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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Pellino homolog 3

Pellino3, Pellino3a
The protein encoded by this gene is a scaffold protein and an intermediate signaling protein in the innate immune response pathway. The encoded protein helps transmit the immune response signal from Toll-like receptors to IRAK1/TRAF6 complexes. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011] (from NCBI)
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Papers on Pellino3
Pellino 3b negatively regulates interleukin-1-induced TAK1-dependent NF kappaB activation.
GeneRIF
Li et al., Cleveland, United States. In J Biol Chem, 2008
suggest that Pellino 3b acts as a negative regulator for IL-1 signaling by regulating IRAK degradation through its ubiquitin protein ligase activity [Pellino 3b]
Pellino3 is a novel upstream regulator of p38 MAPK and activates CREB in a p38-dependent manner.
GeneRIF
Moynagh et al., Dublin, Ireland. In J Biol Chem, 2005
Pellino3 is a novel upstream regulator of p38 MAPK that activates CREB in a p38-dependent manner
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