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Phosphatidylethanolamine-binding protein 4

PEBP4, phosphatidylethanolamine-binding protein 4, hPEBP4, mPEBP4
The phosphatidylethanolamine (PE)-binding proteins, including PEBP4, are an evolutionarily conserved family of proteins with pivotal biologic functions, such as lipid binding and inhibition of serine proteases (Wang et al., 2004 [PubMed 15302887]).[supplied by OMIM, Dec 2008] (from NCBI)
Top mentioned proteins: Akt, JNK, CAN, ERK, p53
Papers on PEBP4
Increased expression of phosphatidylethanolamine-binding protein 4 (PEBP4) strongly associates with human gliomas grade.
New
Lu et al., Shanghai, China. In J Neurooncol, Feb 2016
UNASSIGNED: Abnormal expression of phosphatidylethanolamine-binding protein 4 (PEBP4) has been found in various types of malignancies.
Phosphatidylethanolamine-binding protein 4 promotes lung cancer cells proliferation and invasion via PI3K/Akt/mTOR axis.
New
Mi et al., Jiangyin, China. In J Thorac Dis, Oct 2015
BACKGROUND: While phosphatidylethanolamine-binding protein 4 (PEBP4) is a key factor in the malignant proliferation and metastasis of tumor cells, the exact regulatory network governing its roles remains unclear.
PEBP4 promoted the growth and migration of cancer cells in pancreatic ductal adenocarcinoma.
New
Liu et al., Shanghai, China. In Tumour Biol, Sep 2015
Phosphatidylethanolamine-binding protein 4 (PEBP4) has been reported to be upregulated in various cancer types.
miR-15b regulates cisplatin resistance and metastasis by targeting PEBP4 in human lung adenocarcinoma cells.
New
Tao et al., Chengdu, China. In Cancer Gene Ther, Apr 2015
Further studies identified phosphatidylethanolamine-binding protein 4 (PEBP4) as a direct and functional target of miR-15b.
Phorbol ester stimulates ethanolamine release from the metastatic basal prostate cancer cell line PC3 but not from prostate epithelial cell lines LNCaP and P4E6.
Rumsby et al., York, United Kingdom. In Br J Cancer, 2014
Ethanolamine released from cells may reduce Cho uptake, regulating the membrane PtdEtn:PtdCho ratio and influencing the action of PtdEtn-binding proteins such as RKIP and the anti-apoptotic hPEBP4.
Downregulation of PEBP4, a target of miR-34a, sensitizes drug-resistant lung cancer cells.
Wu et al., Jiangyin, China. In Tumour Biol, 2014
The aim of this study was to determine the relationship and underlying mechanisms between ectopic expression of phosphatidylethanolamine-binding protein 4 (PEBP4) and cisplatin (DDP)-induced cytotoxicity in the lung cancer cell line A549 to provide an experimental basis for future chemotherapeutic applications involving PEBP4 in human lung cancer.
Phosphatidylethanolamine-binding protein 4 is associated with breast cancer metastasis through Src-mediated Akt tyrosine phosphorylation.
Wang et al., Hangzhou, China. In Oncogene, 2014
Human phosphatidylethanolamine-binding protein 4 (hPEBP4) is a novel member of the PEBP family and functions as an anti-apoptotic molecule.
Human phosphatidylethanolamine-binding protein 4 promoted the radioresistance of human rectal cancer by activating Akt in an ROS-dependent way.
Ding et al., Hangzhou, China. In Plos One, 2013
Human phosphatidylethanolamine-binding protein 4(hPEBP4) is a novel anti-apoptosis molecule associated with the resistance of tumors to apoptotic agents.
Expression of hPEBP4 negatively correlates with estrogen and progesterone receptors in endometrial carcinoma.
Gu et al., Shanghai, China. In J Buon, 2013
PURPOSE: To investigate the expression of human phosphatidylethanolamine- binding protein 4 (hPEBP4) in endometrial carcinoma and its relation with progesterone receptor (PR) and estrogen receptor (ER).
hPEBP4 as a predictive marker for the pathological response of rectal cancer to preoperative radiotherapy.
Wang et al., Hangzhou, China. In Int J Colorectal Dis, 2013
The aim of the present study was to test the human phosphatidylethanolamine-binding protein 4 (hPEBP4) as a predictive marker of tumor response to preoperative radiotherapy in patients with rectal cancer.
PEBP4 enhanced HCC827 cell proliferation and invasion ability and inhibited apoptosis.
Huang et al., Nehe, China. In Tumour Biol, 2013
The purposes of this study were to investigate the effects of phosphatidylethanolamine-binding protein 4 (PEBP4) on the cell growth, proliferation, apoptosis, and invasion of non-small cell lung cancer (NSCLC) cells and to provide evidence for future treatment options for NSCLC.
Rewiring of human lung cell lineage and mitotic networks in lung adenocarcinomas.
Balmain et al., San Francisco, United States. In Nat Commun, 2012
The networks from normal lung show that NKX2-1 is linked to the alveolar type 2 lineage, and identify PEBP4 as a novel marker expressed in alveolar type 2 cells.
Silencing of human phosphatidylethanolamine-binding protein 4 enhances rituximab-induced death and chemosensitization in B-cell lymphoma.
Wang et al., Hangzhou, China. In Plos One, 2012
Human phosphatidylethanolamine-binding protein 4 (hPEBP4) is a novel member of PEBP family and functions as an anti-apoptotic molecule.
Purification, molecular cloning and functional characterization of swine phosphatidylethanolamine-binding protein 4 from seminal plasma.
Ogita et al., Ōtsu, Japan. In Biochem Biophys Res Commun, 2012
In this study, we purified the swine homolog of human PEBP4 (sPEBP4) from swine seminal plasma, cloned the sPEBP4 cDNA and functionally characterized this protein.
PEBP4 gene expression and its significance in invasion and metastasis of non-small cell lung cancer.
GeneRIF
Shen et al., Jiangyin, China. In Tumour Biol, 2012
PEBP4 over-expression may promote the invasion and metastasis of non-small cell lung cancer.
Expression of PEBP4 protein correlates with the invasion and metastasis of colorectal cancer.
GeneRIF
Jia et al., Beijing, China. In Tumour Biol, 2012
The over-expression of PEBP4 protein may be related to the tumorigenesis, development, metastasis, and invasion of colorectal cancer.
The expression of PEBP4 protein in lung squamous cell carcinoma.
GeneRIF
Ji et al., Jiangyin, China. In Tumour Biol, 2011
Data show that PEBP4 protein overexpression was associated with the occurrence, invasion, and metastasis of lung squamous cell carcinoma.
Regulation of human myoblast differentiation by PEBP4.
GeneRIF
Kolch et al., Glasgow, United Kingdom. In Embo Rep, 2009
Data show that PEBP4 participates in the control of muscle cell differentiation by modulating the activity of MEK and ERK.
[Signals and transcription factors].
Review
Ito, Kyoto, Japan. In Gan To Kagaku Ryoho, 1989
A repressor, PEBP4, has been identified which partly shares the recognition sequence with PEBP2.
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