Prostacyclin receptors: Transcriptional regulation and novel signalling mechanisms.
Dublin, Ireland. In Prostaglandins Other Lipid Mediat, Sep 2015
Moreover, the functional implications of the interactions between the IP with PDZK1, a multi PDZ-domain containing protein essential for reverse-cholesterol transport and endothelialization, and the IP with IKEPP, the intestinal and kidney enriched PDZ protein, for the role of the prostacyclin-IP axis within the vasculature are reviewed.
HDL signaling and protection against coronary artery atherosclerosis in mice.
Hamilton, Canada. In J Biomed Res, Sep 2015
These signaling responses require the HDL receptor, scavenger receptor class B type 1 (SR-B1), an adaptor protein (PDZK1) that binds to the cytosolic C terminus of SR-B1, Akt1 activation and (at least in endothelial cells) activation of endothelial NO synthase (eNOS).