?
Tehrān, Iran. In Asian Pac J Cancer Prev, 2013
Here we analyzed expression of two previously known CT antigens, RHOXF2 and PIWIL2, in AML patients versus normal donors and found no significant difference in the expression of these genes between the two groups.
Genome-wide analysis of cancer/testis gene expression.
Boston, United States. In Proc Natl Acad Sci U S A, 2009
Applying this core classification in a genome-wide survey we identified >30 CT candidate genes; 3 of them, PEPP-2, OTOA, and AKAP4, were confirmed as testis-restricted or testis-selective using RT-PCR, with variable expression frequencies observed in a panel of cancer cell lines.