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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Serpin peptidase inhibitor, clade F

PEDF, AAP, pigment epithelium-derived factor, alpha2-antiplasmin
This gene encodes a member of the serpin family of serine protease inhibitors. The protein is a major inhibitor of plasmin, which degrades fibrin and various other proteins. Consequently, the proper function of this gene has a major role in regulating the blood clotting pathway. Mutations in this gene result in alpha-2-plasmin inhibitor deficiency, which is characterized by severe hemorrhagic diathesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009] (from NCBI)
Top mentioned proteins: vascular endothelial growth factor, CAN, AGE, HAD, V1a
Papers using PEDF antibodies
Protein translation and cell death: The role of rare tRNAs in biofilm formation and in activating dormant phage killer genes.
Kudla Grzegorz, In PLoS ONE, 2007
... The human full-length PEDF DNA (1257 bp) was codon-optimized for bacterial expression using Genscript OptimumGene™ design platform, which ...
Papers on PEDF
Single-cell activity of freshwater aerobic anoxygenic phototrophic bacteria and their contribution to biomass production.
Del Giorgio et al., Montréal, Canada. In Isme J, Feb 2016
UNASSIGNED: Aerobic anoxygenic phototrophic (AAP) bacteria are photoheterotrophs that despite their low abundances have been hypothesized to play an ecologically and biogeochemically important role in aquatic systems.
Mesenchymal stem cells engineered to secrete pigment epithelium derived factor inhibit tumor metastasis and the formation of malignant ascites in a murine colorectal peritoneal carcinomatosis model.
Cheng et al., Lanzhou, China. In Hum Gene Ther, Feb 2016
In previous work, we demonstrated that pigment epithelium-derived factor (PEDF) antagonized VEGF-A and could repress tumor growth and suppress metastasis in several cancer types.
Proteomics of vitreous in neovascular age-related macular degeneration.
Koss et al., Heidelberg, Germany. In Exp Eye Res, Feb 2016
Using a stringent statistical analysis with implementation of the closed test principle, we were able to identify four proteins that may be involved in the pathophysiology of nAMD: Clusterin, opticin, pigment epithelium-derived factor and prostaglandin-H2 d-isomerase.
Correction: Pigment Epithelium-Derived Factor (PEDF) Expression Induced by EGFRvIII Promotes Self-renewal and Tumor Progression of Glioma Stem Cells.
Park et al., In Plos Biol, Jan 2016
UNASSIGNED: [This corrects the article DOI: 10.1371/journal.pbio.1002152.].
Natural heterogeneity of alpha-2-antiplasmin: functional and clinical consequences.
Uitte de Willige et al., Rotterdam, Netherlands. In Blood, Jan 2016
UNASSIGNED: Human alpha-2-antiplasmin (α2AP, also named α2-plasmin inhibitor) is the main physiological inhibitor of the fibrinolytic enzyme plasmin.
Pigment Epithelium-Derived Factor, a Protective Factor for Photoreceptors in Vivo.
Becerra et al., Bethesda, United States. In Adv Exp Med Biol, Dec 2015
Pigment epithelium-derived factor (PEDF) is a natural protein of the retina with demonstrable neurotrophic properties, found in the interphotoreceptor matrix in intimate contact with photoreceptors.
Neurotrophic Effect of Adipose Tissue-Derived Stem Cells on Erectile Function Recovery by Pigment Epithelium-Derived Factor Secretion in a Rat Model of Cavernous Nerve Injury.
Deng et al., Guangzhou, China. In Stem Cells Int, Dec 2015
The ADSCs steadily secreted detectable pigment epithelium-derived factor (PEDF) in vitro.
Pigment epithelium-derived factor: clinical significance in estrogen-dependent tissues and its potential in cancer therapy.
Chuaire-Noack et al., Bogotá, Colombia. In Iran J Basic Med Sci, Sep 2015
Pigment epithelium-derived factor (PEDF) is a glycoprotein that belongs to the family of non-inhibitory serpins.
Pharmacologic Approaches Against Advanced Glycation End Products (AGEs) in Diabetic Cardiovascular Disease.
