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Platelet endothelial aggregation receptor 1

PEAR1, Jedi, Platelet endothelial aggregation receptor 1
PEAR1 is a platelet receptor that signals upon the formation of platelet-platelet contacts independent of platelet activation and secondary to platelet aggregation (Nanda et al., 2005 [PubMed 15851471]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: V1a, CAN, Akt, Src, HAD
Papers on PEAR1
GFP-specific CD8 T cells enable targeted cell depletion and visualization of T-cell interactions.
New
Impact
Brown et al., New York City, United States. In Nat Biotechnol, Dec 2015
The just EGFP death-inducing (Jedi) T cells enable visualization of a T-cell antigen.
Dextran sulfate triggers platelet aggregation via direct activation of PEAR1.
New
Hoylaerts et al., Leuven, Belgium. In Platelets, Dec 2015
We found that DxS elicited a concentration-dependent aggregation of human platelets resulting from direct PEAR1 activation by DxS.
Replication and hematological characterization of human platelet reactivity genetic associations in men from the Caerphilly Prospective Study (CaPS).
New
Johnson et al., Framingham, United States. In J Thromb Thrombolysis, Nov 2015
Previously, our group performed a genome-wide association study of platelet reactivity identifying single nucleotide polymorphisms (SNPs) associated with ADP- and epinephrine- induced aggregation, including SNPs in MRVI1, PIK3CG, JMJD1C, and PEAR1, among others.
Platelet endothelial aggregation receptor-1: a novel modifier of neoangiogenesis.
New
Verhamme et al., Leuven, Belgium. In Cardiovasc Res, Nov 2015
AIMS: Platelet endothelial aggregation receptor-1 (PEAR1) is a cell membrane protein, expressed on platelets and endothelial cells (ECs).
A Human Platelet Receptor Protein Microarray Identifies the High Affinity Immunoglobulin E Receptor Subunit α (FcεR1α) as an Activating Platelet Endothelium Aggregation Receptor 1 (PEAR1) Ligand.
New
Wright et al., Leuven, Belgium. In Mol Cell Proteomics, May 2015
Genome-wide association studies to identify loci responsible for platelet function and cardiovascular disease susceptibility have repeatedly identified polymorphisms linked to a gene encoding platelet endothelium aggregation receptor 1 (PEAR1), an "orphan" cell surface receptor that is activated to stabilize platelet aggregates.
Different models of inheritance in selected genes in patients with sticky platelet syndrome and fetal loss.
New
Danko et al., Bratislava, Slovakia. In Semin Thromb Hemost, Apr 2015
INTRODUCTION: The aim of this study was to evaluate the genetic variability of selected single nucleotide polymorphisms (SNPs) within GAS6 and PEAR1 genes and explore the association between selected SNPs and risk for fetal loss in women with sticky platelet syndrome (SPS).
PEAR1 is not a human hypertension-susceptibility gene.
New
Staessen et al., Leuven, Belgium. In Blood Press, Feb 2015
OBJECTIVE: Platelet endothelial aggregation receptor 1 (PEAR1) is a membrane protein involved in platelet contact-induced activation and sustained platelet aggregation.
Genetic Variation in the Platelet Endothelial Aggregation Receptor 1 Gene Results in Endothelial Dysfunction.
Lewis et al., Oklahoma City, United States. In Plos One, 2014
Platelet Endothelial Aggregation Receptor 1 (PEAR1) is a newly identified membrane protein reported to be involved in multiple vascular and thrombotic processes.
Genome-wide association study of platelet aggregation in African Americans.
Bray et al., Baltimore, United States. In Bmc Genet, 2014
Of these, three SNPs in three different loci were confirmed: 1) rs12041331, in PEAR1 (platelet endothelial aggregation receptor 1), replicated in both African and European Americans for collagen- and epinephrine-induced aggregation, and in European Americans for ADP-induced aggregation; 2) rs11202221, in BMPR1A (bone morphogenetic protein receptor type1A), replicated in African Americans for ADP-induced aggregation; and 3) rs6566765 replicated in European Americans for ADP-induced aggregation.
von Willebrand factor, Jedi knight of the bloodstream.
