Proteomics of vitreous in neovascular age-related macular degeneration.
Heidelberg, Germany. In Exp Eye Res, Feb 2016
Using a stringent statistical analysis with implementation of the closed test principle, we were able to identify four proteins that may be involved in the pathophysiology of nAMD: Clusterin, opticin, pigment epithelium-derived factor and prostaglandin-H2 d-isomerase.
Adipose Tissue as an Endocrine Organ: An Update on Pro-inflammatory and Anti-inflammatory Microenvironment.
Praha, Czech Republic. In Prague Med Rep, 2014
Adipose tissue is recognized as an active endocrine organ that produces a number of endocrine substances referred to as "adipokines" including leptin, adiponectin, adipolin, visfatin, omentin, tumour necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), resistin, pigment epithelium-derived factor (PEDF), and progranulin (PGRN) which play an important role in the food intake regulation and significantly influence insulin sensitivity and in some cases directly affect insulin resistance in skeletal muscle, liver, and adipose tissue.
PEDF in diabetic retinopathy: a protective effect of oxidative stress.
Shanghai, China. In J Biomed Biotechnol, 2011
This paper highlights the current understanding of probable mechanism of how PEDF blocks deterioration of diabetic retinopathy through its antioxidative properties and application prospects of PEDF as a novel therapeutic target in diabetic retinopathy.