Spadaccio et al., Roma, Italy. In Res Cardiovasc Med, May 2015
Compounds with anti-AGEs activity but still not available for clinical scenarios are ALT-946, OPB-9195, tenilsetam, LR-90, TM2002, sRAGE and PEDF.
Adipose Tissue as an Endocrine Organ: An Update on Pro-inflammatory and Anti-inflammatory Microenvironment.
Marešová et al., Praha, Czech Republic. In Prague Med Rep, 2014
Adipose tissue is recognized as an active endocrine organ that produces a number of endocrine substances referred to as "adipokines" including leptin, adiponectin, adipolin, visfatin, omentin, tumour necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), resistin, pigment epithelium-derived factor (PEDF), and progranulin (PGRN) which play an important role in the food intake regulation and significantly influence insulin sensitivity and in some cases directly affect insulin resistance in skeletal muscle, liver, and adipose tissue.
The effects of PEDF on cancer biology: mechanisms of action and therapeutic potential.
Notario et al., Bethesda, United States. In Nat Rev Cancer, 2013
The potent actions of pigment epithelium-derived factor (PEDF) on tumour-associated cells, and its extracellular localization and secretion, stimulated research on this multifunctional serpin.
PEDF is a novel oligodendrogenic morphogen acting on the adult SVZ and corpus callosum.
Pleasure et al., Sacramento, United States. In J Neurosci, 2012
These studies are the first to report oligodendroglial morphogenic, survival, and remyelination-enhancing effects of PEDF.
[Recombinant fragment of pigment epithelium-derived factor (44-77) prevents pathological corneal neovascularization].
Miroshnikov et al., In Bioorg Khim, 2012
PEDF (44-77) suppressed proliferation of endothelial cells by 53% and inhibited endothelial cell tube formation at the concentration of 1 nM.
Common genetic variation in the SERPINF1 locus determines overall adiposity, obesity-related insulin resistance, and circulating leptin levels.
Staiger et al., Tübingen, Germany. In Plos One, 2011
functional common genetic variant in the gene locus encoding PEDF contributes to overall body adiposity, obesity-related insulin resistance, and circulating leptin levels
PEDF and VEGF-A output from human retinal pigment epithelial cells grown on novel microcarriers.
McKay et al., Tucson, United States. In J Biomed Biotechnol, 2011
Show that long-term survival and neurotrophic potential of hRPE cells can be enhanced by FDA-approved plastic-based microcarriers. Growth of hRPE cells on microcarriers led to sustained levels of PEDF and VEGF-A in conditioned media for two months.
PEDF in diabetic retinopathy: a protective effect of oxidative stress.
Zou et al., Shanghai, China. In J Biomed Biotechnol, 2011
This paper highlights the current understanding of probable mechanism of how PEDF blocks deterioration of diabetic retinopathy through its antioxidative properties and application prospects of PEDF as a novel therapeutic target in diabetic retinopathy.
Pigment epithelium-derived factor contributes to insulin resistance in obesity.
Watt et al., Australia. In Cell Metab, 2009
The pigment epithelium-derived factor is a negative regulator of insulin action in obesity.
Pigment epithelium-derived factor regulates the vasculature and mass of the prostate and pancreas.
Crawford et al., Chicago, United States. In Nat Med, 2003
Results identify the angiogenesis inhibitor pigment epithelium-derived factor (PEDF) as a key inhibitor of stromal vasculature and epithelial tissue growth in mouse prostate and pancreas.
Inducer-stimulated Fas targets activated endothelium for destruction by anti-angiogenic thrombospondin-1 and pigment epithelium-derived factor.
Bouck et al., Chicago, United States. In Nat Med, 2002
Here we show that two such inhibitors, thrombospondin-1 and pigment epithelium-derived factor, derive specificity for remodeling vessels from their dependence on Fas/Fas ligand (FasL)-mediated apoptosis to block angiogenesis.
Stimulated platelets use serotonin to enhance their retention of procoagulant proteins on the cell surface.
Alberio et al., Oklahoma City, United States. In Nature, 2002
Here we show that these cells, referred to as 'COAT-platelets', bind additional alpha-granule proteins, including fibrinogen, von Willebrand factor, thrombospondin, fibronectin and alpha2-antiplasmin.
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