Review
Springer, Boston, United States. In Blood, 2014
Force and VWF function are so closely intertwined that, like members of the Jedi Order in the movie Star Wars who learn to use "the Force" to do good, VWF may be considered the Jedi knight of the bloodstream.
The adaptor protein GULP promotes Jedi-1-mediated phagocytosis through a clathrin-dependent mechanism.
Carter et al., Nashville, United States. In Mol Biol Cell, 2014
This clearance is mediated, in part, through the mammalian engulfment receptor Jedi-1.
Genetic determinants of on-aspirin platelet reactivity: focus on the influence of PEAR1.
Hvas et al., Århus, Denmark. In Plos One, 2013
RESULTS: The A-allele of the rs12041331 SNP in the platelet endothelial aggregation receptor-1 (PEAR1) gene was associated with reduced platelet aggregation and increased platelet activation, but not with cyclooxygenase-1 activity.
Genetic variants that affect platelet function.
Review
Nugent et al., Orange, United States. In Curr Opin Hematol, 2012
SUMMARY: Variation in MPV between normal individuals is responsible for roughly a two-fold range in platelet protein content, including key surface receptors and reactive granule constituents, the association of ADRA2, GP1BA, GP6, ITGA2 and P2Y12 variants with platelet reactivity, initially identified by candidate gene analyses, has now been validated by genome-wide approaches in much larger individual cohorts, and GWAS have identified novel gene variants, most notably PEAR1, that participate in variation in platelet reactivity among normal individuals, all of which contribute to a genetic basis for differences in platelet reactivty among normal individuals.
Identification of a specific intronic PEAR1 gene variant associated with greater platelet aggregability and protein expression.
GeneRIF
Becker et al., Baltimore, United States. In Blood, 2011
A specific intronic PEAR1 gene variant is ientified that associated with greater platelet aggregability and protein expression.
Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists.
Impact
Becker et al., Framingham, United States. In Nat Genet, 2010
PEAR1 (P=3.4x10(-12)),
Glial precursors clear sensory neuron corpses during development via Jedi-1, an engulfment receptor.
GeneRIF
Carter et al., Nashville, United States. In Nat Neurosci, 2009
a cellular and molecular mechanism by which neuronal corpses are culled during dorsal root ganglia development involves Jedi protein
A novel variant in the platelet endothelial aggregation receptor-1 gene is associated with increased platelet aggregability.
GeneRIF
Becker et al., Baltimore, United States. In Arterioscler Thromb Vasc Biol, 2008
C allele of PEAR1 (Platelet endothelial aggregation receptor-1)was generally associated in both ethnic groups with increased aggregation of native platelets
Jedi--a novel transmembrane protein expressed in early hematopoietic cells.
GeneRIF
Belyavsky et al., New York City, United States. In J Cell Biochem, 2007
Jedi is involved in the fine regulation of the early stages of hematopoietic differentiation, presumably through the Notch signaling pathway.
Novel targets for antithrombotic drug discovery.
Review
Phillips et al., San Francisco, United States. In Blood Cells Mol Dis, 2006
Nanda, P. Andre, M. Bao et al., Platelet aggregation induces platelet aggregate stability via SLAM family receptor signaling, Blood 106 (2005) 3028-3034, N. Nanda, M. Bao, H. Lin et al., Platelet Endothelial Aggregation Receptor 1 (PEAR1), a novel epidermal growth factor repeat-containing transmembrane receptor, participates in platelet contact-induced activation, J. Biol.
Platelet endothelial aggregation receptor 1 (PEAR1), a novel epidermal growth factor repeat-containing transmembrane receptor, participates in platelet contact-induced activation.
GeneRIF
Hart et al., Stanford, United States. In J Biol Chem, 2005
PEAR1 is a novel platelet receptor that signals secondary to alpha(IIb)beta(3)-mediated platelet-platelet contacts
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