Decorin as a multivalent therapeutic agent against cancer.
Philadelphia, United States. In Adv Drug Deliv Rev, Nov 2015
Upon receptor binding, decorin initiates signaling pathways within endothelial cells downstream of VEGFR2 that ultimately culminate in a Peg3/Beclin 1/LC3-dependent autophagic program.
A systematic review and meta-analysis of DNA methylation levels and imprinting disorders in children conceived by IVF/ICSI compared with children conceived spontaneously.
Aberdeen, United Kingdom. In Hum Reprod Update, 2014
0.49), PEG1-MEST: 0.47 (-2.07, 3.01), GRB10: -0.05 (-0.43, 0.33), IGF2: -0.15 (-1.09, 0.79), SNRPN: -0.55 (-1.55, 0.46), KvDMR/KCNQ10T1: -0.16 (-0.34, 0.02) and PEG3: -0.24 (-1.72, 1.24).
Regulation and function of the peg3 imprinted domain.
Baton Rouge, United States. In Genomics Inform, 2014
A subset of mammalian genes differ functionally between two alleles due to genomic imprinting, and seven such genes (Peg3, Usp29, APeg3, Zfp264, Zim1, Zim2, Zim3) are localized within the 500-kb genomic interval of the human and mouse genomes, constituting the Peg3 imprinted domain.
Role of Tet1 in erasure of genomic imprinting.
Boston, United States. In Nature, 2014
We show that despite their identical genotype, progenies derived from mating between Tet1 knockout males and wild-Peg10 and Peg3, which exhibit aberrant hypermethylation in the paternal allele of differential methylated regions (DMRs).
Imprinting control region (ICR) of the Peg3 domain.
Baton Rouge, United States. In Hum Mol Genet, 2012
Data show that deletion of the Peg3-DMR (Peg3-differentially methylated region) caused global changes in the imprinting and transcription of the Peg3 domain.