β-Cell Insulin Secretion Requires the Ubiquitin Ligase COP1.
San Francisco, United States. In Cell, Jan 2016
Here, we show that post-translational regulation of the transcription factors ETV1, ETV4, and ETV5 by the ubiquitin ligase COP1 (also called RFWD2) in β cells is critical for insulin secretion.
Protein deregulation associated with breast cancer metastasis.
Belfast, United Kingdom. In Cytokine Growth Factor Rev, Aug 2015
This review will focus on a select group of proteins, often deregulated in breast cancer metastasis, which have shown therapeutic promise, notably, EMT, E-cadherin, Osteopontin, PEA3, Transforming Growth Factor Beta (TGF-β) and Ran.
ETS gene fusions in prostate cancer.
Male, Maldives. In Nat Rev Urol, 2009
Fusions involving ETV1, ETV4 and ETV5 occur less frequently but exhibit greater variability in fusion structure with 12 unique 5' fusion partners identified so far.