Apramycin treatment affects selection and spread of a multidrug-resistant Escherichia coli strain able to colonize the human gut in the intestinal microbiota of pigs.
Frederiksberg, Denmark. In Vet Res, Dec 2015
It carried resistance genes to apramycin/gentamicin, sulphonamide, tetracycline, hygromycin B, β-lactams and streptomycin [aac(3)-IV, sul2, tet(X), aph(4), bla TEM-1 and strA/B], with all but tet(X) located on the same conjugative plasmid.
ML302, a Novel Beta-lactamase (BLA) Inhibitor
Bethesda, United States. In Unknown Journal, 2012
Various secondary assays were run to determine its dual potency (VIM-2 IC50 = 548 nM; IMP-1 IC50 = 3.02 μM) and class B selectivity (it was inactive in TEM-1 and AmpC beta-lactamase enzymatic assays).